Changing the Interface of Family and Consumer Sciences at Florida International University

The need to change the interface of the Family and Consumer Sciences (FCS) Program at Florida International University (FlU) has evolved because of changes in our family structure, culture, resources, educational reform, new knowledge in basic disciplines and applied research

Suicide in the indigenous population of latin america : a systematic review

Objetivo Se han reportado altas tasas de suicidio en algunas minorías étnicas, entre ellas comunidades indígenas en Latinoamérica. Este fenómeno se considera un problema de salud pública. Realizamos una revisión sistemática para describirlo. Métodos Se realizó una búsqueda sistemática en las bases de datos de PubMed, Scopus, PscycNET, Scielo y Google Scholar. Resultados Se encontró un total inicial de 1.862 referencias; de estos artículos, se incluyeron 41 para extracción de datos según los criterios de inclusión, de los que 21 hacen referencia a Brasil, 13 a Colombia, 2 a Chile, 1 a Perú y 4 artículos a diferentes países agrupados. Las comunidades indígenas están pasando por un fenómeno de «muerte cultural» en el que los cambios en las culturas, los estilos de vida, la industrialización, la invasión del medio ambiente y el consumo de alcohol se convierten en desencadenantes del suicidio.Q4Artículo de revisión237-242Objective Due to the high rates of suicide reported among many ethnic minorities, a systematic review is presented on suicide in indigenous populations of Latin America. Methods Systematic review in PubMed, Scopus, PsycNET, Scielo and Scholar Google. Results From an initial total of 1862 articles, 41 were included for data extraction. They include 21 from Brazil, 13 from Colombia, 2 from Chile, 1 from Peru, and 4 articles grouped from different countries. Suicide is a public health issue in many communities. Lifestyle changes, industrialisation, environmental degradation, and alcohol have led the indigenous population experiencing what has been described as “cultural death.

Probing the Nature of the G1 Clump Stellar Overdensity in the Outskirts of M31

We present deep HST/ACS observations of the G1 clump, a distinct stellar overdensity lying at ~30 kpc along the south-western major axis of M31 close to the G1 globular cluster (Ferguson et al. 2002). Our well-populated colour-magnitude diagram reaches ~7 magnitudes below the red giant branch tip with 90% completeness, and allows the detection of various morphological features which can be used to derive detailed constraints on the age and metallicity of the constituent stellar population. We find that the colour-magnitude diagram is best described by a population with a large age range (>= 10 Gyr) and a relatively high mean metallicity [M/H]= -0.4. The spread in metallicity is constrained to be <=0.5 dex. The star formation rate in this region has declined over time, with the bulk of the stellar mass having formed >6 Gyr ago. Nonetheless, a non-negligible mass fraction (approximately 10%) of the population has formed in the last 2 Gyr. We discuss the nature of the G1 Clump in light of these new stellar population constraints and argue that the combination of stellar content and physical size make it unlikely that the structure is the remnant of an accreted dwarf galaxy. Instead, the strong similarity between the stellar content of the G1 Clump and that of the M31 outer disk suggests the substructure is a fragment of the outer disk, perhaps torn off from the main body during a past accretion/merger event; this interpretation is consistent with extant kinematical data. If this interpretation is correct, our analysis of the stellar content provides further evidence that the outskirts of large disk galaxies have been in place for a significant time.Comment: Accepted for publication in AJ. 13 pages, 12 figures. Figure 1, 5, 9, and 10 at reduced resolution. High resolution version available at http://www.astro.lu.se/~daniel/g1/g1.p

