Clinopodium raimondoi (Lamiaceae), a new species from Sicily

On the basis of the taxonomic study of the collections made by F. M. Raimondo, kept in PAL, a new species of Clinopodium is described. The new taxon, named Clinopodium raimondoi, occurs in N-W coast of Sicily on limestone substrata, in steppe communities dominated by Hyparrhenia hirta. The main distinctive characteristics of C. raimondoi, with respect to other taxa known from Europe and other Mediterranean countries, are the large size, the opposite and decussate branches, and the clearly woody at base stems of mature plants as well. Relationships of the new taxon with the Mediterranean ones in the C. nepeta group are also discussed

Comparative pharmacokinetics of amikacin sulphate in calves and sheep.

The pharmacokinetics of amikacin sulphate were investigated in calves and sheep. Five animals of each species were given 7.5 mg kg-1 intravenously and intramuscularly. After intravenous administration the pharmacokinetic parameters significantly different (P less than 0.01) between calves (first value) and sheep (second value), were: the initial concentration (87.05, 146.6 micrograms ml-1), the apparent distribution volume (350, 200 ml kg-1), the area under curve (5512, 11,018 min micrograms ml-1) and the clearance (1.5, 0.7 ml min-1 kg-1). After dosing intramuscularly the peak concentration (23.5, 34.36 micrograms ml-1), the peak time (45, 75 min) and the area under curve (5458, 9191 min micrograms ml-1) were significantly different (P less than 0.01). No significant differences were observed in the terminal halflife values, suggesting that elimination rate was independent of both route of administration and animal species. The drug in aqueous solution showed a good bioavailability in both animal species (about 0.87 in sheep and greater than 0.99 in calves) despite the greater serum concentrations always attained in shee