26 research outputs found
Ethnopharmacological Approaches to Wound Repair
Wound is breaking of the skin by a physical injury. Wound
healing is a connective tissue response along with the repair
process which immediately comes after the injury. It occurs
as a sequence of phases such as haemostasis, inflammation,
proliferation, and remodelling and causes series of interactions
between the extracellular matrix, cytokine mediators,
and different cell types. For rapid healing several medicinal
plants were reported in ethnobotanical studies. Traditional
remedies which claimed to have wound healing potential are
widely used in developing countries due to their accessibility
and low cost. However, these remedies should be evaluated
for their efficacy and safety before their utilization. In this
context, the papers selected for this special issue include
scientifically evaluated information and lead to development
of novel drugs for rapid healing of wounds.We would like to
thank the authors for their contributions for this special issue.
This special issue contains twelve papers. T. Lin et al.
investigated the wound healing effect of tocopherol in diabetic
rats.This study has proven thewound healing potential
of tocopherol cream by increasing the rate of wound closure
and total protein content significantly in diabetic condition
Alpha amylase inhibitory activitv of some plant extracts with hyporrlycemic activity
Thirteen plant species which are claimed to have anti-diabetic activity (based on folk medicine and/or scientific reports) were tested for alpha amylase inhibitory activity. Two of the screened plants exhibited significant (more than 80%) alpha amylase inhibitory activity. lC50 of these plants was estimated based on the dried crude extract and found to be 0.08, and 0.2 mg/ml for Aloe vera and Paronychia argentea respectively. In A. vera the activity was most likely due to cinnamic acid derivatives. In P. argentea the activity was attributed to flavonoid components. These findings support the hypoglycemic activity of these species and give insight about the potential mechanism of their hypoglycemic activity
Platelet Aggregation Inhibitors from Aerial Parts of Grown in Jordan
From the aerial parts of Ruta chalepensis L., grown in Jordan, two furanocoumarins (bergapten and chalepensin), one flavonoid glycoside (rutin) as well as several minor compounds have been isolated. The structural elucidation of these compounds was established based on spectral data (UV, IR, MS, 1 H-NMR and 13 C-NMR). In Jordan, R. chalepensis is recommended for the treatment of rheumatism, mental disorders and menstrual problems. Fresh and dried leaves are used as flavoring agent in food and beverages. Antiplatelet activities of the crude methanolic and ethylacetate extracts in addition to the three isolated major compounds were measured by the aggrometric method according to Beretz and Casenave. Optical aggregometer connected to dual channel recorder was used for measuring aggregation. Both, ethylacetate and methanol extracts inhibited ADP- induced platelet aggregation (ADP-IA) of human blood. However, only ethylacetate extract was able to induce 50% inhibition of collagen-induced platelet aggregation (Co-IA) platelet rich plasma. Bergapten was more active against ADP-IA compared to chalepensin while the latter was more active against Co-IA compared to bergapten
Antioxidant and Antiproliferation Activities of Lemon Verbena (<i>Aloysia citrodora</i>): An In Vitro and In Vivo Study
Aloysia citrodora (Verbenaceae) is traditionally used to treat various diseases, including bronchitis, insomnia, anxiety, digestive, and heart problems. In this study, this plant’s antioxidant and anti-proliferation effects were evaluated. In addition to volatiles extraction, different solvent extracts were prepared. The GC-MS, LC-MS analysis and the Foline-Ciocalteu (F-C) method were used to investigate the phytochemical components of the plant. MTT assay was used to measure the antiproliferative ability for each extract. Antioxidant activity was determined using the 2,2-diphenylpicrylhydrazyl (DPPH) assay. In in vivo anti-proliferation experiments, Balb/C mice were inoculated with tumor cells and IP-injected with ethyl acetate extract of A. citrodora. After treatment, a significant reduction in tumor size (57.97%) and undetected tumors (44.44%) were obtained in treated mice, demonstrating the antiproliferative efficacy of the ethyl acetate extract. Besides, ethanol extract revealed the most potent radical scavenging effect. The findings of this study displayed that A. citrodora has promising cytotoxic and antioxidant activities. Still, further testing is required to investigate the extract’s chemical composition to understand its mechanisms of action
Antiobesity and antihyperglycaemic effects of Adiantum capillus-veneris extracts: in vitro and in vivo evaluations
Context: Adiantum capillus-veneris L. (Adiantaceae) hypocholesterolemic activity is therapeutically praised. Objectives: Pharmacological modulation of pancreatic triacylglycerol lipase (PL) and α-amylase/α-glucosidase by A. capillus-veneris are evaluated. Materials and methods: Using positive controls (acarbose, orlistat, guar gum, atorvastatin, glipizide and metformin) as appropriate, crude aqueous extracts (AEs) of A. capillus-veneris aerial parts were tested via a combination of in vitro enzymatic (0.24–100 mg/mL), acute in vivo carbohydrate tolerance tests (125, 250 or 500 mg/kg body weight [b.wt]) and chronic in vivo studies (500 mg/kg b.wt) in high cholesterol diet (HCD) fed Wistar rats. Results: Like acarbose, A. capillus-veneris as well as chlorogenic acid, with respective IC50 values (mg/mL) of 0.8 ± 0.0 and 0.2 ± 0.0, were identified as in vitro potent dual inhibitors of α-amylase/α-glucosidase. Unlike guar gum, A. capillus-veneris had no glucose diffusion hindrance capacity. Equivalent to orlistat, A. capillus-veneris and its phytoconstituents inhibited PL in vitro with an ascending order of PL- IC50 values (μg/mL): ferulic acid; 0.48 ± 0.06 < ellagic acid; 13.53 ± 1.83 < chlorogenic acid; 38.4 ± 2.8 < A. capillus-veneris; 1600 ± 100. Incomparable to acarbose or metformin and glipizide, A. capillus-veneris (125, 250 and 500 mg/kg b.wt) lacked antihyperglycaemic efficacies in acute starch- or glucose-evoked postprandial hyperglycaemia increments in normoglycaemic overnight fasting rats. Superior to atorvastatin; A. capillus-veneris exerted significant antiobesity (p < 0.001) with marked triacylglycerol-reducing capacities (p < 0.001) in comparison to rats fed with HCD for 10 weeks. Discussion and conclusion: A. capillus-veneris, modulating pancreatic digestive enzymes, may be advocated as a combinatorial diabesity prevention/phytotherapy agent