The Role of Postoperative Radiotherapy on Stage N2 Non-small Cell Lung Cancer

Background and objective The clinical value of postoperative radiotherapy (PORT) in stage N2 nonsmall-cell lung cancer (NSCLC) is controversy. The aim of this study is to analyze the efficacy of PORT in subgroup of stage N2 NSCLC, which can help clinicians to choose proper patients for PORT. Methods Clinical data of 359 patients with stage N2 NSCLC treated with radical surgery between Mar. 2000 and Jul. 2005 were retrospectively reviewed. Two hundred and seven patients received adjuvant chemotherapy and one hundred and four patients received adjuvant radiotherapy. First, the group of patients were analyzed to evaluate the factors affecting the overall survival. The all patients were divided based on tumor size and the number of lymph node metastasis station (single station or multiple station) so as to evaluate the role of PORT. The endpoint was overall survival (OS) and local recurrence-free survival (LRFS). Kaplan-Meier method was used to calculate the OS, LRFS and Log-rank was used to compare the difference in OS and LRFS between different groups. Results The median duration of follow-up was 2.3 years. 224 patients died. The median survival was 1.5 years and 1, 3, 5-year survival were 78%, 38% and 26%. Univariate analysis showed tumor size, the number of lymph node metastasis station and PORT were correlated with OS. Among patients, 5-year survival rates in PORT and non-PORT were 29% and 24% (P=0.047) respectively. In subgroups, PORT was related with high survival in patients with multiple station N2 compared to non-PORT: 36% vs 20% (P=0.013) and 33% vs 15% (P=0.002) in patients in patients with tumor size > 3 cm. Also, it was related with low local recurrence compared to non-PORT: 65% vs 48% (P=0.006) and 62% vs 48% (P=0.033). Conclusion PORT can improve overall survival for N2 NSCLC, especially the patients with the factors as follows: tumor size > 3 cm and multiple station N2 can benefit from PORT more or less

Image encryption for Offshore wind power based on 2D-LCLM and Zhou Yi Eight Trigrams

Offshore wind power is an important part of the new power system, due to the complex and changing situation at ocean, its normal operation and maintenance cannot be done without information such as images, therefore, it is especially important to transmit the correct image in the process of information transmission. In this paper, we propose a new encryption algorithm for offshore wind power based on two-dimensional lagged complex logistic mapping (2D-LCLM) and Zhou Yi Eight Trigrams. Firstly, the initial value of the 2D-LCLM is constructed by the Sha-256 to associate the 2D-LCLM with the plaintext. Secondly, a new encryption rule is proposed from the Zhou Yi Eight Trigrams to obfuscate the pixel values and generate the round key. Then, 2D-LCLM is combined with the Zigzag to form an S-box. Finally, the simulation experiment of the algorithm is accomplished. The experimental results demonstrate that the algorithm can resistant common attacks and has prefect encryption performance.Comment: accepted by Int. J. of Bio-Inspired Computatio

Highly Sensitive Twist Sensor Based on Partially Silver Coated Hollow Core Fiber Structure

Interferometer based on multiple beam interferences inside a hollow core fiber (HCF) structure (also known as an antiresonant reflecting optical waveguide) has been attracting interest of many researchers due to its periodic transmission spectrum containing high quality factor spectral dips. Functionalized HCF structures have been demonstrated for a wide range of applications in humidity, magnetic field, and biosensing. Here, we report a new application of the HCF-based structure with a partial silver coating layer for sensing of twist. It is configured by a fusion splicing a section of 4.5-mm long HCF between two standard single mode fibers (SMFs), followed by a sputter-coating of a very thin layer of silver on one side of the HCF surface. It is found that the spectral response of the partially silver coated HCF structure is very sensitive to the changes of input light polarization. An increase in sensitivity of the fiber structure to twist after deposition of the silver coating when the twist is applied to both the SMF and HCF sections is demonstrated by comparison with an uncoated HCF fiber structure. Experimental results show that twisting of the HCF section results in much greater changes in a selected dip\u27s strength compared to that in the case of twisting the SMF section of the structure. The proposed HCF fiber sensors with 4.5-nm and 6.7 nm-thick silver layers show the highest sensitivities of 0.647 dB/°and 0.717 dB/° in the twist angles range of up to 10°. To the best of our knowledge, this is the highest twist sensitivity reported for intensity modulation-based fiber sensors. Moreover, the proposed sensor offers excellent measurement repeatability

