2,777 research outputs found
Non-Local Order Parameters as a Probe for Phase Transitions in the Extended Fermi-Hubbard Model
The Extended Fermi-Hubbard model is a rather studied Hamiltonian due to both
its many applications and a rich phase diagram. Here we prove that all the
phase transitions encoded in its one dimensional version are detectable via
non-local operators related to charge and spin fluctuations. The main advantage
in using them is that, in contrast to usual local operators, their asymptotic
average value is finite only in the appropriate gapped phases. This makes them
powerful and accurate probes to detect quantum phase transitions. Our results
indeed confirm that they are able to properly capture both the nature and the
location of the transitions. Relevantly, this happens also for conducting
phases with a spin gap, thus providing an order parameter for the
identification of superconducting and paired superfluid phasesComment: 7 pages, 3 figures; Submitted to EPJ Special Topics, Quantum Gases
and Quantum Coherenc
Focusing RF-on demand by logarithmic frequency-diverse arrays
The radiating systems exploiting the frequency diversity of the antennas are powerful architectures, that can have a big impact on wireless power transmission applications, but their characterization is merely theoretical. This paper offers a deep and critical numerical analysis of frequency- diverse arrays and shows the advantages of the family with logarithmic distribution of the frequency for radio-frequency energy focusing goals. For the first time, these systems are analyzed through a Harmonic Balance-based simulation combined with the full-wave description of the array made of eight planar monopoles: the rigorous results confirm the potentialities of these complex radiating systems, in particular show how the time-dependency of the radiating mechanism can be favorably deployed
Lipid-coated zinc oxide nanocrystals as innovative ROS-generators for photodynamic therapy
Photodynamic Therapy (PDT) is a medical treatment that combines the administration of a nontoxic drug, called photosensitizer (PS), with light irradiation of the targeted region. It has been proposed as a new cancer therapy, promising better selectivity and fewer side-effects compared to traditional chemo- and radio-therapies. PSs indeed can accumulate specifically within the region of interest so that when the light is directly focused only in that region the therapeutic effect is highly localized.
Traditional PSs, like chlorins and porphyrins, suffer from several drawbacks such as aggregation in biological media and poor biocompatibility. Thus, the development of innovative photosensitizers able to overcome these issues is crucial to the therapeutic action of PDT. Among the others, nanostructured Zinc Oxide (ZnO) has been recently proposed as new therapeutic agent and PS thanks to its semiconducting properties, biocompatible features, and ease of functionalization [1]. Nevertheless, further efforts are needed in order to improve its colloidal stability in biological media and to unravel the effective therapeutic mechanism.
Here, we propose the synthesis and characterization of lipid-coated ZnO nanoparticles as new photosensitizer for cancer PDT [2]. First, by Dynamic Light Scattering (DLS) experiments, we show that the lipid-coating increases the colloidal stability of the ZnO NPs in Phosphate buffered saline (PBS). Then, using Electron Paramagnetic Resonance (EPR) coupled with the spin-trapping technique, we demonstrate and characterize the ability of bare and lipid-coated ZnO NPs to generate Reactive Oxygen Species (ROS) in water only when remotely actuated via light irradiation. Interestingly, our results aware that the surface chemistry of the NPs greatly influence the type of photo-generated ROS. Finally, we show that our NPs are effectively internalized inside human epithelial carcinoma cells (HeLa) via a lysosomal pathway and that they are able to generate ROS inside cancer cells.
[1] B. Dumontel, M. Canta, H. Engelke, A. Chiodoni, L. Racca, A. Ancona, T. Limongi, G. Canavese and V. Cauda, ‎J. Mater. Chem. B. under revision.
[2] A. Ancona, H. Engelke, N. Garino, B. Dumontel, W.Fazzini and V. Cauda, to be submitted.
The support from ERC Starting Grant – Project N. 678151 “Trojananohorse” is gratefully acknowledged
SNOWFALL ANALYSIS OVER PENINSULAR ITALY IN RELATIONSHIP TO THE DIFFERENT TYPES OF SYNOPTIC CIRCULATION: FIRST RESULTS
The time series of snow data for a sample of Italian meteorological stations have been analyzed taking into account, for the time series, an acceptable continuity and quality of meteorological data. The data set is that of the Italian Meteorological Service (UGM), and refer to the period 1982–2004. The Slovenian station of Kredarica, located in the Julian Alps, has been added for convenience.
The study is composed of two different parts:
- Climatologic analysis of the snow parameters during the last 20 years. In particular, the height of the fresh snow and the number of days with permanence of snow at the ground have been analyzed.
- Evidence of the synoptic situations in which snowfalls are observed with at least a thickness of 10 cm in at least a third of the total number of analyzed stations in Central, Southern and insular Ital
Acoustic Emission from crumpling paper
From magnetic systems to the crust of the earth, many physical systems that
exibit a multiplicty of metastable states emit pulses with a broad power law
distribution in energy. Digital audio recordings reveal that paper being
crumpled, a system that can be easily held in hand, is such a system. Crumpling
paper both using the traditional hand method and a novel cylindrical geometry
uncovered a power law distribution of pulse energies spanning at least two
decades: (exponent 1.3 - 1.6) Crumpling initally flat sheets into a compact
ball (strong crumpling), we found little or no evidence that the energy
distribution varied systematically over time or the size of the sheet. When we
applied repetitive small deformations (weak crumpling) to sheets which had been
previously folded along a regular grid, we found no systematic dependence on
the grid spacing. Our results suggest that the pulse energy depends only weakly
on the size of the paper regions responsible for sound production.Comment: 12 pages of text, 9 figures, submitted to Phys. Rev. E, additional
information availible at http://www.msc.cornell.edu/~houle/crumpling
Gender Effect on Clinical Profiles, Pharmacological Treatments and Prognosis in Patients Hospitalized for Heart Failure
Heart failure (HF) is a significant disease affecting 1-2% of the general population. Despite its general aspects, HF, like other cardiovascular diseases, presents various gender-specific aspects in terms of etiology, hemodynamics, clinical characteristics, therapy, and outcomes. As is well known, HF with preserved ejection fraction more frequently affects females, with diabetes and arterial hypertension representing the most critical determinants of HF. On the other hand, women are traditionally underrepresented in clinical trials and are often considered undertreated. However, it is not clear whether such differences reflect cultural behaviors and clinical inertia or if they indicate different clinical profiles and the impact of sex on hard clinical outcomes. We aimed to review the sex-related differences in patients affected by HF
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