Pimecrolimus cream in repigmentation of vitiligo

Background: Vitiligo is a chronic disease that mostly affects children and young adults. Nowadays many treatment options are available; however, most of them have limited efficacy and in most cases would result in undesirable complications. Objective: To determine the extent of repigmentation according to the location of the lesions after applying topical cream pimecrolimus 1 in vitiligo patients. Materials and Methods: Thirty consecutive patients with vitiligo lesions affecting less than 20 of body surface area without any previous history of spontaneous repigmentation were treated with pimecrolimus cream 1 twice daily for 12 weeks. The extent of repigmentation in vitiligo lesions was determined in each patient after 6 and 12 weeks. Results: Moderate to excellent response (repigmentation >26) was observed in 6.6 and 25.9 of vitiligo lesions 6 and 12 weeks after treatment, respectively. More responsive lesions were located on the trunk, face and elbow (85.7, 75 and 70). Conclusion: Pimecrolimus cream 1 results in repigmentation in vitiligo in different extents according to the location of the lesion; however, to clearly prove its efficacy as monotherapy or in combination with other available treatment options, double-blind placebo-controlled studies are essential. Copyright © 2007 S. Karger AG

Report of two cases of tuberculos Gumma

Tuberculos Gumma is one of the various clinical manifestations of cutaneous TB that is characterized by non tender, undolent subcutaneous nodules which progressively involve the skin and take the appearance of an ulcer. In this article, we present two young patients, affected with tuberculos gumma. One of them, presented with multiple abcesses on the face and extremities, associated with pulmonary involvement and arthritis of the left wrist. The other one had just one subcutaneous nodule on the face, with positive familial history of pulmonary TB and tuberculos lymphadenitis in her two brothers. Both patients were cured with anti TB treatment

One year survey of hospitalized psoriatic patients and their treatment in Razi Hospital

During one year survey, 77 psoriatic patients were hospitalized in the dermatology department of Razi Hospital. This comprised 19% of admitted patients in this period. 29% (n=22) of psoriatic patients had previous history of hospitalization. On admission, the mean age of patients was 32.8 years, the mean and peak age of disease onset were 26.46 and between 11-20 years, respectively. 14% (n=10) of the patients had a family history of psoriasis and 70% (n=7) of those with a positive family history had their age of onset under 20 years. Involvement of different regions was as follows: Scalp: 88% (n=68), nails: 53% (n=41) and joints (arthritis): 10% (n=8). Psoriasis was associated with scrotal tongue in 19% (n=13) and with geographic tongue in 10% (n=8) of patients. Regarding the medical treatment, the drugs which were used most frequently were tigason in 34% (n=41) and ditranol in 22% (n=26) of the cases. The mean duration of hospitalization was 39.29 days and most patients were discharged from the hospital in a good condition without any serious complication. During this period 9% of patients had a relapse of their disease

The Study of Etiologic Causes of Dermatophyte in the Location of Foot And Groin, and the Possibility of Association of Dermatophytoses of These Two Locations Together

Superficial mycosis of the skin is one of the most prevalent human infections. Within these infections, tinea pedis and tinea cruris have been studied. Different aetiologic causes play role in these infections which the most important of them are Trichophyton rubrum, Trichophyton Mentagrophyte and Epidermophyton floccosum. Prevalence arrangement of these causes are defferent in societies. This study is a case series study which in the course of this period 42 affected patients 0 tinea pedis and 40 affected patients to tinea cruris have been studied. From patients with doubtfull clinical lesion, whom have reffered to Razi Hospital within the first six months of the year 77, smear and culture were provided and in the meanwhile for consideration of possible association of Dermatophytoses in these two location in cases of clinical doubt to tinea pedis among the affected patients to tinea cruris, smear and culture wase made and it wase observed that 40 of affected patients to tinea cruris, 4 patients simultaneously have tinea pedis (10%). In this study also, risk factors of tinea pedis and tinea cruris have been studied. Etiologic causes in tinea pedis in this study with respect to arrangment are: T.Ment, T.rubrum and then Epid.floccosum and the causes of thinea cruris with respect to arrangment are: Epid.floccosum, T.rubrum and then T.Ment. In this study foot and groin Etiologic factors have been considered, it was observed that the pattern of their etiologic causes in Iran with respect to other countries are different

