438 research outputs found
In Vivo Survival and Homeostatic Proliferation of Natural Killer Cells
While the specificity and development of natural killer (NK) cells have been intensely studied, little is known about homeostasis of the mature NK population. Here we show that mouse NK cells undergo homeostatic proliferation when transferred into NK-deficient Rag−/− γC−/− hosts. Normal NK functional activity is maintained during this process, although there are some changes in NK phenotype. Using cell sorting, we demonstrate that mature (Mac-1hi) NK cells undergo homeostatic proliferation in an NK-deficient environment, yet immature (Mac-1lo) NK cells also proliferate in such hosts. We find that mature NK cells survive but do not proliferate in hosts which possess an endogenous NK pool. However, we go on to show that mature NK survival is critically dependent on interleukin (IL)-15. Surprisingly, NK survival is also compromised after transfer of cells into IL-15Rα−/− mice, implying that IL-15 responsiveness by bystander cells is critical for NK maintenance. These data imply that, similar to T cells, homeostasis of the NK pool is much more dynamic than previously appreciated and this may be relevant to manipulation of NK cells for therapeutic purposes
Wide-angle elastic scattering and color randomization
Baryon-baryon elastic scattering is considered in the independent scattering
(Landshoff) mechanism. It is suggested that for scattering at moderate
energies, direct and interchange quark channels contribute with equal color
coefficients because the quark color is randomized by soft gluon exchange
during the hadronization stage. With this assumption, it is shown that the
ratio of cross sections at CM angle
decreases from a high energy value of R_{\pbar p / pp} \approx 1/2.7, down to
R_{\pbar p / pp} \approx 1/28, compatible with experimental data at moderate
energies. This sizable fall in the ratio seems to be characteristic of the
Landshoff mechanism, in which changes at the quark level have a strong effect
precisely because the hadronic process occurs via multiple quark scatterings.
The effect of color randomization on the angular distribution of proton-proton
elastic scattering and the cross section ratio is also discussed.Comment: 18 pages, latex2e, 4 uuencoded figures, include
Two spatial scales in a bleaching event : corals from the mildest and the most extreme thermal environments escape mortality
Author Posting. © Association for the Sciences of Limnology and Oceanography, 2013. This article is posted here by permission of Association for the Sciences of Limnology and Oceanography for personal use, not for redistribution. The definitive version was published in Limnology and Oceanography 58 (2013): 1531-1545, doi:10.4319/lo.2013.58.5.1531.In summer 2010, a bleaching event decimated the abundant reef flat coral Stylophora pistillata in some areas of the central Red Sea, where a series of coral reefs 100–300 m wide by several kilometers long extends from the coastline to about 20 km offshore. Mortality of corals along the exposed and protected sides of inner (inshore) and mid and outer (offshore) reefs and in situ and satellite sea surface temperatures (SSTs) revealed that the variability in the mortality event corresponded to two spatial scales of temperature variability: 300 m across the reef flat and 20 km across a series of reefs. However, the relationship between coral mortality and habitat thermal severity was opposite at the two scales. SSTs in summer 2010 were similar or increased modestly (0.5°C) in the outer and mid reefs relative to 2009. In the inner reef, 2010 temperatures were 1.4°C above the 2009 seasonal maximum for several weeks. We detected little or no coral mortality in mid and outer reefs. In the inner reef, mortality depended on exposure. Within the inner reef, mortality was modest on the protected (shoreward) side, the most severe thermal environment, with highest overall mean and maximum temperatures. In contrast, acute mortality was observed in the exposed (seaward) side, where temperature fluctuations and upper water temperature values were relatively less extreme. Refuges to thermally induced coral bleaching may include sites where extreme, high-frequency thermal variability may select for coral holobionts preadapted to, and physiologically condition corals to withstand, regional increases in water temperature.J.C.B.S. was partially supported by Fundac¸a˜o para a Cieˆncia e
a Tecnologia (project PEst-C/MAR/LA0015/2011) and by the
European Regional Development Fund through the Operational
