Method for 3D modelling based on structure from motion processing of sparse 2D images

A method based on Structure from Motion for processing a plurality of sparse images acquired by one or more acquisition devices to generate a sparse 3D points cloud and of a plurality of internal and external parameters of the acquisition devices includes the steps of collecting the images; extracting keypoints therefrom and generating keypoint descriptors; organizing the images in a proximity graph; pairwise image matching and generating keypoints connecting tracks according maximum proximity between keypoints; performing an autocalibration between image clusters to extract internal and external parameters of the acquisition devices, wherein calibration groups are defined that contain a plurality of image clusters and wherein a clustering algorithm iteratively merges the clusters in a model expressed in a common local reference system starting from clusters belonging to the same calibration group; and performing a Euclidean reconstruction of the object as a sparse 3D point cloud based on the extracted parameters

Consumer Footprint. Basket of Products indicator on Mobility

The EU Consumer Footprint aims at assessing the environmental impacts of consumption. The methodology for assessing the impacts is based on the life cycle assessment (LCA) of products (or services) purchased and used in one year by an EU citizen. This report is about the subset indicator of the consumer footprint of the basket of product (BoP) on mobility. The baseline model of the BoP mobility is built using statistics about European fleet composition and intensity of use of transport means by European citizens, i.e. the number of kilometers travelled by road, rail and air transport. These data are then allocated to 27 representative products, including 16 types of passenger cars, 3 types of 2-wheelers, 3 types of bus transport, 2 types of rail transport and 3 types of air transport. The resulting baseline inventory model, referring to the year 2010, has been assessed for 15 different impact categories, using the ILCD life cycle impact assessment method. A sensitivity analysis has been run for some impact categories, with a selection of recent impact assessment models and factors. Results allows a wide array of considerations, as this study reports overall impact in Europe due to mobility, average impact per citizen, share of impact due to each transport mode and type of vehicle. The results highlight that road transport is by far the mode of transport contributing the most to the impact of EU citizens’ mobility. Within this macro-category, the product groups that can be considered hotspots for the European mobility are passenger cars, and especially diesel cars. In terms of impact categories, resource depletion is the most important one, especially for road transport (due to the materials used to build the vehicles and the fossil fuels used in the use stage). The contribution of life cycle stages to the overall impact of the BoP mobility varies among impact categories: vehicle usage, fuel production and vehicle production are the most relevant stages for almost all the impact categories considered. To assess potential benefits stemming from selected ecoinnovations applied to the mobility sector, the Consumer Footprint BoP mobility baseline has been assessed against five scenarios. The scenarios developed for the BoP mobility regard the use of eco-driving measures (including technical and behavioural changes), an increased use of biofuels in substitution of the current blend of diesel, and the evolution of hybrid and electric mobility (as the share of hybrid and electric vehicles in the European fleet and of the expected increase in efficiency of the batteries). In addition, one scenario is directly related to changes in the lifestyle of European citizens, namely the shift of a portion of their mobility habits from private cars to public transport, for what concern the mobility in urban areas. The amount of km travelled yearly by European citizens plays a relevant role in the assessment of the scenarios representing possible improvement options for the sector. Indeed, the number of person*km (pkm) travelled yearly by an average European citizen is constantly growing over time. This is reflected in the larger impact (over all the impact categories considered) of the baseline for the reference year 2015 over the baseline 2010 and of scenario 1 (expected situation in 2030) over the baselines 2015 and 2010. The increase of the pkm travelled offsets the reduction of the impact per km travelled achieved through the introduction of cars compliant to the new emission standards (Euro 6) and through the increase of electric and hybrid vehicles. The expected improvements related to electric and hybrid cars, and especially on the batteries, could lead to a reduction of the impact of these type of vehicles up to 40% (e.g. impact of improved electrical vehicle on freshwater eutrophication, compared to the current performance of electrical vehicle). However, the relevance of these improvements on the overall impact of the BoP (i.e. of the mobility of EU citizens) is strongly dependent on the share of vehicles in the fleet. In general, the impact reduction expected from the single solutions tested in the scenarios has a limited effect on the overall impact of the BoP (i.e. of the consumption area of mobility) if they are considered one by one and it is the combination of several measures that may help to maximize the benefits. Specifically for the mobility sector, a reduction of the total kms travelled by road, rail or air means of transport (e.g. by increasing the kms travelled by bicycle or by walking, when possible), is needed, to avoid that the reduction of impact achieved through technological improvements is offset by the continuous increase in the amount of pkm over time.JRC.D.1-Bio-econom

Physicians' knowledge of health-related quality of life and perception of its importance in daily clinical practice

