16 research outputs found
Evaluation of nanocarrier targeted drug delivery of capecitabine-PAMAM dendrimer complex in a mice colorectal cancer model
Get PDFCapecitabine, an effective anticancer drug in colorectal cancer chemotherapy, may create adverse side effects on healthy tissues. In the present study, we first induced colon adenocarcinoma with azoxymethane, a carcinogen agent, and then investigated the potentiality of polyamidoamine (PAMAM) dendrimer to improve capecitabine therapeutic index and decrease its adverse side effects on healthy tissues like liver and bone marrow. Other variables such as nanoparticle concentrations have also been investigated. Drug loading concentration (DLC) and encapsulation efficiency (EE) were calculated for capecitabine/dendrimer complex. Experimental results showed an increase in DLC percentage resulted from elevated capecitabine/dendrimer ratio. Capecitabine/dendrimer complex could reduce tumor size and adverse side effects in comparison with free capecitabine form. © 2016 Tehran University of Medical Sciences. All rights reserved
Intelligent controller for hybrid force and position control of robot manipulators using RBF neural network
No full textSilicon and Potassium Nutrition Enhances Salt Adaptation Capability of Sunflower by Improving Plant Water Status and Membrane Stability
No full textThe role of matrix metalloproteinase-9 as a prognostic biomarker in papillary thyroid cancer
No full textCD9-Positive Microvesicles Mediate the Transfer of Molecules to Bovine Spermatozoa during Epididymal Maturation
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Exploring Serum Levels of Brain Derived Neurotrophic Factor and Nerve Growth Factor Across Glaucoma Stages
No full textReproductive toxicity after levetiracetam administration in male rats: Evidence for role of hormonal status and oxidative stress
No full textDifferences on photosynthetic limitations between leaf margins and leaf centers under potassium deficiency for Brassica napus L.
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