The Stellar Populations of M31 Halo Substructure

We present the first results from our survey of stellar substructure in the outskirts of M31 using the Advanced Camera for Surveys (ACS) on board the Hubble Space Telescope. We discuss the stellar populations associated with five prominent stellar overdensities discovered during the course of our panoramic ground-based imaging survey with the Isaac Newton Telescope Wide-Field Camera (INT WFC); a sixth pointing targets a region of `clean' halo. The colour-magnitude diagrams (CMDs), which contain between ~10,000--90,000 stars and reach four magnitudes below the horizontal branch, reveal clear variations in morphology between most fields, indicating that the age and/or metallicity mix of stars is not constant at large radius. This directly confirms the existence of large-scale population inhomogeneities within the halo of M31 and lends further support to the notion that M31 has formed, at least in part, through satellite accretions. We find a striking similarity between the populations of the giant stellar stream and those of another overdensity, the NE shelf, which lies north-east of the galaxy center. If these overdensities are associated with the same population, then the difference in their red clump magnitudes implies the NE shelf lies in front of the stream by several tens of kpc, in good agreement with recent orbit calculations for the stream progenitor.Comment: 5 pages, 3 figurs, ApJL accepte

Plant-associated symbiotic Burkholderia species lack hallmark strategies required in mammalian pathogenesis

Burkholderia is a diverse and dynamic genus, containing pathogenic species as well as species that form complex interactions with plants. Pathogenic strains, such as B. pseudomallei and B. mallei, can cause serious disease in mammals, while other Burkholderia strains are opportunistic pathogens, infecting humans or animals with a compromised immune system. Although some of the opportunistic Burkholderia pathogens are known to promote plant growth and even fix nitrogen, the risk of infection to infants, the elderly, and people who are immunocompromised has not only resulted in a restriction on their use, but has also limited the application of non-pathogenic, symbiotic species, several of which nodulate legume roots or have positive effects on plant growth. However, recent phylogenetic analyses have demonstrated that Burkholderia species separate into distinct lineages, suggesting the possibility for safe use of certain symbiotic species in agricultural contexts. A number of environmental strains that promote plant growth or degrade xenobiotics are also included in the symbiotic lineage. Many of these species have the potential to enhance agriculture in areas where fertilizers are not readily available and may serve in the future as inocula for crops growing in soils impacted by climate change. Here we address the pathogenic potential of several of the symbiotic Burkholderia strains using bioinformatics and functional tests. A series of infection experiments using Caenorhabditis elegans and HeLa cells, as well as genomic characterization of pathogenic loci, show that the risk of opportunistic infection by symbiotic strains such as B. tuberum is extremely low

The Star Formation History and Dust Content in the Far Outer Disc of M31

We present a detailed analysis of two fields located 26 kpc (~5 scalelengths) from the centre of M31. One field samples the major axis populations--the Outer Disc field--while the other is offset by ~18' and samples the Warp in the stellar disc. The CMDs based on HST/ACS imaging reach old main-sequence turn-offs (~12.5 Gyr). We apply the CMD-fitting technique to the Warp field to reconstruct the star formation history (SFH). We find that after undergoing roughly constant SF until about 4.5 Gyr ago, there was a rapid decline in activity and then a ~1.5 Gyr lull, followed by a strong burst lasting 1.5 Gyr and responsible for 25% of the total stellar mass in this field. This burst appears to be accompanied by a decline in metallicity which could be a signature of the inflow of metal-poor gas. The onset of the burst (~3 Gyr ago) corresponds to the last close passage of M31 and M33 as predicted by detailed N-body modelling, and may have been triggered by this event. We reprocess the deep M33 outer disc field data of Barker et al. (2011) in order to compare consistently-derived SFHs. This reveals a similar duration burst that is exactly coeval with that seen in the M31 Warp field, lending further support to the interaction hypothesis. The complex SFHs and the smoothly-varying age-metallicity relations suggest that the stellar populations observed in the far outer discs of both galaxies have largely formed in situ rather than migrated from smaller galactocentric radii. The strong differential reddening affecting the CMD of the Outer Disc field prevents derivation of the SFH. Instead, we quantify this reddening and find that the fine-scale distribution of dust precisely follows that of the HI gas. This indicates that the outer HI disc of M31 contains a substantial amount of dust and therefore suggests significant metal enrichment in these parts, consistent with inferences from our CMD analysis.Comment: Abstract shortened. 17 pages, 12 figures (+ 6 pages & 5 figures in Appendix). MNRAS, in pres

HER3 and downstream pathways are involved in colonization of brain metastases from breast cancer