Background: Health-related quality of life (QoL) has become a crucial outcome in medical care. However, few studies have assessed physician knowledge of QoL and rate of physicians adopting QoL measures in clinical practice. The present study aimed at assessing the level of knowledge of QoL and the perceived importance of incorporating QoL assessment in clinical practice among physicians of a tertiary level academic hospital in Rome, Italy. Materials and methods: A survey study performed through the distribution of a questionnaire assessing knowledge of QoL studies that used the SF-36 scale, participation in studies evaluating QoL as well as knowledge of journals publishing articles on QoL Physicians and residents at the hospital Policlinico Gemelli, Catholic University of Rome. Results: Three-hundred nine physicians completed the questionnaire. Thirty-eight percent % reported knowing studies on QoL and using their results in clinical practice or for research purposes; 29% reported knowing the SF-36 questionnaire; 30% stated that at least one study assessing QoL had been conducted in their department. Fourty-six percent % stated that QoL must influence much or very much diagnostic choices and an even higher percentage reported that QoL must influence much or very much therapeutic and palliative strategies (70.8% and 91.3%, respectively). Reported barriers to the use of QoL measures in clinical practice were related to time constraints (8.7%) but also to doubts on methodological issues of QoL (30.7%). The large majority of physicians (94.3%) would have used more expensive drugs if these could improve QoL. Conclusions: The present study shows that in a tertiary level academic italian hospital one third of the physicians, reported to know QoL measures and that more than 80% of them would like to use QoL in their daily clinical practice. Future studies are needed to identify the best strategies to implement the use of QoL measures in clinical practice

Spontaneous vertebral aspergillosis, the state of art: a systematic literature review

Objective: Vertebral aspergillosis are quite rare conditions, often misdiagnosed, that requires long-term antibiotic therapy and, sometimes, surgical treatments. The present investigations was aimed to investigate epidemiology, clinical-radiological aspects, treatment protocols, and outcomes of Aspergillus-mediated vertebral osteomyelitis. Methods: A systematic review of the pertinent English Literature according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines was performed. The research was conducted on Cochrane library, MEDLINE, PubMed and Scopus using as search-terms “Aspergillus”, “vertebral osteomyelitis”, “spondylodiscitis”, “spine infection”. A case of vertebral apsergillosis conservatively managed was also reported. Results: Eighty-nine articles were included in our systematic review. Including the reported case, our analysis covered 112 cases of vertebral aspergillosis. Aspergillus fumigatus was isolated in 68 cases (61.2%), Aspergillus flavus in 14 (12.6%), Aspergillus terreus in 4 (3.6%), Aspergillus nidulans in 2 (1.8%). Seventy-three patients (65.7%) completely recovered at last follow-up evaluation; in 7 (6.3%) patients radiological signs of chronic infection were reported, whereas 32 (28.8%) patients died during the follow-up. Conclusion: This systematic review summarized the state of the art on vertebral aspergillosis, retrieving data on clinical features, diagnostic criteria and current limitations, treatment alternatives and their outcomes

Enriched sera protein profiling for detection of non-small cell lung cancer biomarkers

<p>Abstract</p> <p>Background</p> <p>Non Small Cell Lung Cancer (NSCLC) is the major cause of cancer related-death. Many patients receive diagnosis at advanced stage leading to a poor prognosis. At present, no satisfactory screening tests are available in clinical practice and the discovery and validation of new biomarkers is mandatory. Surface Enhanced Laser Desorption/Ionization Time-of-Flight Mass Spectrometry (SELDI-ToF-MS) is a recent high-throughput technique used to detect new tumour markers. In this study we performed SELDI-ToF-MS analysis on serum samples treated with the ProteoMiner™ kit, a combinatorial library of hexapeptide ligands coupled to beads, to reduce the wide dynamic range of protein concentration in the sample. Serum from 44 NSCLC patients and 19 healthy controls were analyzed with IMAC30-Cu and H50 ProteinChip Arrays.</p> <p>Results</p> <p>Comparing SELDI-ToF-MS protein profiles of NSCLC patients and healthy controls, 28 protein peaks were found significantly different (p < 0.05), and were used as predictors to build decision classification trees. This statistical analysis selected 10 protein peaks in the low-mass range (2-24 kDa) and 6 in the high-mass range (40-80 kDa). The classification models for the low-mass range had a sensitivity and specificity of 70.45% (31/44) and 68.42% (13/19) for IMAC30-Cu, and 72.73% (32/44) and 73.68% (14/19) for H50 ProteinChip Arrays.</p> <p>Conclusions</p> <p>These preliminary results suggest that SELDI-ToF-MS protein profiling of serum samples pretreated with ProteoMiner™ can improve the discovery of protein peaks differentially expressed between NSCLC patients and healthy subjects, useful to build classification algorithms with high sensitivity and specificity. However, identification of the significantly different protein peaks needs further study in order to provide a better understanding of the biological nature of these potential biomarkers and their role in the underlying disease process.</p

