Prevalence of polypharmacy and potentially inappropriate medication use in older lung cancer patients: A systematic review and meta-analysis

Objectives: In older lung cancer patients, polypharmacy and the use of potentially inappropriate medications (PIMs) are commonly reported, but no systematic review or meta-analysis has been carried out to ascertain the prevalence and risk variables in this group. This study aimed to identify the prevalence of polypharmacy, PIMs and associated risk variables in older lung cancer patients.Methods: We searched for articles from the beginning to February 2022 in PubMed, Embase, and Web of Science that related the use of PIMs and polypharmacy by older lung cancer patients (PROSPERO Code No: CRD42022311603). Meta-analysis was performed on observational studies describing the prevalence and correlation of polypharmacy or PIMs in older patients with lung cancer.Results: Of the 387 citations, 6 articles involving 16,890 patients were included in the final sample. In older lung cancer patients pooled by meta-analysis, 38% and 35% of PIMs and polypharmacy, respectively. The prevalence of PIMs was 43%, 49%, and 28%, respectively, according to the 2019 AGS Beers criteria, 2014 screening tool for older people’s prescriptions/screening tool for alerting to the proper therapy (STOPP/START criteria) criteria, and other criteria.Conclusion: This systematic review and meta-analysis demonstrated a high prevalence of polypharmacy and PIMs among older lung cancer patients. Therefore, it is essential to take rational interventions for older lung cancer patients to receive reasonable pharmacotherapy.Systematic Review Registration: [https://www.crd.york.ac.uk/PROSPERO/], identifier [CRD42022311603]

Ba6RE2Ti4O17 (RE= Nd, Sm,Gd, Dy-Yb): A family of quasi-two-dimensional triangular lattice magnets

Rare-earth-based triangular-lattice magnets provide the fertile ground to explore the exotic quantum magnetic state. Herein, we report a new family of RE-based triangular-lattice magnets Ba6RE2Ti4O17(RE= rare earth ions) crystallized into the hexagonal structure with space group of P63 mmc, where magnetic rare earth ions form an ideal triangular lattice within the ab-plane and stack in an AA -type fashion along the c-axis. The low-temperature magnetic susceptibility results reveal all the serial compounds have the dominant antiferromagnetic interactions and an absence of magnetic ordering down to 1.8 K. The magnetization and electron spin resonance results indicate distinct magnetic anisotropy for the compounds with different RE ions. Moreover, Ba6Nd2Ti4O17 single crystal is successfully grown and it exhibits strong Ising like anisotropy with magnetic easy-axis perpendicular to the triangle-lattice plane, being a candidate to explore quantum spin liquid state with dominant Ising-type interaction.Comment: 18 pages, 8 figure

Genome-wide identification and analysis of heterotic loci in three maize hybrids

Heterosis, or hybrid vigour, is a predominant phenomenon in plant genetics, serving as the basis of crop hybrid breeding, but the causative loci and genes underlying heterosis remain unclear in many crops. Here, we present a large-scale genetic analysis using 5360 offsprings from three elite maize hybrids, which identifies 628 loci underlying 19 yield-related traits with relatively high mapping resolutions. Heterotic pattern investigations of the 628 loci show that numerous loci, mostly with complete–incomplete dominance (the major one) or overdominance effects (the secondary one) for heterozygous genotypes and nearly equal proportion of advantageous alleles from both parental lines, are the major causes of strong heterosis in these hybrids. Follow-up studies for 17 heterotic loci in an independent experiment using 2225 F2 individuals suggest most heterotic effects are roughly stable between environments with a small variation. Candidate gene analysis for one major heterotic locus (ub3) in maize implies that there may exist some common genes contributing to crop heterosis. These results provide a community resource for genetics studies in maize and new implications for heterosis in plants

Association mapping of stigma and spikelet characteristics in rice (Oryza sativa L.)

