A study of evacuation efficiency of a hopper-shape exit by using mice under high competition

Exit is the bottleneck of an evacuation from a room and the flow rate through an exit is believed to be depended on its width. A series of experiments were conducted in a bi-dimensional container where mice were driven to pass through two kinds of exit of the identical width, i.e., a conventional exit and a hopper-shape exit. The evacuation efficiency of the two exits was experimentally compared by using mice under competition. The results showed that a hopper-shape exit reduces the escape time by 25% compared with a conventional exit. Further study was conducted with the presence of a column in front of the two exits. The presence of a column in front of the conventional exit increases the escape time by 22.5%. On the contrary, the placement of column in front of the hopper-shape exit reduces the escape time by 48%. The study showed that the escape efficiency could be greatly improved by appropriately redesigning configuration of exit

Distributed control system architecture for deep submergence rescue vehicles

The control architectures of Chuan Suo (CS) deep submergence rescue vehicle are introduced. The hardware and software architectures are also discussed. The hardware part adopts a distributed control system composed of surface and underwater nodes. A computer is used as a surface control machine. Underwater equipment is based on a multi-board-embedded industrial computer with PC104 BUS, which contains IO, A/D, D/A, eight-channel serial, and power boards. The hardware and software parts complete data transmission through optical fibers. The software part involves an IPC of embedded Vxworks real-time operating system, upon which the operation of I/O, A/D, and D/A boards and serial ports is based on; this setup improves the real-time manipulation. The information flow is controlled by the software part, and the thrust distribution is introduced. A submergence vehicle heeling control method based on ballast water tank regulation is introduced to meet the special heeling requirements of the submergence rescue vehicle during docking. Finally, the feasibility and reliability of the entire system are verified by a pool test. Keywords: Deep Submergence Rescue Vehicle (DSRV), Control system, Architecture, Thrust distribution, Water tank regulatio

Numerical Investigation on the Transient Flow of a Boiler Circulating Pump Based on the Shear Stress Transport Turbulence Model

Based on the shear stress transport (SST) turbulence model, the influence of different outlet pipe angles on the head and efficiency of a boiler circulating pump was analyzed. When the outlet pipe angle changed from 115° to 130°, the head and efficiency of the pump reduced significantly. The boiler circulating pump with 115° outlet pipe angle was selected as the further research object, and the reliability of the numerical simulation was verified by experiments. The transient flow of the prototype pump under the design flow rate condition (1.0Qd) and four other flow rate conditions (0.6Qd, 0.8Qd, 1.2Qd, and 1.4Qd) was studied. The results show that, under the conditions of design flow and large flow rate (1.0Qd, 1.2Qd, and 1.4Qd), the centrality and regularity of radial force distribution are obviously better than those of small flow rate (0.6Qd, 0.8Qd). The leakage of the rear seal ring is less than that of the front seal ring under five flow rate conditions. As the flow rate increases, the leakage of front and rear seal rings decreases, and the leakage ratio of front and rear seal rings increases. The energy loss of the rear cover plate is greater than the energy loss of the front cover plate under five flow rate conditions. With the increase in flow rate, the total loss energy of the prototype pump decreases first and then increases, and the energy loss of the disc becomes larger and larger

Effects of Asiaticoside Treatment on the Survival of Random Skin Flaps in Rats

Background: Asiaticoside (AS) is extracted from the traditional herbal medicine Centella asiatica, and has angiogenic, antioxidant, anti-inflammatory, and wound-healing effects. We investigated the effects of AS on skin flap survival. Methods: Dorsal McFarlane flaps were harvested from 36 rats and divided into two groups: an experimental group treated with 40 mg/kg AS administered orally once daily, and a control group administered normal saline in an identical manner. On day 2, superoxide dismutase (SOD) and malondialdehyde (MDA) levels, and production of the cytokines tumor necrosis factor-α and interleukin (IL)-6 were evaluated. On day 7, tissue slices were stained with hematoxylin and eosin. The expression of vascular endothelial growth factor (VEGF), IL-6, and IL-1β were immunohistochemically evaluated. Microcirculatory flow was measured using laser Doppler flowmetry. Flap angiography, using the lead oxide-gelatin injection technique, was performed with the aid of a soft X-ray machine. Results: The AS group exhibited greater mean flap survival area, improved microcirculatory flow, and higher expression levels of SOD and VEGF compared with the control group. However, MDA levels and the inflammatory response were significantly reduced. Conclusions: AS exhibits promise as a therapeutic option due to its effects on the viability and function of random skin flaps in rats

A risk evaluation model of cervical cancer based on etiology and human leukocyte antigen allele susceptibility

