Chiral Pharmaceutical Intermediaries Obtained by Reduction of 2-Halo-1-(4-substituted phenyl)-ethanones Mediated by Geotrichum candidum CCT 1205 and Rhodotorula glutinis CCT 2182

Enantioselective reductions of p-R1-C6H4C(O)CH2R2 (R1 = Cl, Br, CH3, OCH3, NO2 and R2 = Br, Cl) mediated by Geotrichum candidum CCT 1205 and Rhodotorula glutinis CCT 2182 afforded the corresponding halohydrins with complementary R and S configurations, respectively, in excellent yield and enantiomeric excesses. The obtained (R)- or (S)-halohydrins are important building blocks in chemical and pharmaceutical industries

Recent Advances in the Biocatalytic Asymmetric Reduction of Acetophenones and α.β-Unsaturated Carbonyl Compounds

Whole cells of living organisms, mainly of yeasts, have been used as reliable biocatalysts by synthetic organic chemists to perform redox reactions of various functional groups. This review focuses on the potential of these whole cells to reduce acetophenones and α.β-unsaturated carbonyl compounds (aldehydes and ketones) furnishing relevant chiral building blocks for fine chemicals and the pharmaceutical industries

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Enantioselective reductions of p-R 1 -C 6 H 4 C(O)CH 2 R 2 (R 1 = Cl, Br, CH 3 , OCH 3 , NO 2 and R 2 = Br, Cl) mediated by Geotrichum candidum CCT 1205 and Rhodotorula glutinis CCT 2182 afforded the corresponding halohydrins with complementary R and S configurations, respectively, in excellent yield and enantiomeric excesses. The obtained (R)-or (S)-halohydrins are important building blocks in chemical and pharmaceutical industries