2 research outputs found
Towards Novel Treatments for Schizophrenia: Molecular and Behavioural Signatures of the Psychotropic Agent SEP-363856
Schizophrenia is a complex psychopathology whose treatment is still challenging. Given the limitations of existing antipsychotics, there is urgent need for novel drugs with fewer side effects. SEP-363856 (SEP-856) is a novel psychotropic agent currently under phase III clinical investigation for schizophrenia treatment. In this study, we investigated the ability of an acute oral SEP-856 administration to modulate the functional activity of specific brain regions at basal levels and under glutamatergic or dopaminergic-perturbed conditions in adult rats. We found that immediate-early genes (IEGs) expression was strongly upregulated in the prefrontal cortex and, to a less extent, in the ventral hippocampus, suggesting an activation of these regions. Furthermore, SEP-856 was effective in preventing the hyperactivity induced by an acute injection of phencyclidine (PCP), but not of d-amphetamine (AMPH). The compound effectively normalized the PCP-induced increase in IEGs expression in the PFC at all doses tested, whereas only the highest dose determined the major modulations on AMPH-induced changes. Lastly, SEP-856 acute administration corrected the cognitive deficits produced by subchronic PCP administration. Taken together, our data provide further insights on SEP-856, suggesting that modulation of the PFC may represent an important mechanism for the functional and behavioural activity of this novel compound
« Un roman de formation collectif ». Les revues féministes en Italie des années 1970 à nos jours
Depuis les années 1970, le mouvement féministe a conçu les revues non seulement comme un instrument d’expression et d’élaboration théorique, mais aussi comme un espace de militantisme, de remise en question des relations entre femmes et d’expérimentation de nouvelles pratiques politiques. Le format « revue » s’est ainsi transformé tant dans ses modalités de production et de diffusion que dans son rapport avec les lecteurs et les lectrices, et il constitue aujourd’hui, plus que tout autre matériau d’archive, un observatoire privilégié pour reparcourir les transformations du féminisme italien des trente dernières années du XXe siècle à nos jours. Ce dossier de Laboratoire italien, qui fait suite à un numéro consacré aux Voix et parcours du féminisme dans les revues de femmes (1870-1970), propose un premier état des lieux, sans prétention à l’exhaustivité, de la production éditoriale féministe protéiforme dans ses différentes phases et spécificités : du fort élan expérimental des années 1970, à l’intensification de la discussion théorique et de la production culturelle dans la décennie suivante, jusqu’au tournant numérique du nouveau millénaire et à la dimension transnationale des féminismes contemporains. Dagli anni Settanta del secolo scorso, il movimento femminista ha fatto delle riviste non solo uno strumento di espressione e di elaborazione teorica, ma uno spazio di militanza, di ripensamento delle relazioni tra donne e di sperimentazione di nuove pratiche politiche. La forma rivista ne è uscita quindi trasformata sia nelle sue modalità di produzione e diffusione sia nel rapporto con lettori e lettrici, e rappresenta oggi, più di qualsiasi altro materiale d’archivio, un osservatorio privilegiato per riattraversare le trasformazioni del femminismo italiano dagli ultimi trent’anni del Novecento alla contemporaneità . Questo fascicolo di «Laboratoire italien», che fa seguito a un numero dedicato a «Voci e percorsi del femminismo nelle riviste delle donne (1870-1970)», offre una prima ricognizione, senza pretese di esaustività , della multiforme produzione editoriale femminista nelle sue diverse fasi e nelle sue specificità : dalla forte spinta sperimentale degli anni Settanta, all’intensificarsi della discussione teorica e della produzione culturale nel decennio successivo, fino alla svolta multimediale del nuovo millennio e alla dimensione transnazionale dei femminismi contemporanei. Since the 1970s, the feminist movement has used magazines not only as a means of expression and theoretical production, but also as forums for activism, for evaluating relations between women and testing new political practices. Over the years, production and publishing methods have changed along with the relationship which the magazine has with readers. Nowadays, more than any other archive material, magazines function as a special observatory for tracing the transformations of Italian feminisms from the last thirty years of the 20th century to the present day. This issue of Laboratoire italien follows a previous one devoted to the Voices and Paths of Feminism in Women’s Magazines (1870-1970). It provides an initial appraisal—with no claim to be exhaustive—of the multifaceted editorial output of the Italian feminist movement through its different stages: from the experimental momentum of the 1970s to the intensification of theoretical discussion and cultural production in the following decade, and then on to the digital turn of the new millennium and the transnational dimension of contemporary feminisms