Three familial cases of Pasini variant of dominant dystrophic epidermolysis

Epidermolysis bullosa (EB) is the term applied to a group of disorders whose common primary feature is the formation of blisters following trivial trauma. Hereditary EB comprises 3 major classes: simplex, junctional and dystrophic, and includes more than 23 phenotypes. The albopapuloid pasini variant of dominant dystrophic EB is characterized by a distinctive clinical appearance. In this article, we report this disease in three members of a family (father and two sons)

Alopecia-Areata Like Alopecia in Mycosis Fungoides, a Case Report

Mycosis Fungoides (MF) is a cutaneous T-cell lymphoma (2,5). Alopecia is rarely seen in this disease, and the reported cases are in the form of follicular mucinosis (1,2,4). In this case report a patient is presented whose lesions all showed alopecia without mucinosis. Furthermore there was a patch of alopecia without any epidermal changes, which was clinicaly identical with alopecia areata, and histologically identical with MF. After six months of treatment there is regrowth of almost normal hair on all of the lesion

CLINICAL AND PATHOLOGICAL CHARACTERISTICS OF BASAL CELL CARCINOMA ARISING FROM CHRONIC RADIATION DERMATITIS

Clinical and histopathological features of basal cell carcinoma (BCC) may differ according to the type of carcinogen involved. BCC arising from radiotherapy treatment has high incidence and its clinical and histopathological features may be different from BCCs caused by other carcinogens. The aim of our study was to investigate any possible association between specific histopathological or clinical features and chronic radiation dermatitis as the cause of BCC. In this study, 87 patients with previous history of radiotherapy on the site of BCC (exposed) were selected as group A and matched with 87 other patients with BCC without such a history as group B (unexposed). The two groups were compared based on certain clinical features such as size, number and location of the tumors and also based on the histopathological features. In the exposed group, the most frequent histopathological type was pigmented solid type (73.5%), while in the unexposed group solid type (66.7%) was the most frequent feature. Multiple tumors were found in 86.2% of the exposed patients, while just 12.6% of the unexposed patients had multiple tumors. In the unexposed group, the face was the most frequent location (94.3%) and the mean size was 1 cm in diameter, while in the exposed group the most frequent location was the scalp and the mean size was 0.5 cm. BCCs arising on a background of radiation dermatitis are usually of pigmented solid type, multiple, smaller in size and normally are seen on the areas exposed to X-ray therapy

The frequency of Tinea Pedis in patients with Tinea Cruris

The frequency of tinea pedis in patients with tinea cruris has not been elucidated. The main objective of this study is to define this frequency all patients referred to the Mycological Laboratory of Razi Hospital, Tehran, during a 3-month period in 1997, who had a positive KOH smear for dermatophyte in the groin area were included in the study. A culture from this site, and a smear and culture from the foot (regardless of the presence of any lesion), were performed. Sixty patients (46 males and 14 females) entered the study .Epidermophyton floccosum was the most frequent isolated fungus in tinea cruris. Four patients (6.4%) had concurrent tinea pedis proved by smear and culture; and the sole isolate form the foot, was Trichophyton mentagrophtes. In three of them, the corresponding dermatophyte in the groin was E. floccosum. In this study, the frequency of tinea pedis in patients with tinea cruris was lo

A case-control study on risk factors for unintentional childhood poisoning in Tehran

Background: Poisoning is a major public health problem and is one of the most frequent causes of emergency hospital admissions. The aim of this study was to identify the main risk factors for unintentional childhood poisoning in Tehran, Iran and to suggest possible causes and preventative measures. Methods: In this case-control study (case, n=140; control, n=280), two controls were selected for every case. Controls were matched by age, sex, and date of hospital attendance. All children and their guardians were then interviewed by the same person using a standard questionnaire that covered the demographic, behavioral, and risk factors associated with accidental poisonings. Results: The most common type of poisoning was related to narcotics (58.6); and among the narcotics, methadone was the most prevalent poisoning agent (74.7). Multivariate conditional logistic regression model revealed that addiction in the family (OR=14.6; 95 CI:6.2-34.6), previous poisoning (OR=7; 95 CI:2.4-20.2), maternal occupation (OR=4; 95 CI:1.3-12.3), and inaccessibility of poisoning products (OR=0.03; 95 CI:0.01-0.12) were the main risk factors in unintentional childhood poisoning. Conclusion: Addiction in the family as a risk factor and inaccessibility of poisoning products as a protecting factor were recognized to have the highest correlation with the unintentional child poisoning. These two factors were considered as priorities in health education programs