PENGARUH PEMBERIAN RAMUAN DAUN JATI BELANDA TERHADAP WANITA MENOPAUSE

Penyakit jantung dan pembuluh darah dapat disebabkan karena suatu kondisi yang disebut hiperkolesterolmia. Hiperkolesterolmia merupakan suatu kondisi dimana kadar kolesterol dalam darah lebih dari batas normal. Kadar kolesterol dalam darah dipengaruhi oleh asupan lemak. Penelitian ini bertujuan untuk mengetahui pengaruh pemberian ramuan daun jati belanda terhadap kadar kolesterol pada wanita menopause di Kelurahan Bandar Kidul Kota Kediri tahun 2022. Desain Penelitian yang digunakan adalah penelitian pre eksperimen dengan pendekatan One Group Pre Test Post Test Design.Populasi dalam penelitian ini adalah 16 wanita menopause dengan tehnik pengambilan sampel adalah Purposive sampling. Instrumen penelitian yang digunakan adalah alat tes darah Autocheck dan lembar observasi. Uji statistik yang digunakan adalah uji wilcoxon. Perubahan kadar kolesterol sebelum dan sesudah diberikan ramuan daun jati belanda yaitu terdapat selisih nilai sebesar 50,83 mg/dl. Pada Hasil uji statistic yaitu uji wilcoxon Kadar Kolesterol didapatkan p-value sebesar 0,000 maka nilai p-value kurang dari 0,05 (0,000 < 0,05). Hal ini menunjukkan bahwa H0 ditolak dan H1 diterima, artinya ada pengaruh pemberian ramuan daun jati belanda pada wanita menopause terhadap kadar kolesterol di Kelurahan Bandar Kidul Kota Kediri  tahun 2022. Berdasarkan dari hasil tersebut di atas, maka diharapkan wanita menopause dapat menggunakan pengobatan secara non farmakologi ramuan daun jati belanda untuk menurunkan kadar kolesterol.            Kata Kunci : Ramuan Daun Jati Belanda, Menopause, Kadar Kolestero

Ethnopharmacological Approaches to Wound Repair

Wound is breaking of the skin by a physical injury. Wound healing is a connective tissue response along with the repair process which immediately comes after the injury. It occurs as a sequence of phases such as haemostasis, inflammation, proliferation, and remodelling and causes series of interactions between the extracellular matrix, cytokine mediators, and different cell types. For rapid healing several medicinal plants were reported in ethnobotanical studies. Traditional remedies which claimed to have wound healing potential are widely used in developing countries due to their accessibility and low cost. However, these remedies should be evaluated for their efficacy and safety before their utilization. In this context, the papers selected for this special issue include scientifically evaluated information and lead to development of novel drugs for rapid healing of wounds.We would like to thank the authors for their contributions for this special issue. This special issue contains twelve papers. T. Lin et al. investigated the wound healing effect of tocopherol in diabetic rats.This study has proven thewound healing potential of tocopherol cream by increasing the rate of wound closure and total protein content significantly in diabetic condition

Antimicrobial resistance of Staphylococcus aureus, fecal streptococci, Enterobacteriaceae and Pseudomonas aeruginosa isolated from the coastal water of the Gaza strip-Palestine

Objectives: To document the occurrence and distribution of antibiotic resistance of clinically important bacteria in the seawater of Gaza strip-Palestine. Methods: Seawater samples were collected at 16 location distributed along the coast of the Gaza strip. Sampling was accomplished during 12 months, from March 2014 to June 2015. The microbial composition including Enterobacteriaceae, Staphylococcus aureus, fecal streptococci and Pseudomonas aeruginosa was recorded and tested for their resistance to specific antimicrobial agents according to CLSI using the disc diffusion method. Results: A total of 816 isolates of Enterobacteriaceae (377), S. aureus (29), fecal enterococci (FS)(369), and P. aeruginosa (29) were recovered and identified. Enterobacteriaceae, P. aeruginosa, FS and S. aureus isolates exhibited the highest rates of resistance against β-lactam drugs. The isolates also showed resistance to at least

Antimicrobial resistance of Staphylococcus aureus, fecal streptococci, Enterobacteriaceae and Pseudomonas aeruginosa isolated from the coastal water of the Gaza strip-Palestine

Objectives: To document the occurrence and distribution of antibiotic resistance of clinically important bacteria in the seawater of Gaza strip-Palestine. Methods: Seawater samples were collected at 16 location distributed along the coast of the Gaza strip. Sampling was accomplished during 12 months, from March 2014 to June 2015. The microbial composition including Enterobacteriaceae, Staphylococcus aureus, fecal streptococci and Pseudomonas aeruginosa was recorded and tested for their resistance to specific antimicrobial agents according to CLSI using the disc diffusion method. Results: A total of 816 isolates of Enterobacteriaceae (377), S. aureus (29), fecal enterococci (FS) (369), and P. aeruginosa (29) were recovered and identified. Enterobacteriaceae, P. aeruginosa, FS and S. aureus isolates exhibited the highest rates of resistance against β-lactam drugs. The isolates also showed resistance to at least one antimicrobial in the range between 99.7 to 78%. Multiple resistance occurred in almost 85% of all isolates; 99.2% of Enterobacteriaceae, 96.6% of P. aeruginosa, 72.1% of FS and 61% of S.aureus. The incidence of multiple resistance of isolates from all sampling locations ranged from 69.2 to 94.1%. Antibiotic resistance indices were found to be highest in P. aeruginosa (0.57), followed by E. coli (0.53), FS (0.49), Enterobacter (0.41), S. marcescens (0.40), Klebsiella (0.39) and&nbsp;finally Proteus (0.28). Most of the isolates showed multiple antibiotic resistance (MAR) index value higher than 0.2. Conclusions: This study demonstrated that the seawater of the Gaza strip is highly contaminated with antibiotic resistant bacteria which can be transmitted to humans through recreational and other activities. Therefore, there is a need to apply appropriate and rationale use of antibiotic to minimize the occurrence of multiple antibiotic resistant bacteria in the marine environment. Proper treatment of sewage before it is discharged to the sea is highly recommended.Keywords: Multiple antimicrobial resistance, Gaza strip, seawater, fecal enterococci, P. aeruginosa, Enterobacteriaceae, S. aureus

