35 research outputs found
018 RELATIONSHIP OF WEIGHT CHANGE WITH CHANGE IN KNEE PAIN AND FUNCTION IN PERSONS WITH SYMPTOMATIC RADIOGRAPHIC KNEE OSTEOARTHRITIS: ONE-YEAR FOLLOW-UP DATA FROM THE OSTEOARTHRITIS INITIATIVE
Quality of life and radiographic severity of knee osteoarthritis predict total knee arthroplasty: data from the osteoarthritis initiative
Pro-Tumour Activity of Interleukin-22 in HPAFII Human Pancreatic Cancer Cells
Interleukin (IL)-22 is a cytokine involved in inflammatory and wound healing processes that is secreted primarily by T helper type 17 (Th17) cells. IL-22 receptor (IL-22R) expression is limited to epithelial cells of the digestive organs, respiratory tract and skin. Most tumours originating in these sites over-express IL-22R. Interestingly, there is an increase in Th17 frequency within the peripheral blood and tumour microenvironment of advanced cancer patients. Subsequently, IL-17 has been shown to display both pro-tumour and anti-tumour functions. Because many tumours lack expression of the IL-17 receptor, the effects of IL-17 on tumour growth are generated by cells that surround the tumour cells. Like IL-17, high levels of IL-22 have been detected in tumour tissues and the peripheral blood of cancer patients; however, the direct effect of IL-22 on tumour cells has remained largely unknown. In this report, we show that IL-22 stimulated production of vascular endothelial growth factor (VEGF) and the anti-apoptotic factor Bcl-X(L) in IL-22R-positive HPAFII human pancreatic cancer cells. Additionally, IL-22 augmented HPAFII cell production of immunosuppressive cytokines. We show further that IL-22 activation of HPAFII cells diminished T cell production of interferon (IFN)-γ through the action of IL-10. Strikingly, we show for the first time that IL-22 can fully protect cancer cells from natural killer (NK) cell-mediated cytotoxicity by stimulating tumour production of IL-10 and transforming growth factor (TGF)-β1. Our data support the idea that IL-22 may act to promote the pathogenesis of cancers rather than function in anti-tumour immunity
Use of the Anti-Inflammatory Cytokine Interleukin-11 to Reverse HIV-1gp120 Repression of a Natural Killer Cell Line
Enhancing natural killer (NK) cell activation has been associated with protection from human immunodeficiency virus-1 (HIV-1) infections and slowed onset of immunodeficiency. However, soluble HIV-1 envelope protein, gp120, has been shown to impair NK cell cytokine secretion and cell-mediated cytotoxicity. Here we show that gp120 suppressed IFN-γ production and cytotoxic function of a human NK cell line NK-92MI. We furthermore demonstrated that an anti-inflammatory cytokine interleukin-11 can restore effector functions to repressed NK-92MI cells. These studies support the notion that IL-11 administration may reduce HIV-1-mediated immune activation and exhaustion while achieving elimination of virally-infected cells through restored NK cell function
Weight loss is not associated with a reduction in the rate of decline in joint space width in subjects with symptomatic radiographic knee osteoarthritis: data from the osteoarthritis initiative
307 THE RELATIONSHIP OF WEIGHT CHANGE WITH CHANGES IN KNEE PAIN AND FUNCTION IN PERSONS WITH SYMPTOMATIC RADIOGRAPHIC KNEE OSTEOARTHRITIS: DATA FROM THE OSTEOARTHRITIS INITIATIVE
Features assessed on magnetic resonance images improve prediction of total knee arthroplasty in subjects with symptomatic radiographic knee osteoarthritis: data from the osteoarthritis initiative
018 RELATIONSHIP OF WEIGHT CHANGE WITH CHANGE IN KNEE PAIN AND FUNCTION IN PERSONS WITH SYMPTOMATIC RADIOGRAPHIC KNEE OSTEOARTHRITIS: ONE-YEAR FOLLOW-UP DATA FROM THE OSTEOARTHRITIS INITIATIVE
BRIDGING THE GAP BETWEEN NASA EARTH OBSERVATIONS AND DECISION MAKERS THROUGH THE NASA DEVELOP NATIONAL PROGRAM
The NASA DEVELOP National Program bridges the gap between NASA Earth Science and society by building capacity in both
participants and partner organizations that collaborate to conduct projects. These rapid feasibility projects highlight the capabilities
of satellite and aerial Earth observations. Immersion of decision and policy makers in these feasibility projects increases awareness
of the capabilities of Earth observations and contributes to the tools and resources available to support enhanced decision making.
This paper will present the DEVELOP model, best practices, and two case studies, the Colombia Ecological Forecasting project and
the Miami-Dade County Ecological Forecasting project, that showcase the successful adoption of tools and methods for decision
making. Through over 90 projects each year, DEVELOP is always striving for the innovative, practical, and beneficial use of NASA
Earth science data