Local quasiparticle density of states of superconducting SmFeAsO1−x1-xFxx single crystals: Evidence for spin-mediated pairing

We probe the local quasiparticles density-of-states in micron-sized SmFeAsO$_{1-x}$F$_{x}$ single-crystals by means of Scanning Tunnelling Spectroscopy. Spectral features resemble those of cuprates, particularly a dip-hump-like structure developed at energies larger than the gap that can be ascribed to the coupling of quasiparticles to a collective mode, quite likely a resonant spin mode. The energy of the collective mode revealed in our study decreases when the pairing strength increases. Our findings support spin-fluctuation-mediated pairing in pnictides.Comment: 11 pages, 4 figure

Distinguishing double neutron star from neutron star-black hole binary populations with gravitational wave observations

Gravitational waves from the merger of two neutron stars cannot be easily distinguished from those produced by a comparable-mass mixed binary in which one of the companions is a black hole. Low-mass black holes are interesting because they could form in the aftermath of the coalescence of two neutron stars, from the collapse of massive stars, from matter overdensities in the primordial Universe, or as the outcome of the interaction between neutron stars and dark matter. Gravitational waves carry the imprint of the internal composition of neutron stars via the so-called tidal deformability parameter, which depends on the stellar equation of state and is equal to zero for black holes. We present a new data analysis strategy powered by Bayesian inference and machine learning to identify mixed binaries, hence low-mass black holes, using the distribution of the tidal deformability parameter inferred from gravitational-wave observations.Comment: 13 pages, 6 figures - v2: matches the published version in Phys. Rev. D 102, 02302

Current pharmacological treatment of idiopathic inflammatory myopathies

The idiopathic inflammatory myopathies are uncommon and heterogeneous disorders. Their classification is based on distinct clinicopathologic features. Although idiopathic inflammatory myopathies share some similarities, different subtypes may have variable responses to therapy, so it is very important to distinguish the correct subtype. There are few randomised, double blind placebo controlled studies to support the current treatment. High dose corticosteroids continue to be the first-line therapy and other immunosupressive drugs are used in refractory cases, as well as steroid-sparing agents. Some novel therapeutic approaches have emerged as potential treatment including tacrolimus, intravenous immunoglobulin and rituximab, following good outcomes reported in case studies. However, more randomised controlled trials are needed. This review considers the current and the potential future therapies for inflammatory myopathies

Polaronic signature in the metallic phase of La0.7Ca0.3MnO3 films detected by scanning tunneling spectroscopy

In this work we map tunnel conductance curves with nanometric spatial resolution, tracking polaronic quasiparticle excitations when cooling across the insulator-to-metal transition in La0.7Ca0.3MnO3 films. In the insulating phase the spectral signature of polarons, a depletion of conductance at low bias flanked by peaks, is detected all over the scanned surface. These features are still observed at the transition and persist on cooling into the metallic phase. Polaron-binding energy maps reveal that polarons are not confined to regions embedded in a highly-conducting matrix but are present over the whole field of view both above and below the transition temperature.Comment: 10 pages, 4 figure

The M(BH)-Sigma Relation for Supermassive Black Holes

We investigate the differences in the M(BH)-sigma relation derived recently by Ferrarese & Merritt (2000) and Gebhardt et al. (2000). The shallower slope found by the latter authors (3.75 vs. 4.8) is due partly to the use of a regression algorithm that ignores measurement errors, and partly to the value of the velocity dispersion adopted for a single galaxy, the Milky Way. A steeper relation is shown to provide a better fit to black hole masses derived from reverberation mapping studies. Combining the stellar dynamical, gas dynamical, and reverberation mapping mass estimates, we derive a best-fit relation M(BH) = 1.30 (+/- 0.36) X 10^8 (sigma_c/200)^{4.72(+/- 0.36)}, where M(BH) is in solar masses, and sigma in km/s.Comment: The Astrophysical Journal, in pres

Looking at COVID-19 from a Systems Biology Perspective

The sudden outbreak and worldwide spread of the SARS-CoV-2 pandemic pushed the scientific community to find fast solutions to cope with the health emergency. COVID-19 complexity, in terms of clinical outcomes, severity, and response to therapy suggested the use of multifactorial strategies, characteristic of the network medicine, to approach the study of the pathobiology. Proteomics and interactomics especially allow to generate datasets that, reduced and represented in the forms of networks, can be analyzed with the tools of systems biology to unveil specific pathways central to virus\u2013human host interaction. Moreover, artificial intelligence tools can be implemented for the identification of druggable targets and drug repurposing. In this review article, we provide an overview of the results obtained so far, from a systems biology perspective, in the understanding of COVID-19 pathobiology and virus\u2013host interactions, and in the development of disease classifiers and tools for drug repurposing

Differential cross section analysis in kaon photoproduction using associated legendre polynomials

Angular distributions of differential cross sections from the latest CLAS data sets \cite{bradford}, for the reaction ${\gamma}+p {\to} K^{+} + {\Lambda}$ have been analyzed using associated Legendre polynomials. This analysis is based upon theoretical calculations in Ref. \cite{fasano} where all sixteen observables in kaon photoproduction can be classified into four Legendre classes. Each observable can be described by an expansion of associated Legendre polynomial functions. One of the questions to be addressed is how many associated Legendre polynomials are required to describe the data. In this preliminary analysis, we used data models with different numbers of associated Legendre polynomials. We then compared these models by calculating posterior probabilities of the models. We found that the CLAS data set needs no more than four associated Legendre polynomials to describe the differential cross section data. In addition, we also show the extracted coefficients of the best model.Comment: Talk given at APFB08, Depok, Indonesia, August, 19-23, 200

Ligand-Based Regulation of Dynamics and Reactivity of Hemoproteins

Hemoproteins include several heme-binding proteins with distinct structure and function. The presence of the heme group confers specific reactivity and spectroscopic properties to hemoproteins. In this review, we provide an overview of five families of hemoproteins in terms of dynamics and reactivity. First, we describe how ligands modulate cooperativity and reactivity in globins, such as myoglobin and hemoglobin. Second, we move on to another family of hemoproteins devoted to electron transport, such as cytochromes. Later, we consider heme-based reactivity in hemopexin, the main heme-scavenging protein. Then, we focus on heme-albumin, a chronosteric hemoprotein with peculiar spectroscopic and enzymatic properties. Eventually, we analyze the reactivity and dynamics of the most recently discovered family of hemoproteins, i.e., nitrobindins