Competitiveness Programme (National Strategic Reference
Framework). Kristen Davis was partially supported by a Woods
Hole Oceanographic Institution postdoctoral scholarship. This research was supported by KAUST with awards USA 00002 and
KSA 00011
Diagnosing Spin at the LHC via Vector Boson Fusion
We propose a new technique for determining the spin of new massive particles
that might be discovered at the Large Hadron Collider. The method relies on
pair-production of the new particles in a kinematic regime where the vector
boson fusion production mechanism is enhanced. For this regime, we show that
the distribution of the leading jets as a function of their relative azimuthal
angle can be used to distinguish spin-0 from spin-1/2 particles. We illustrate
this effect by considering the particular cases of (i) strongly-interacting,
stable particles and (ii) supersymmetric particles carrying color charge. We
argue that this method should be applicable in a wide range of new physics
scenarios.Comment: 5 pages, 4 figure
Sphaleron Effects Near the Critical Temperature
We discuss one-loop radiative corrections to the sphaleron-induced baryon
number-violating transition rate near the electroweak phase transition in the
standard model. We emphasize that in the case of a first-order transition a
rearrangement of the loop expansion is required close to the transition
temperature. The corresponding expansion parameter, the effective 3-dimensional
gauge coupling approaches a finite dependent value at the critical
temperature.
The
(Higgs mass) dependence of the 1-loop radiative corrections is discussed in
the framework of the heat kernel method. Radiative corrections are small
compared to the leading sphaleron contribution as long as the Higgs mass is
small compared to the W mass. To 1-loop accuracy, there is no Higgs mass range
compatible with experimental limits where washing-out of a B+L asymmetry could
be avoided for the minimal standard model with one Higgs doublet.Comment: 17 pages, RevTeX, (4 figures in a separate uuencoded file),
HD-THEP-93-23re
Nearby quasar remnants and ultra-high energy cosmic rays
As recently suggested, nearby quasar remnants are plausible sites of
black-hole based compact dynamos that could be capable of accelerating
ultra-high energy cosmic rays (UHECRs). In such a model, UHECRs would originate
at the nuclei of nearby dead quasars, those in which the putative underlying
supermassive black holes are suitably spun-up. Based on galactic optical
luminosity, morphological type, and redshift, we have compiled a small sample
of nearby objects selected to be highly luminous, bulge-dominated galaxies,
likely quasar remnants. The sky coordinates of these galaxies were then
correlated with the arrival directions of cosmic rays detected at energies EeV. An apparently significant correlation appears in our data. This
correlation appears at closer angular scales than those expected when taking
into account the deflection caused by typically assumed IGM or galactic
magnetic fields over a charged particle trajectory. Possible scenarios
producing this effect are discussed, as is the astrophysics of the quasar
remnant candidates. We suggest that quasar remnants be also taken into account
in the forthcoming detailed search for correlations using data from the Auger
Observatory.Comment: 2 figures, 4 tables, 11 pages. Final version to appear in Physical
Review
Baryogenesis, Electric Dipole Moments and Dark Matter in the MSSM
We study the implications for electroweak baryogenesis (EWB) within the
minimal supersymmetric Standard Model (MSSM) of present and future searches for
the permanent electric dipole moment (EDM) of the electron, for neutralino dark
matter, and for supersymmetric particles at high energy colliders. We show that
there exist regions of the MSSM parameter space that are consistent with both
present two-loop EDM limits and the relic density and that allow for successful
EWB through resonant chargino and neutralino processes at the electroweak phase
transition. We also show that under certain conditions the lightest neutralino
may be simultaneously responsible for both the baryon asymmetry and relic
density. We give present constraints on chargino/neutralino-induced EWB implied
by the flux of energetic neutrinos from the Sun, the prospective constraints
from future neutrino telescopes and ton-sized direct detection experiments, and
the possible signatures at the Large Hadron Collider and International Linear
Collider.Comment: 32 pages, 10 figures; version to appear on JHE
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