Scalable expansion of human pluripotent stem cells under suspension culture condition with human platelet lysate supplementation

The large-scale production of human pluripotent stem cells (hPSCs), including both embryonic stem cells (hESCs) and induced pluripotent stem cells (hiPSCs), shows potential for advancing the translational realization of hPSC technology. Among multiple cell culture methods, suspension culture, also known as three-dimensional (3D) culture, stands out as a promising method to fulfill the large-scale production requirements. Under this 3D culture condition, cell expansion and the preservation of pluripotency and identity during long-term culture heavily relies on the culture medium. However, the xenogeneic supplements in culture medium remains an obstacle for the translation of cell and gene therapy applications from bench to bedside. Here, we tested human platelet lysate (hPL), a xeno-free and serum-free biological material, as a supplement in the 3D culture of hPSCs. We observed reduced intercellular variability and enhanced proliferation in both hESC and hiPSC lines. These cells, after extended culture in the hPL-supplemented system, maintained pluripotency marker expression, the capacity to differentiate into cells of all three germ layers, and normal karyotype, confirming the practicability and safety of hPL supplementation. Furthermore, through RNA-sequencing analysis, we found an upregulation of genes associated with cell cycle regulations in hPL-treated cells, consistent with the improved cellular division efficiency. Taken together, our findings underscore the potential of hPL as a xeno-free and serum-free supplement for the large-scale production of hPSCs, which holds promise for advancing clinical applications of these cells

Highly sensitive twist sensor based on partially silver coated hollow core fiber structure

Interferometer based on multiple beam interferences inside a hollow core fiber (HCF) structure (also known as an anti-resonant reflecting optical waveguide) has been attracting interest of many researchers due to its periodic transmission spectrum containing high quality factor spectral dips. Functionalized HCF structures have been demonstrated for a wide range of applications in humidity, magnetic field and bio-sensing. Here, we report a new application of the HCF based structure with a partial silver coating layer for sensing of twist. It is configured by fusion splicing a section of 4.5-mm long HCF between two standard single mode fibers (SMFs), followed by a sputter-coating of a very thin layer of silver on one side of the HCF surface. It is found that the spectral response of the partially silver coated HCF structure is very sensitive to the changes of input light polarization. An increase in sensitivity of the fiber structure to twist after deposition of the silver coating when twist is applied to both the SMF and HCF sections is demonstrated by comparison with an uncoated HCF fiber structure. Experimental results show that twisting of the HCF section results in much greater changes in a selected dip’s strength compared to that in the case of twisting the SMF section of the structure. The proposed HCF fiber sensors with 4.5 nm and 6.7 nm-thick silver layers show the highest sensitivities of 0.647 dB/°and 0.717 dB/° in the twist angles range of up to 10°. To the best of our knowledge, this is the highest twist sensitivity reported for intensity modulation based fiber sensors. Moreover, the proposed sensor offers excellent measurement repeatability

Primary renal myxoid liposarcoma with pancreatic invasion on 18F-FDG PET/CT: first case report and literature review

