167 research outputs found
Intellectuals in the fight for peace
https://stars.library.ucf.edu/prism/1486/thumbnail.jp
Nonengraftment Haploidentical Cellular Therapy for Hematologic Malignancies
Much of the therapeutic benefit of allogeneic transplant is by a graft versus tumor effect. Further data shows that transplant engraftment is not dependant on myeloablation, instead relying on quantitative competition between donor and host cells. In the clinical setting, engraftment by competition alone is not feasible due to the need for large numbers of infused cells. Instead, low-level host irradiation has proven to be an effective engraftment strategy that is stem cell toxic but not myeloablative. The above observations served as the foundation for clinical trials utilizing allogeneic matched and haploidentical peripheral blood stem cell infusions with minimal conditioning in patients with refractory malignancies. Although engraftment was transient or not apparent, there were compelling responses in a heavily pretreated patient population that appear to result from the breaking of tumor immune tolerance by the host through the actions of IFNγ, invariant NK T cells, CD8 T cells, NK cells, or antigen presenting cells
The MAJORANA DEMONSTRATOR: A Search for Neutrinoless Double-beta Decay of Germanium-76
The {\sc Majorana} collaboration is searching for neutrinoless double beta
decay using Ge, which has been shown to have a number of advantages in
terms of sensitivities and backgrounds. The observation of neutrinoless
double-beta decay would show that lepton number is violated and that neutrinos
are Majorana particles and would simultaneously provide information on neutrino
mass. Attaining sensitivities for neutrino masses in the inverted hierarchy
region, meV, will require large, tonne-scale detectors with extremely
low backgrounds, at the level of 1 count/t-y or lower in the region of
the signal. The {\sc Majorana} collaboration, with funding support from DOE
Office of Nuclear Physics and NSF Particle Astrophysics, is constructing the
{\sc Demonstrator}, an array consisting of 40 kg of p-type point-contact
high-purity germanium (HPGe) detectors, of which 30 kg will be enriched
to 87% in Ge. The {\sc Demonstrator} is being constructed in a clean
room laboratory facility at the 4850' level (4300 m.w.e.) of the Sanford
Underground Research Facility (SURF) in Lead, SD. It utilizes a compact graded
shield approach with the inner portion consisting of ultra-clean Cu that is
being electroformed and machined underground. The primary aim of the {\sc
Demonstrator} is to show the feasibility of a future tonne-scale measurement in
terms of backgrounds and scalability.Comment: Proceedings for the MEDEX 2013 Conferenc
Status of the MAJORANA DEMONSTRATOR experiment
The MAJORANA DEMONSTRATOR neutrinoless double beta-decay experiment is
currently under construction at the Sanford Underground Research Facility in
South Dakota, USA. An overview and status of the experiment are given.Comment: 8 pages, proceeding from VII International Conference on
Interconnections between Particle Physics and Cosmology (PPC 2013), submitted
to AIP proceeding
The MAJORANA DEMONSTRATOR: A Search for Neutrinoless Double-beta Decay of Germanium-76
The observation of neutrinoless double-beta decay would determine whether the
neutrino is a Majorana particle and provide information on the absolute scale
of neutrino mass. The MAJORANA Collaboration is constructing the DEMONSTRATOR,
an array of germanium detectors, to search for neutrinoless double-beta decay
of 76-Ge. The DEMONSTRATOR will contain 40 kg of germanium; up to 30 kg will be
enriched to 86% in 76-Ge. The DEMONSTRATOR will be deployed deep underground in
an ultra-low-background shielded environment. Operation of the DEMONSTRATOR
aims to determine whether a future tonne-scale germanium experiment can achieve
a background goal of one count per tonne-year in a 4-keV region of interest
around the 76-Ge neutrinoless double-beta decay Q-value of 2039 keV.Comment: Submitted to AIP Conference Proceedings, 19th Particles & Nuclei
International Conference (PANIC 2011), Massachusetts Institute of Technology,
Cambridge, MA, USA, July 24-29, 2011; 3 pages, 1 figur
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