The Research on New Town Development Strategy in Metropolitan Outskirts: A Case Study of Liangzhu New Town

New Towns in the outskirts of city has existed for a moment within the period of China urbanization, and lots of experiences are accumulated during the practices while building this system. This essay is mainly established by the first multifunctional outskirt town, as well as the research object --- Liangzhu New Town, and it also make dicussions and summaries about the concept of design, the structure of this project, the operation process, the mode of operation and etc. Overall, by combining the objective requirements of the outskirts new town development, which is affected by the metropolitan suburbanization, this paper explores a smart way in the construction of the new style urbanization, as well as the solution to the problems which may happen during the construction of the outskirts new town

Effective modulus of polycrystalline aggregates in different geometrical configurations

In the present study, a finite element scheme with random distribution strategy is employed to systematically investigate the modulus difference of polycrystalline copper aggregates in different geometrical configurations (three-dimensional bulk and thin film configurations). Firstly, the finite element simulation is performed to estimate the effective elastic constants in three-dimensional bulk configuration. The numerical estimations are in good agreement with the existing analytical solutions and experimental measurements. Secondly, the proven finite element scheme is extended to the prediction of the effective moduli of the free-standing and substrate-attached thin films. For the free-standing thin film, the effective Young's modulus decreases with reducing the film thickness. For the substrate-attached thin film, its effective modulus is affected by the relative stiffness between the substrate and the film. The spread of the effective moduli in different configurations could be as large as 20%. © 2010 Elsevier B.V.postprin

Electric assumptions for piezoelectric laminate analysis

In computational analysis of piezoelectric laminates which may comprise piezoelectric and non-piezoelectric plies, the transverse electric field is often assumed to be piecewise constant along the transverse direction. This conventional assumption may lead to significant errors unless the piezoelectric ply is considerably thinner than the overall thickness of the laminate. To this end, two alternate assumptions termed EL and DC on the spatial distributions of the electric variables are proposed. In EL, the transverse electric field is taken to be piecewise linear along the transverse direction. In the DC assumption, the transverse electric displacement is taken to be piecewise constant along the transverse direction. The rationales leading to the proposed assumptions are discussed. Numerical examples indicate that the proposed assumptions are markedly more accurate than the conventional one. However, EL becomes inaccurate when its piecewise function spans more than one ply. In this light, DC often consumes less electric potential d.o.f.s and is more efficient than EL. © 2003 Elsevier Ltd. All rights reserved.postprin

Electrocatalytic Activity of Electropolymerized Cobalt Tetraaminophthalocyanine Film Modified Electrode towards 6-Mercaptopurine and 2-Mercaptobenzimidazole

The electrocatalytic activity of electropolymerized cobalt tetraaminophthalocyanine (poly-CoTAPc) film modified on the glassy carbon electrode (GCE) towards 6-mercaptopurine (6MP) and 2-Mercaptobenzimidazole (MBI) was studied. Comparing with the case at the unmodified GCE, the poly-CoTAPc film decreased the overpotential of oxidation of 6MP (1.0 × 10–3 mol L–1) and MBI (1.0×10–3 mol L–1) by 335 and 189mV, respectively, and increased the peak current by about 3 and 2 times, respectively, while the reduction potential of the disulphide product of previous oxidation of 6MP shifted positively by 312 mV and the peak current increased by 40 times in 0.1 mol L–1 phosphate buffer solution (PBS, pH = 2.0). The poly-CoTAPc film exhibited efficiently electrocatalytic activity for 6MP and MBI with relatively high sensitivity, stability and long-life.Keywords: Electrocatalysis, 6-mercaptopurine, 2-mercaptobenzimidazole, Cobalt Tetraaminophthalocyanine, Electropolymeric Fil

Synthesis of new dendritic chiral binol ligands and their applications in enantioselective lewis acid catalyzed addition of diethylzinc to aldehydes

2002-2003 > Academic research: refereed > Publication in refereed journalVersion of RecordPublishe

Accurate prediction of heat of formation by combining Hartree-Fock/density functional theory calculation with linear regression correction approach

A linear regression correction (LRC) approach was developed to account for the electron correlation energy missing in Hartree-Fock (HF) calculation. This method was applied to evaluate the standard heats of formation of 180 small-sized to medium-sized organic molecules at 298.15 K. The descriptors in the LRC scheme are the number of lone-pair electrons, bonding electrons and inner layer electrons in molecules, and the number of unpaired electrons in ground state atoms. It is observed that the large systematic deviations for the calculated heat of formation are reduced drastically, in particular, for the HF results.published_or_final_versio

Curcumin Enhances Bortezomib Treatment of Myeloma by Inhibiting Heat Shock Protein 90 Expression

Purpose: To investigate whether curcumin augments bortezomib-induced apoptosis in myeloma cells (MM1.R line), and to explore the molecular mechanism with regard to heat shock protein 90 (HSP90) expression.Methods: MTT cell viability assay was used to assess growth inhibition of MM1.R cells at different concentrations of curcumin alone and also combined with 0.01 mM bortezomib. Annexin V and propidium iodide (PI) labeling were used to detect apoptosis. Caspase 3, caspase 9, NF-κB, and HSP 90 protein expression were measured by Western blotting.Results: Curcumin alone inhibited MM1.R cell growth and increased apoptosis in a concentration dependent manner. When curcumin was combined with low concentration (0.01 mM) bortezomib, both effects（viability inhibition and apoptosis induction increased (p < 0.05), whereas bortezomib alone had no effect (p > 0.05). Western blotting revealed that for curcumin and combined treatments, expression of the apoptotic markers, caspase 3 and caspase 9, increased while expression of NF-κB and HSP 90 decreased (p < 0.05). Again, low concentration bortezomib alone had no effect, whereas the combined treatment showed the largest effect, thus suggesting that the actions of curcumin and bortezomib are synergistic.Conclusion: Curcumin increased MM1.R cell sensitivity to bortezomib, which may be due to suppression of NF-κB and HSP90 activity.Keywords: Curcumin, Bortezomib, Myeloma cells, Cell growth, Apoptosis, Heat shock protein 9

Specific inhibition of cyclooxygenase-2 down-regulates NF-kappaB activation in gastric cancer cells by blocking its nuclear translocation

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