CCL13 and human diseases

CCL13/MCP-4 belongs to the CC chemokine family, which induces chemotaxis in many immune cells. Despite extensive research into its function in numerous disorders, a thorough analysis of CCL13 is not yet accessible. The role of CCL13 in human disorders and existing CCL13-focused therapies are outlined in this study. The function of CCL13 in rheumatic diseases, skin conditions, and cancer is comparatively well-established, and some studies also suggest that it may be involved in ocular disorders, orthopedic conditions, nasal polyps, and obesity. We also give an overview of research that found very little evidence of CCL13 in HIV, nephritis, and multiple sclerosis. Even though CCL13-mediated inflammation is frequently linked to disease pathogenesis, it’s fascinating to note that in some conditions, like primary biliary cholangitis (PBC) and suicide, it might even act as a preventative measure

Heat Source Forecast of Ball Screw Drive System Under Actual Working Conditions Based on On-Line Measurement of Temperature Sensors

In view of the time-varying complexity of the heat source for the ball screw feed system, this paper proposes an adaptive inverse problem-solving method to estimate the time-varying heat source and temperature field of the feed system under working conditions. The feed system includes multiple heat sources, and the rapid change of the moving heat source increases the difficulty of its identification. This paper attempts to develop a numerical calculation method for identifying the heat source by combining the experiment with the optimization algorithm. Firstly, based on the theory of heat transfer, a new dynamic thermal network model was proposed. The temperature data signal and the position signal of the moving nut captured by the sensors are used as input to optimize the solution of the time-varying heat source. Then, based on the data obtained from the experiment, finite element software parametric programming was used to optimize the estimate of the heat source, and the results of the two heat source prediction methods are compared and verified. The other measured temperature points obtained by the experiment were used to compare and verify the inverse method of this numerical calculation, which illustrates the reliability and advantages of the dynamic thermal network combined with the genetic algorithm for the inverse method. The method based on the on-line monitoring of temperature sensors proposed in this paper has a strong application value for heat source and temperature field estimation of complex mechanical structures

A two-dimensional mid-infrared optoelectronic retina enabling simultaneous perception and encoding

Infrared machine vision system for object perception and recognition is becoming increasingly important in the Internet of Things era. However, the current system suffers from bulkiness and inefficiency as compared to the human retina with the intelligent and compact neural architecture. Here, we present a retina-inspired mid-infrared (MIR) optoelectronic device based on a two-dimensional (2D) heterostructure for simultaneous data perception and encoding. A single device can perceive the illumination intensity of a MIR stimulus signal, while encoding the intensity into a spike train based on a rate encoding algorithm for subsequent neuromorphic computing with the assistanceofanall-opticalexcitationmechanism, a stochastic near-infrared (NIR) sampling terminal. The device features wide dynamic working range, high encoding precision, and flexible adaption ability to the MIR intensity. Moreover, an inference accuracy more than 96% toMIR MNIST data set encoded by the device is achieved using a trained spiking neural network (SNN).Agency for Science, Technology and Research (A*STAR)Ministry of Education (MOE)National Medical Research Council (NMRC)National Research Foundation (NRF)Published versionThis work was supported by the Singapore Ministry of Education (MOE-T2EP50120-0009 (Q.J.W.)), Agency for Science, Technology and Research (A*STAR) (A18A7b0058 (Q.J.W.) and A2090b0144 (Q.J.W.)), National Medical Research Council (NMRC) (021528- 00001 (Q.J.W.)), and National Research Foundation Singapore (NRF-CRP22-2019-0007 (Q.J.W.)), National Key Research and Development Program of China (2022YFB2802803 (N.C.)), the Natural Science Foundation of China Project (61925104 (N.C.), 62031011 (N.C.)) and Major Key Project of PCL (N.C.), and F.H. acknowledges the support from the China Scholarship Council

A two-dimensional mid-infrared optoelectronic retina enabling simultaneous perception and encoding

Designing an infrared machine vision system that can efficiently perceive, convert, and process a massive amount of data remains a challenge. Here, the authors present a retina-inspired 2D optoelectronic device based on van der Waals heterostructure that can perform the data perception and spike-encoding simultaneously for night vision, sensing, spectroscopy, and free-space communications