Introduction: Metastases to the brain from breast cancer have a high mortality, and basal-like breast cancers have a propensity for brain metastases. However, the mechanisms that allow cells to colonize the brain are unclear.Methods: We used morphology, immunohistochemistry, gene expression and somatic mutation profiling to analyze 39 matched pairs of primary breast cancers and brain metastases, 22 unmatched brain metastases of breast cancer, 11 non-breast brain metastases and 6 autopsy cases of patients with breast cancer metastases to multiple sites, including the brain.Results: Most brain metastases were triple negative and basal-like. the brain metastases over-expressed one or more members of the HER family and in particular HER3 was significantly over-expressed relative to matched primary tumors. Brain metastases from breast and other primary sites, and metastases to multiple organs in the autopsied cases, also contained somatic mutations in EGFR, HRAS, KRAS, NRAS or PIK3CA. This paralleled the frequent activation of AKT and MAPK pathways. in particular, activation of the MAPK pathway was increased in the brain metastases compared to the primary tumors.Conclusions: Deregulated HER family receptors, particularly HER3, and their downstream pathways are implicated in colonization of brain metastasis. the need for HER family receptors to dimerize for activation suggests that tumors may be susceptible to combinations of anti-HER family inhibitors, and may even be effective in the absence of HER2 amplification (that is, in triple negative/basal cancers). However, the presence of activating mutations in PIK3CA, HRAS, KRAS and NRAS suggests the necessity for also specifically targeting downstream molecules.Ludwig Institute of Cancer ResearchNational Breast Cancer FoundationUniv Queensland, Clin Res Ctr, Brisbane, Qld 4029, AustraliaQueensland Inst Med Res, Brisbane, Qld 4006, AustraliaUniversidade Federal de São Paulo, EPM, Dept Anat Patol, BR-04024000 São Paulo, BrazilGriffith Univ, Brisbane, Qld 4011, AustraliaUniv Queensland, Ctr Magnet Resonance, Brisbane, Qld 4072, AustraliaEijkman Inst, Jakarta 10430, IndonesiaInst Nacl Canc, Dept Patol, BR-20230130 Rio de Janeiro, BrazilLab Salomao & Zoppi, Dept Patol, BR-04104000 São Paulo, BrazilCharles Univ Prague, Fac Med, Dept Pathol, Plzen 30605, Czech RepublicUniv Sydney, Inst Clin Pathol & Med Res, Sydney W Area Hlth Serv, Sydney, NSW 2145, AustraliaUniv Sydney, Westmead Millennium Inst, Sydney W Area Hlth Serv, Sydney, NSW 2145, AustraliaPeter MacCallum Canc Ctr, Dept Pathol, Melbourne, Vic 3002, AustraliaUniv Queensland, Queensland Brain Inst, Brisbane, Qld 4072, AustraliaRoyal Brisbane & Womens Hosp, Brisbane, Qld 4029, AustraliaUniversidade Federal de São Paulo, EPM, Dept Anat Patol, BR-04024000 São Paulo, BrazilWeb of Scienc

The nature and origin of substructure in the outskirts of M31-II. Detailed star formation histories

While wide-field surveys of M31 have revealed much substructure at large radii, understanding the nature and origin of this material is not straightforward from morphology alone. Using deep HST/ACS data, we have derived further constraints in the form of quantitative star formation histories (SFHs) for 14 inner halo fields which sample diverse substructures. In agreement with our previous analysis of colour-magnitude diagram morphologies, we find the resultant behaviours can be broadly separated into two categories. The SFHs of 'disc-like' fields indicate that most of their mass has formed since z~1, with one quarter of the mass formed in the last 5 Gyr. We find 'stream-like' fields to be on average 1.5 Gyr older, with <10 percent of their stellar mass formed within the last 5 Gyr. These fields are also characterised by an age--metallicity relation showing rapid chemical enrichment to solar metallicity by z=1, suggestive of an early-type progenitor. We confirm a significant burst of star formation 2 Gyr ago, discovered in our previous work, in all the fields studied here. The presence of these young stars in our most remote fields suggests that they have not formed in situ but have been kicked-out from through disc heating in the recent past.Comment: 14 pages, 10 figures (+12 figures in appendix). MNRAS, in pres