Fred Farr Is Our Friend, Campaign Poster

Poster promoting Fred Farr\u27s campaign for California State Assembly. Features a headshot of Farr in a button-up shirt, with his necktie over his shoulder. Poster text: Fred Farr is our friend. Return him to Sacramento June 17th. Fred Farr has the experience. Fred Farr can be effective.https://digitalcommons.csumb.edu/fredfarr_campaign/1003/thumbnail.jp

Fred Farr State Assembly Campaign Flyer

Flyer for Fred Farr\u27s California State Assembly campaign. Features an image of Farr on the front, along with campaign message: On Tuesday November 2nd elect Fred Farr, lawyer-democrat, for all of the people of Monterey County, as our next State Assemblyman. On the back is an image of Farr sitting with his family in their living room. Fred is seated on a couch with his wife and two daughters, and his son, Sam Farr, is in a chair, with the family dog on his lap. Photo caption: Sam 13, Oofie (ageless), Janet Farr, Fred Farr, Nancy 6, Francesca 12. Also on back: As a parent and PTA member Fred Farr has a big stake in the future of Monterey County. Remember in Nov.--Let\u27s go Farr for all of the People.https://digitalcommons.csumb.edu/fredfarr_campaign/1001/thumbnail.jp

Changing characteristics of hospital admissions but not the children admitted—a whole population study between 2000 and 2013

Funding: The data were hosted in the safe haven thanks to funding by the FARR institution. Open Access via Springer Compact Agreement.Peer reviewedPublisher PD

Comparison and evaluation of different methodologies and tests for detection of anti-dsDNA antibodies on 889 Slovenian patients’ and blood donors’ sera

Aim To evaluate four different commercially available assays for anti-double stranded DNA (dsDNA) detection and compare them with the in-house radioimmunoassay according to Farr (FARR-RIA) in order to select the optimal primary method for use in combination with FARR-RIA. Methods Sera from 583 consecutive patients sent to our laboratory for routine diagnosis, 156 selected patients with autoimmune diseases (76 systemic lupus erythematosus [SLE] patients and 80 patients with other autoimmune diseases), and 150 blood donors were tested for anti-dsDNA antibodies with two enzyme-linked immunoassays (ELISA), two Crithidia luciliae immunoflourescence tests (CLIFT), and FARR-RIA. The specificities and sensitivities of the tests were calculated and compared. Results FARR-RIA and CLIFT 2 showed the highest specificity for SLE (100%), with CLIFT 2 showing higher sensitivity (33% vs 47%). Both ELISAs showed higher sensitivities (>53%) than FARR-RIA but lower specificities (<93%), whereas CLIFT 1 showed the lowest overall agreement with FARR-RIA. Conclusion CLIFT 2 was selected as the primary test for use in combination with FARR-RIA. The use of CLIFT 2 reduced the number of sera that needed to be tested by FARR-RIA, the time needed to report the results, and environmental toxicity, cancerogenicity, and radioactivity

Fred Farr Scrapbook, 1965 Clippings, Legislative Session & Year

Majority of clippings pertain to Farr\u27s legislative efforts throughout 1965, particularly in the areas of environmental conservation and highway beautification. Farr\u27s bill mandating that growers provide toilets and washing facilities for field workers, investigations into incidents involving the Hell\u27s Angels Motorcycle Club, and Farr\u27s work with the Senate Interim Committee on Natural Resources are also represented. An article on Farr\u27s son, future congressman Sam Farr, highlighting his work as a Peace Corps volunteer in Colombia, is included on page 8. Clippings date from January 1, 1965, to December 2, 1965.https://digitalcommons.csumb.edu/fredfarr_scrapbooks/1004/thumbnail.jp

Fredrick S. Farr for Carmel City Council

Flyer promoting Fred Farr\u27s campaign for Carmel City Council. Features black and white headshot of Farr. Flyer text: Fredrick S. Farr for Carmel City Council, Election Tuesday, April 11, 1950.https://digitalcommons.csumb.edu/fredfarr_campaign/1005/thumbnail.jp

Identification and characterization of farR and farE as a regulator and effector of fatty acid resistance in Staphylococcus aureus

Although Staphylococcus aureus is exposed to antimicrobial fatty acids on the skin, in nasal secretions and in abscesses, specific mechanisms for regulating gene expression and intrinsic resistance in response to these fatty acids have not been reported. Through in vitro selection for increased resistance of S. aureus to linoleic acid, I identified fatty acid resistant clone FAR7, where a single nucleotide polymorphism caused a His121Tyr substitution in an uncharacterized member of the TetR family of transcriptional regulators, which is divergently transcribed from a gene encoding a member of the resistance-nodulation-division superfamily of multi-drug efflux pumps. I named these genes farE and farR, for regulator and effector of fatty acid resistance, respectively. S. aureusDfarER exhibited loss of inducible resistance to linoleic acid, and although FarR is a TetR family regulator which typically repress expression of a divergent gene, I found that FarR is needed to induce farE. Compared to wild type S. aureus, FAR7 exhibited increased expression of farR and farE under non-inducing conditions, and a significantly higher induced level of farE. Electrophoretic mobility shift assays revealed a FarR binding site in the farER intergenic segment, that overlaps with the +1 transcription start site of farR as determined by 5\u27-RACE. The variant FarR7 produced by S. aureus FAR7 failed to bind to this operator site, and nucleotide substitutions within the operator abolished binding of native FarR. Conversely, FarR and FarR7 bound equally well to a second operator site upstream of the predicted farE promoter. Therefore, like other TetR regulators, FarR represses its own expression, and a His121Tyr substitution in FarR causes a loss of auto-repression and increases expression of both farR and farE. My data reports the first description of a specific mechanism of inducible resistance to antimicrobial fatty acids in a Gram-positive pathogen and defines a new paradigm for regulation of a divergently transcribed gene by a TetR family regulator

Fred Farr State Senate Campaign Postcard

Postcard in support of Fred Farr\u27s re-election to the California State Senate. Features a message about the primary election, a portrait photo of Farr, and a small sketch of the top of the California State Capitol building. Postcard text: Dear Friend, Our State Senator, Fred Farr, is running for re-election at the June 5th Primary. In my opinion he has served Monterey County capably, effectively, and faithfully. Therefore I believe he should be retained to represent us in Sacramento. Won\u27t you join with me in voting, and ask your friend to vote for Senator Farr\u27s re-election on Tuesday, June 5th?https://digitalcommons.csumb.edu/fredfarr_campaign/1000/thumbnail.jp