STRATEGI OPTIMALISASI POTENSI DAERAH DAN PENINGKATAN LITERASI SADAR GIZI PADA MASYARAKAT LEBOSARI MELALUI PROGRAM SEGANTING (OPTIMIZING REGIONAL POTENTIAL AND IMPROVING NUTRITIONAL LITERACY IN THE LEBOSARI COMMUNITY THROUGH THE SEGANTING PROGRAM)

Stunting merupakan kondisi di mana tinggi badan seseorang lebih rendah dibandingkan dengan mayoritas individu dalam kelompok usia yang sama disebabkan masalah gizi. Tingkat stunting yang cukup banyak di desa Lebosari mengindikasikan adanya tantangan signifikan terhadap kesadaran gizi dan potensi sumber daya daerah yang belum dimanfaatkan sepenuhnya. Dalam rangka mengatasi permasalahan ini, program SEGANTING diimplementasikan sebagai solusi yang dapat secara simultan meningkatkan pemahaman tentang gizi dan mengoptimalkan potensi desa. Program ini mencakup berbagai inisiatif termasuk inovasi pangan, Pojok gizi warga, dan bazar UMKM Desa Lebosari. Melalui tahapan Discovery, Dream, Design, serta Destiny yang melibatkan partisipasi aktif masyarakat, program SEGANTING dapat memberikan kontribusi pada peningkatan yang signifikan dalam pemahaman masyarakat Desa Lebosari tentang kesadaran gizi dalam mencegah stunting yang didukung oleh optimalisasi potensi yang ada di desa. Terbukti Sebelum program dimulai, hasil pre-test menunjukkan bahwa rata-rata persentase jawaban yang benar adalah 40,33. Namun, setelah program diimplementasikan, terjadi peningkatan sebanyak 54%, dengan rata-rata persentase jawaban yang benar mencapai 88,00 pada post-test

Chemical Profile of Cyperus laevigatus and Its Protective Effects against Thioacetamide-Induced Hepatorenal Toxicity in Rats

Cyperus species represent a group of cosmopolitan plants used in folk medicine to treat several diseases. In the current study, the phytochemical profile of Cyperus laevigatus ethanolic extract (CLEE) was assessed using UPLC-QTOF–MS/MS. The protective effect of CLEE at 50 and 100 mg /kg body weight (b.w.) was evaluated on hepatorenal injuries induced by thioacetamide (100 mg/kg) via investigation of the extract’s effects on oxidative stress, inflammatory markers and histopathological changes in the liver and kidney. UPLC-QTOF–MS/MS analysis of CLEE resulted in the identification of 94 compounds, including organic and phenolic acids, flavones, aurones, and fatty acids. CLEE improved the antioxidant status in the liver and kidney, as manifested by enhancement of reduced glutathione (GSH) and coenzyme Q10 (CoQ10), in addition to the reduction in malondialdehyde (MDA), nitric oxide (NO), and 8-hydroxy-2′-deoxyguanosine (8OHdG). Moreover, CLEE positively affected oxidative stress parameters in plasma and thwarted the depletion of hepatorenal ATP content by thioacetamide (TAA). Furthermore, treatment of rats with CLEE alleviated the significant increase in plasma liver enzymes, kidney function parameters, and inflammatory markers. The protective effect of CLEE was confirmed by a histopathological study of the liver and kidney. Our results proposed that CLEE may reduce TAA-hepatorenal toxicity via its antioxidant and anti-inflammatory properties suppressing oxidative stress

Pharmacological and Phytochemical Appraisal of Selected Medicinal Plants from Jordan with Claimed Antidiabetic Activities

Plant species have long been regarded as possessing the principal ingredients used in widely disseminated ethnomedical practices. Different surveys showed that medicinal plant species used by the inhabitants of Jordan for the traditional treatment of diabetes are inadequately screened for their therapeutic/preventive potential and phytochemical findings. In this review, traditional herbal medicine pursued indigenously with its methods of preparation and its active constituents are listed. Studies of random screening for selective antidiabetic bioactivity and plausible mechanisms of action of local species, domesticated greens, or wild plants are briefly discussed. Recommended future directives incurring the design and conduct of comprehensive trials are pointed out to validate the usefulness of these active plants or bioactive secondary metabolites either alone or in combination with existing conventional therapies