Chronobiological potential of human resources as a condition for ensuring socially safe activities in the development of the North

This paper presents an analysis of Russian scientific research in the field of the chronobiological potential of human resources as a condition for ensuring socially safe activities in the development of the North. The analysis of literary sources revealed that mainly works are devoted to characterization, including comparative, of individual physiological indicators. Most of the literature studied on the problems of human adaptation to the conditions of the north is devoted to the study of the functional state of the physiological systems of the indigenous and alien population to the harsh climatic conditions. Extreme north of the European, West Siberian, and less, East Siberian part of Russia. In connection with the development of natural resources, where there is no permanently resident population, such a non-traditional form of labor as a shift began to be used effectively. The time of the watch is determined by the conditions. Since newcomers will take part in the development of the Arctic latitudes, it is extremely important, from this point of view, information about seasonal exacerbations of functional systems of a pathological nature and disorders of the circadian chronorhythms of melatonin production resulting from changes in photoperiodism. In the analyzed works it is emphasized that the obtained information about the adaptation resources of various labor groups operating in the development of the Arctic latitudes, testifies not to the benefit of their health in comparison with the genetic potential of Aboriginal people. The results of the analysis of literary sources showed that the study of the potential of the human body from the point of view of determinism is not enough, since we can only register linear indicators. A look at this problem of the chronobiological potential of human resources from the point of view of fractal determinism is not well understood. © Published under licence by IOP Publishing Ltd

Development of Effervescent Granules with Solid Dispersion of Furazolidone

Introduction.In the treatment of infectious and inflammatory diseases, active substances (AI) are in demand, characterized by low resistance of microorganisms, high specificity of the mechanism of action and a wide spectrum of antimicrobial activity. Furazolidone (FZ) is an active substance that meets these criteria, but the fact that it is practically insoluble in water significantly limits its use. To increase the solubility and dissolution rate of active substances with low solubility in water, the method of solid dispersions (SD) allows. Previous studies indicate an increase in the solubility and dissolution rate of FZ in water from TD with polyvinylpyrrolidone-24000 (PVP-24000) in a ratio with AI > 6: 1 by weight. As a result, it becomes possible to introduce TD FZ into the composition of instant effervescent dosage forms, for example, Target. Development of the composition and technology for obtaining effervescent granules based on solid dispersions of FZ for obtaining a solution for external use. Materials and methods. FZ substance, polyvinylpyrrolidone-24000 ± 2000 (PVP-24000 ± 2000), tartaric acid, malic acid, anhydrous sodium carbonate, ethyl alcohol 96%, purified water. The granulates were obtained by fluidized bed granulation. The analysis of the obtained granules was carried out according to the following indicators: Description, granule size, weight loss upon drying, disintegration, dosing uniformity according to GPM.1.4.1.0004.15 "Granules". Also carried out a qualitative and quantitative determination of DI, analyzed the pH of an aqueous solution of granules. In order to study the stability and shelf life, the samples of granules were stored in accordance with OFS.1.10009.15 "Stability and shelf life of medicines".Results and discussion. The composition and technology of FZ effervescent granules for obtaining a solution for external use have been developed. The granules were obtained by separate granulation of the main (containing TD DV) and acidic components, followed by mixing in proportions that provide a solution of FZ with a concentration of 0.004% in water at room temperature. The quality of the resulting compositions was assessed, the shelf life (2 years) and storage conditions (in a dry place protected from light at a temperature of 25 °C) of the developed granule compositions were determined. Conclusion. As a result of technological and chemical-pharmaceutical studies using the TD method, a new dosage form of FZ has been developed - effervescent granules, which makes it possible to obtain an aqueous solution with an AI concentration of 0.004% in less than 5 minutes without heating. Based on the results of the work, an application was filed with Rospatent No. 2021105988 dated March 10, 2021 "Instantly soluble dosage form of furazolidone and a method for its preparation.". © Elagina A. O., Beliatskaya A. V., Krasnyuk (Jr.) I. I., Krasnyuk I. I., Stepanova O. I., Vorob'yov A. N., Fateeva T. V., 2022