BackgroundMyxoid liposarcoma (MLS) is a rare malignant soft tissue sarcoma that predominantly manifests in the deep soft tissues of the extremities, particularly within the musculature of the thigh. Unlike other types of liposarcoma, MLS demonstrates a propensity for metastasis to atypical sites, including the lung parenchyma, soft tissues, retroperitoneum, mediastinum, breast, liver, thymus, lymph nodes, and bones. The definitive diagnosis primarily relies on histology with HE staining. Imaging modalities such as ultrasound, CT, MRI, and 18F-FDG PET/CT scans serve as valuable tools for tumor identification.Case reportA 57-year-old man presented with symptoms of abdominal distention and vomiting 1 month ago. Contrast-enhancement CT revealed a heterogeneous hypodense mass in the upper-middle part of the left kidney, displaying irregular morphology and protrusion towards the exterior of the kidney, with abundant blood supply and had a maximum dimension of approximately 10.7 cm × 9.0 cm. Additionally, a rounded soft tissue density was identified in the pancreatic body. Multiplanar reconstruction demonstrated a connection between the pancreatic lesion and the kidney mass. 18F-FDG PET/CT was conducted for staging, revealing significant growth of the lesion in the upper-middle part of the left kidney, extending beyond the kidney and infiltrating the pancreatic body. The lesion demonstrated remarkably high 18F-FDG uptake (SUVmax = 10.2, MTV = 136.13 cm3, TLG = 484.62). The postoperative pathological examination confirmed the diagnosis of MLS. On the 10th day post-surgery, the patient presented with tumor recurrence and underwent another surgical resection. Unfortunately, during the operation, the patient experienced a sudden cardiac arrest and died.ConclusionRenal MLS with invasion into the pancreas is very rare in clinical practice. Due to the limited research on the utilization of 18F-FDG PET/CT in this particular context, given the rarity and low incidence of MLS, its role remains largely unexplored. As PET/CT imaging becomes increasingly prevalent, thorough imaging of disease sites becomes indispensable for the development of treatment protocols and the monitoring of treatment response

Hollow core fiber based interferometer for high temperature (1000 °C) measurement

A simple, cost effective high temperature sensor (up to 1000 °C) based on a hollow core fiber (HCF) structure is reported. It is configured by fusion splicing a short section of HCF with a length of few millimeters between two standard single mode fibers (SMF-28). Due to multiple beam interference introduced by the cladding of the HCF, periodic transmission dips with high spectral extinction ratio and high quality (Q) factor are excited. However, theoretical analysis shows that minor variations of the HCF cladding diameter may result in a significant decrease in the Q factor. Experimental results demonstrate that the position of periodic transmission dips are independent of the HCF length, but spectral Q factors and transmission power varies with different HCF lengths. A maximum Q factor of 3.3×104 has been demonstrated with large free spectral range of 23 nm and extinction ratio of 26 dB. Furthermore, the structure is proved to be an excellent high temperature sensor with advantages of high sensitivity (up to 33.4 pm/°C), wide working temperature range (from room temperature to 1000°C), high resolution, good stability, repeatability, relatively low strain sensitivity (0.46 pm/με), low cost and a simple and flexible fabrication process that offers a great potential for practical applications. A thorough theoretic analysis of the HCF based fiber structure has been proposed. The experimental results are demonstrated to be well matched with our simulation results

Ultrahigh Thermoelectric Performance by Electron and Phonon Critical Scattering in Cu 2 Se 1‐x I x

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/102251/1/adma201302660.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/102251/2/adma201302660-sup-0001-S1.pd

Modeling the dosimetry of organ-at-risk in head and neck IMRT planning: An intertechnique and interinstitutional study

Purpose: To build a statistical model to quantitatively correlate the anatomic features of structures and the corresponding dose-volume histogram (DVH) of head and neck (HN) Tomotherapy (Tomo) plans. To study if the model built upon one intensity modulated radiation therapy (IMRT) technique (such as conventional Linac) can be used to predict anticipated organs-at-risk (OAR) DVH of patients treated with a different IMRT technique (such as Tomo). To study if the model built upon the clinical experience of one institution can be used to aid IMRT planning for another institution