Laser remote sensing calibration of ocean color satellite data

world ocean: in fact, those processes dramatically affect the climatic equilibrium of our planet. For this reason, many advanced active and passive remote sensors have been used to study phytoplankton dynamics, since such phenomena are thought to be responsible for the sequestration of atmospheric carbon dioxide, one of the most important greenhouse gases. In this paper, one laser system and three satellite radiometers routinely used for the study of the phytoplankton dynamics will be briefly reviewed. Satellite sensors have been preferred to airborne sensors because, to our knowledge, ocean color airborne radiometers have not been operated in Antarctica, at least not throughout the whole lapse of time examined in this study. Particular focus was on the laser system (ELF) and on a specific satellite radiometer (SeaWiFS). ELF is based on the laser-induced fluorescence of phytoplankton pigments and was conceived for the Italian expeditions to Antarctica. The goal of SeaWiFS is to provide the Earth science community with quantitative data on the global ocean bio-optical properties. Such satellite radiometer has been calibrated with in situ data mainly acquired in non polar regions. This is why a comparison between ELF and SeaWiFS measurements of chlorophyll-a surface concentrations in the Southern Ocean during the austral summer 1997-1998 was believed to be significant. Our results indicate that SeaWiFS overestimates high concentrations and underestimates low concentrations. In order to correct this behavior, the chlorophyll- a bio-optical algorithm of SeaWiFS has been recalibrated according to the measurements of ELF, thus providing a new estimation of the primary production in the Southern Ocean

Ball on a beam: stabilization under saturated input control with large basin of attraction

This article is devoted to the stabilization of two underactuated planar systems, the well-known straight beam-and-ball system and an original circular beam-and-ball system. The feedback control for each system is designed, using the Jordan form of its model, linearized near the unstable equilibrium. The limits on the voltage, fed to the motor, are taken into account explicitly. The straight beam-and-ball system has one unstable mode in the motion near the equilibrium point. The proposed control law ensures that the basin of attraction coincides with the controllability domain. The circular beam-and-ball system has two unstable modes near the equilibrium point. Therefore, this device, never considered in the past, is much more difficult to control than the straight beam-and-ball system. The main contribution is to propose a simple new control law, which ensures by adjusting its gain parameters that the basin of attraction arbitrarily can approach the controllability domain for the linear case. For both nonlinear systems, simulation results are presented to illustrate the efficiency of the designed nonlinear control laws and to determine the basin of attraction

Photosynthetic antenna size in higher plants is controlled by the plastoquinone redox state at the post-transcriptional rather than transcriptional level.

We analyze the effect of the plastoquinone redox state on the regulation of the light-harvesting antenna size at transcriptional and post-transcriptional levels. This was approached by studying transcription and accumulation of light-harvesting complexes in wild type versus the barley mutant viridis zb63, which is depleted in photosystem I and where plastoquinone is constitutively reduced. We show that the mRNA level of genes encoding antenna proteins is almost unaffected in the mutant; this stability of messenger level is not a peculiarity of antenna-encoding genes, but it extends to all photosynthesis-related genes. In contrast, analysis of protein accumulation by two-dimensional PAGE shows that the mutant undergoes strong reduction of its antenna size, with individual gene products having different levels of accumulation. We conclude that the plastoquinone redox state plays an important role in the long term regulation of chloroplast protein expression. However, its modulation is active at the post-transcriptional rather than transcriptional level

Sustainability in peptide chemistry: current synthesis and purification technologies and future challenges.

Developing greener synthesis processes is an inescapable necessity to transform the industrial landscape, mainly in the pharmaceutical sector, into a long-term, sustainable reality. In this context, the renaissance of peptides as medical treatments, and the enforcement of more stringent sustainability requirements by regulatory agencies, pushed chemists toward the introduction of sustainable processes to prepare highly pure, active pharmaceutical ingredients (APIs). Innovative upstream (synthesis) and downstream (purification) methodologies have been developed during the last 5 years with the introduction and optimization of several technologies in solid-phase peptide synthesis (SPPS), liquid-phase peptide synthesis (LPPS), chemoenzymatic peptide synthesis (CEPS), and chromatographic procedures. These innovations are also moving toward the introduction of continuous processes that represent one of the most important targets for iterative processes. This overview discusses the most recent efforts in making peptide chemistry greener. The extensive studies that were carried out on green solvents, reaction conditions, auxiliary reagents and purification technologies in the peptide segment can be useful to other fields of organic synthesi

Critical temperature of non-interacting Bose gases on disordered lattices

For a non-interacting Bose gas on a lattice we compute the shift of the critical temperature for condensation when random-bond and onsite disorder are present. We evidence that the shift depends on the space dimensionality D and the filling fraction f. For D -> infinity (infinite-range model), using results from the theory of random matrices, we show that the shift of the critical temperature is negative, depends on f, and vanishes only for large f. The connections with analogous results obtained for the spherical model are discussed. For D=3 we find that, for large f, the critical temperature Tc is enhanced by disorder and that the relative shift does not sensibly depend on f; at variance, for small f, Tc decreases in agreement with the results obtained for a Bose gas in the continuum. We also provide numerical estimates for the shift of the critical temperature due to disorder induced on a non-interacting Bose gas by a bichromatic incommensurate potential.Comment: 18 pages, 8 figures; Fig. 8 improved adding results for another value of q (q=830/1076