Background: There are no reliable risk factors to accurately predict progression to cervical cancer in patients with chronic cervicitis infected with human papillomavirus (HPV). The aim of this study was to create a validated predictive model based on the risk factors for cervical cancer. A model to estimate the risk of cervical cancer may help select patients for intervention therapy in order to reduce the occurrence of cervical cancer after HPV infection. Methods: This retrospective analysis included 68 patients with cervical cancer and 202 healthy female controls. HPV infection and human leukocyte antigen (HLA) class II alleles in HLA-DRB1, 3–7, and 9 were detected. Other information was collected, including level of education and age at first parturition. Multiple regression analysis and an artificial neural network (ANN) were performed to identify the independent risk factors for cervical cancer, and based on these, an evaluation model for the prediction of the incidence of cervical cancer was formed. Results: This model showed HPV to be a pivotal player in cervical cancer that increased the risk by 7.6-fold. The presence of the HLA-DRB1*13-2 and HLA-DRB1*3(17) alleles was associated with an increased risk of developing cervical cancer. Conversely, the HLA-DRB1*09012 and HLA-DRB1*1201 alleles were found to be associated with a reduced cervical cancer risk. In addition, other factors, such as age at first parturition and education level, had significant effects on cervical cancer risk. The model was applied to conduct a risk assessment of women in the mountain area of Wufeng County, Hubei Province in China. The sensitivity and specificity of our model both exceeded 95%. Conclusions: This model, based on etiology and HLA allele susceptibility, can estimate the risk of cervical cancer in chronic cervicitis patients after HPV infection. It combines genetic and environmental factors and significantly enhances the accuracy of risk evaluation for cervical cancer. This model could be used to select patients for intervention therapy and to guide patient classification management

Simulation Experiment of Environmental Impact of Deep-Sea Mining: Response of Phytoplankton Community to Polymetallic Nodules and Sediment Enrichment in Surface Water

In this paper, simulation experiments were conducted to study the response of phytoplankton biomass and community composition to the influence of polymetallic nodules and sediment at four stations in the western Pacific in 2021. Chlorophyll a, pico-phytoplankton cell abundance, and metal concentration were measured before and after 24 h of deck incubation. The results show that there were three different patterns of response, namely, restrained, stimulated, and unaffected patterns. The restrained pattern appeared in the filtered treatments at station Incub.01, and the stimulated pattern appeared in the unfiltered treatments at station Incub.02. The response of the phytoplankton was not detectable at stations Incub.03 and 04. Regardless, positive and negative responses were found in the dominant pico-phytoplankton group—Prochlorococcus—and with slight variation in Synechococcus. The concentration of manganese varied among the treatments compared to that of iron and other metals. The factors affecting the growth of the phytoplankton in this study were metal concentrations and turbidity. The phytoplankton biomass baseline may also have played an important role: the lower the biomass, the higher the growth rate. This study proved that deep-sea polymetallic nodule mining will have a specific impact on surface phytoplankton biomass, but turbidity and particle retention time could be important factors in mitigating the extent of the impact

Aldo-Keto Reductase 1C3 Mediates Chemotherapy Resistance in Esophageal Adenocarcinoma via ROS Detoxification

Simple Summary The multidrug resistance of EAC is one of the major obstacles to chemotherapeutic efficiency. Our study aims to explore the molecular mechanism of AKR1C3 as a novel therapeutic target to overcome chemotherapy resistance for EAC patients. We demonstrate that AKR1C3 renders chemotherapy resistance through controlling cellular ROS levels via AKT signaling in EAC cells. Modulation of intracellular GSH levels by AKR1C3 could scavenge the intracellular ROS, thus regulating apoptosis. Targeting AKR1C3 may represent a novel strategy to sensitize EAC cells to conventional chemotherapy treatment and benefit the overall survival of patients diagnosed with EAC. Esophageal adenocarcinoma (EAC) is one of the most lethal malignancies, and limits promising treatments. AKR1C3 represents a therapeutic target to combat the resistance in many cancers. However, the molecular mechanism of AKR1C3 in the chemotherapy resistance of EAC is still unclear. We found that the mRNA level of AKR1C3 was higher in EAC tumor tissues, and that high AKR1C3 expression might be associated with poor overall survival of EAC patients. AKR1C3 overexpression decreased cell death induced by chemotherapeutics, while knockdown of AKR1C3 attenuated the effect. Furthermore, we found AKR1C3 was inversely correlated with ROS production. Antioxidant NAC rescued chemotherapy-induced apoptosis in AKR1C3 knockdown cells, while the GSH biosynthesis inhibitor BSO reversed a protective effect of AKR1C3 against chemotherapy. AKT phosphorylation was regulated by AKR1C3 and might be responsible for eliminating over-produced ROS in EAC cells. Intracellular GSH levels were modulated by AKR1C3 and the inhibition of AKT could reduce GSH level in EAC cells. Here, we reported for the first time that AKR1C3 renders chemotherapy resistance through controlling ROS levels via AKT signaling in EAC cells. Targeting AKR1C3 may represent a novel strategy to sensitize EAC cells to conventional chemotherapy

Enhancing polyol/sugar cascade oxidation to formic acid with defect rich MnO2 catalysts

Abstract Oxidation of renewable polyol/sugar into formic acid using molecular O2 over heterogeneous catalysts is still challenging due to the insufficient activation of both O2 and organic substrates on coordination-saturated metal oxides. In this study, we develop a defective MnO2 catalyst through a coordination number reduction strategy to enhance the aerobic oxidation of various polyols/sugars to formic acid. Compared to common MnO2, the tri-coordinated Mn in the defective MnO2 catalyst displays the electronic reconstruction of surface oxygen charge state and rich surface oxygen vacancies. These oxygen vacancies create more Mnδ+ Lewis acid site together with nearby oxygen as Lewis base sites. This combined structure behaves much like Frustrated Lewis pairs, serving to facilitate the activation of O2, as well as C–C and C–H bonds. As a result, the defective MnO2 catalyst shows high catalytic activity (turnover frequency: 113.5 h−1) and formic acid yield (>80%) comparable to noble metal catalysts for glycerol oxidation. The catalytic system is further extended to the oxidation of other polyols/sugars to formic acid with excellent catalytic performance