Stigma and spikelet characteristics play an essential role in hybrid seed production. A mini-core of 90 accessions developed from USDA rice core collection was phenotyped in field grown for nine traits of stigma and spikelet and genotyped with 109 DNA markers, 108 SSRs plus an indel. Three major clusters were built upon Rogers’ genetic distance, indicative of indicas, and temperate and tropical japonicas. A mixed linear model combining PC-matrix and K-matrix was adapted for mapping marker-trait associations. Resulting associations were adjusted using false discovery rate technique. We identified 34 marker-trait associations involving 22 SSR markers for eight traits. Four markers were associated with single stigma exsertion (SStgE), six with dual exsertion (DStgE) and five with total exsertion. RM5_Chr1 played major role indicative of high regression with not only DStgE but also SStgE. Four markers were associated with spikelet length, three with width and seven with L/W ratio. Numerous markers were co-associated with multiple traits that were phenotypically correlated, i.e. RM12521_Chr2 associated with all three correlated spikelet traits. The co-association should improve breeding efficiency because single marker could be used to assist breeding for multiple traits. Indica entry 1032 (cultivar 50638) and japonica entry 671 (cultivar Linia 84 Icar) with 80.65 and 75.17% of TStgE, respectively are recommended to breeder for improving stigma exsertion

The genome and transcriptome of Japanese flounder provide insights into flatfish asymmetry

Flatfish have the most extreme asymmetric body morphology of vertebrates. During metamorphosis, one eye migrates to the contralateral side of the skull, and this migration is accompanied by extensive craniofacial transformations and simultaneous development of lopsided body pigmentation(1-5). The evolution of this developmental and physiological innovation remains enigmatic. Comparative genomics of two flatfish and transcriptomic analyses during metamorphosis point to a role for thyroid hormone and retinoic acid signaling, as well as phototransduction pathways. We demonstrate that retinoic acid is critical in establishing asymmetric pigmentation and, via cross-talk with thyroid hormones, in modulating eye migration. The unexpected expression of the visual opsins from the phototransduction pathway in the skin translates illumination differences and generates retinoic acid gradients that underlie the generation of asymmetry. Identifying the genetic underpinning of this unique developmental process answers long-standing questions about the evolutionary origin of asymmetry, but it also provides insight into the mechanisms that control body shape in vertebrates.National Natural Science Foundation of China [31130057, 31461163005, 31530078, 31472269, 31472262, 31472273]; State 863 High Technology R&D Project of China [2012AA092203, 2012AA10A408, 2012AA10A403-2]; Education and Research of Guangdong Province [2013B090800017]; Taishan Scholar Climb Project Fund of Shandong of China; Taishan Scholar Project Fund of Shandong of China for Young Scientists; Shanghai Universities First-class Disciplines Project of Fisheries; Program for Professor of Special Appointment (Eastern Scholar) at the Shanghai Institutions of Higher Learning; Shanghai Municipal Science, Special Project on the Integration of Industryinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/publishedVersio

乙型肝炎相关性肝衰竭患者HBV DNA低水平复制及特异性抗体表达的临床意义

ObjectiveTo investigate the influential factors and clinical significance of low-level hepatitis B virus (HBV) DNA replication and specific antibody expression in patients with HBV-related liver failure. MethodsA retrospective analysis was performed on the medical records of 391 patients with HBV-related liver failure and 394 patients with chronic hepatitis B (CHB) hospitalized in the Tianjin Second People′s Hospital from June 2008 to December 2013. The HBV DNA level was compared between patients with HBV-related liver failure and those with CHB, and the influential factors were analyzed. According to the expression of HBV serum markers (HBV-Ms), patients with liver failure were divided into specific antibody-positive group (positive for anti-HBs, anti-HBe or anti-HBc) and specific antibody-negative group (negative for anti-HBs, anti-HBe or anti-HBc). The changes in HBV DNA level and survival were compared between the two groups. Between-group comparison was made by independent-samples t test or Mann-Whitney rank sum test, and comparison of enumeration data was made by chi-square test. ResultsThe patients with HBV-related liver failure had a significantly lower HBV DNA level than the CHB patients (Z=-16.469, P＜0.05). The levels of HBV DNA in HBeAg-positive and -negative patients with liver failure were significantly lower than those in patients with CHB (Z1=-11.665, P＜005; Z2=-12.853, P＜0.05). Of the 391 patients with HBV-related liver failure, 29 (7.42%) were specific antibody-positive, and 25 (86.21%) of them died; 362 (9258%) were specific antibody-negative, and 157 (43.37%) of them died. There was a significant difference in mortality between the specific antibody-positive and specific antibody-negative groups (P＜0.05). The specific antibody-positive group had a significantly lower HBV DNA level than the specific antibody-negative group (Z=-3.594, P＜0.05). For either group, the HBV DNA level was significantly lower in HBeAg-negative patients than in HBeAg-positive patients (Z=7.427 or 7513, P＜0.05). ConclusionHBV M expression and the body′s immune status play a role in the progression of HBV-related liver failure. HBV DNA replication is at a low level in the immune clearance phase. Being positive for anti-HBs, anti-HBe, and anti-HBc suggest a super immune response to HBV, leading to rapid progression of disease and high mortality

