59 research outputs found
Anticancer activity of paclitaxel-loaded keratin nanoparticles in two-dimensional and perfused three-dimensional breast cancer models
Biomedical Applications of Reactive Oxygen Species Generation by Metal Nanoparticles
The design, synthesis and characterization of new nanomaterials represents one of the most dynamic and transversal aspects of nanotechnology applications in the biomedical field. New synthetic and engineering improvements allow the design of a wide range of biocompatible nanostructured materials (NSMs) and nanoparticles (NPs) which, with or without additional chemical and/or biomolecular surface modifications, are more frequently employed in applications for successful diagnostic, drug delivery and therapeutic procedures. Metal-based nanoparticles (MNPs) including metal NPs, metal oxide NPs, quantum dots (QDs) and magnetic NPs, thanks to their physical and chemical properties have gained much traction for their functional use in biomedicine. In this review it is highlighted how the generation of reactive oxygen species (ROS), which in many respects could be considered a negative aspect of the interaction of MNPs with biological matter, may be a surprising nanotechnology weapon. From the exchange of knowledge between branches such as materials science, nanotechnology, engineering, biochemistry and medicine, researchers and clinicians are setting and standardizing treatments by tuning ROS production to induce cancer or microbial cell death
Exploiting shock waves to trigger the anticancer sonodynamic activity of 5-Aminolevulinc acid-derived protoporphyrin IX on In Vitro 2D and 3D cancer models
Innovative formulations for the controlled and site-specific delivery of antiinflammatory drugs
Selective sensitiveness of mesenchymal stem cells to shock waves leads to anticancer effect in human cancer cell co-cultures
Squaraines bearing halogenated moieties as anticancer photosensitizers: Synthesis, characterization and biological evaluation
Sonodynamic treatment as an innovative bimodal anticancer approach: Shock wave-mediated tumor growth inhibition in a syngeneic breast cancer model
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