An Ultrasonic Pulse-Echo Method to Detect Internal Defects in Epoxy Composite Insulation

Voids or cracks in basin insulators inside a GIS (gas-insulated metal-enclosed switchgear) could trigger partial discharges or surface flashover under electrical stresses, threatening safe GIS operation. For this paper, some epoxy composite specimens were made from similar materials and manufacturing processes to make 252 kV GIS basin insulators. Some voids with different diameters or cracks with different diameters and orientations were artificially made in the specimens with different thicknesses. An ultrasonic pulse-echo system was set up, and ultrasonic tests were carried out on the specimens with voids or cracks. A method to calculate the depth of a defect was proposed by the propagation time of defect reflected waves. The results showed that a depth of 50 mm, a diameter φ of 2 mm void, and a diameter φ of 1 mm crack in epoxy composite insulation were detected by the ultrasonic system using a 1 MHz transducer

Is There a Difference in Brain Functional Connectivity between Chinese Coal Mine Workers Who Have Engaged in Unsafe Behavior and Those Who Have Not?

(1) Background: As a world-recognized high-risk occupation, coal mine workers need various cognitive functions to process the surrounding information to cope with a large number of perceived hazards or risks. Therefore, it is necessary to explore the connection between coal mine workers’ neural activity and unsafe behavior from the perspective of cognitive neuroscience. This study explored the functional brain connectivity of coal mine workers who have engaged in unsafe behaviors (EUB) and those who have not (NUB). (2) Methods: Based on functional near-infrared spectroscopy (fNIRS), a total of 106 workers from the Hongliulin coal mine of Shaanxi North Mining Group, one of the largest modern coal mines in China, completed the test. Pearson’s Correlation Coefficient (COR) analysis, brain network analysis, and two-sample t-test were used to investigate the difference in brain functional connectivity between the two groups. (3) Results: The results showed that there were significant differences in functional brain connectivity between EUB and NUB among the frontopolar area (p = 0.002325), orbitofrontal area (p = 0.02102), and pars triangularis Broca’s area (p = 0.02888). Small-world properties existed in the brain networks of both groups, and the dorsolateral prefrontal cortex had significant differences in clustering coefficient (p = 0.0004), nodal efficiency (p = 0.0384), and nodal local efficiency (p = 0.0004). (4) Conclusions: This study is the first application of fNIRS to the field of coal mine safety. The fNIRS brain functional connectivity analysis is a feasible method to investigate the neuropsychological mechanism of unsafe behavior in coal mine workers in the view of brain science

Research on the investment Efficiency of Real Estate in Shanxi Province Based on DEA

The investment efficiency of real estate can, to some extent, reflect the development of a province's real estate industry. A good efficiency can also be conducive to economic growth and social stability. This paper uses DEA model to measure the real estate investment efficiency of 11 prefecture-level cities in Shanxi Province from 2017 to 2021, which helps to understand the current state of investment efficiency in Shanxi Province. The results found that the mean value of TE in Shanxi Province is 0.8136, the mean value of PTE is 0.9145, and the mean value of SE is 0.9369, indicating that Shanxi is inefficient and there is still room for improvement