Effects of Arbuscular Mycorrhizal Fungi on Root Growth and Architecture of Tulip Gesneriana

Arbuscular mycorrhizal fungi(AMF) can promote the absorption of soil water and mineral nutrients, improve photosynthesis, and make host attain higher quality finally by establishing symbiotic relationship between AMF and host root. To improve Tulip gesneriana quality have practical meaning under no bad affect to cultivation soil, in the light of its economical and ecological values. However, some AMF may be diverse from others, the concrete function of AMF on commercial tulip varieties need to explore. Therefore, three different sets of  arbuscular mycorrhizal fungi were inoculated into tulip rhizosphere soil, which were set as 4(Diversispora versiformis), 7(Diversispora spurca) and 1 + 3 + 4 (Rhizophagus intraradias + Funneliformis mosseae + Diversispora versiformis), respectively. The results showed that the activity of most of the measured indices increased, the average root diameter and sucrose content decreased in those three mycorrhizal treatments. Our research provide some theoretical basis for the application of AMF on T.gesneriana ecological cultivation in future

An extensive study of blazar broad emission line: Changing-look blazars and Baldwin effect

It is known that the blazar jet emissions are dominated by non-thermal radiation while the accretion disk jets are normally dominated by thermal emission. In this work, our aim is to study the connection between the two types of emission by investigating the correlation between the blazar emission line intensity property, which embodies the nature of accretion disk, and the $\gamma$-ray flux property, which is the representative of jet emission. We compiled a sample of 656 blazars with available emission line equivalent widths ($EW$), the GeV $\gamma$-ray flux, and the SED information from the literature. In this work, we found 55 previous BCUs are now identified as FSRQs, and found 52 Changing-look blazars based on their $EW$ and 45 of them are newly confirmed. These Changing-look blazars have a larger accretion ratio (${\dot M}/{\dot M}_{\rm Edd}$) than BL Lac objects. In addition, we suggest that the lower synchrotron peak blazars (LSPs) could be the source of Changing-look blazars because 90.7\% of the Changing-look blazars in this work are confirmed as LSPs. An anti-correlation between $EW$ and continuum intensity, the so-called global Baldwin effect (BEff) has been confirmed. We suggest the steeper global BEff observed for blazar than for radio-quiet active galactic nuclei (RQ-AGNs) is caused by the inverse Compton scattering of broad-emission-line photons. This interpretation is further supported by the positive correlation between the emission line $EW$ and intrinsic inverse Compton luminosity.Comment: Accepted to Ap

The Role of Butyric Acid in Treatment Response in Drug-Naive First Episode Schizophrenia

Background: Butyric acid, a major short-chain fatty acid (SCFA), has an important role in the microbiota-gut-brain axis and brain function. This study investigated the role of butyric acid in treatment response in drug-naive first episode schizophrenia. Methods: The study recruited 56 Chinese Han schizophrenia inpatients with normal body weight and 35 healthy controls. Serum levels of butyric acid were measured using Gas Chromatography-Mass Spectrometer (GC-MS) analysis at baseline (for all participants) and 24 weeks after risperidone treatment (for patients). Clinical symptoms were measured using the Positive and Negative Syndrome Scale (PANSS) for patients at both time points. Results: At baseline, there was no significant difference in serum levels of butyric acid between patients and healthy controls (p = 0.206). However, there was a significant increase in serum levels of butyric acid in schizophrenia patients after 24-week risperidone treatment (p = 0.030). The PANSS total and subscale scores were decreased significantly after 24-week risperidone treatment (p\u27s \u3c 0.001). There were positive associations between baseline serum levels of butyric acid and the reduction ratio of the PANSS total and subscale scores after controlling for age, sex, education, and duration of illness (p\u27s \u3c 0.05). Further, there was a positive association between the increase in serum levels of butyric acid and the reduction of the PANSS positive symptoms subscale scores (r = 0.38, p = 0.019) after controlling for potential confounding factors. Conclusions: Increased serum levels of butyric acid might be associated with a favorable treatment response in drug-naive, first episode schizophrenia. The clinical implications of our findings were discussed

Neddylation inhibitor MLN4924 suppresses cilia formation by modulating AKT1

Abstract The primary cilium is a microtubule-based sensory organelle. The molecular mechanism that regulates ciliary dynamics remains elusive. Here, we report an unexpected finding that MLN4924, a small molecule inhibitor of NEDD8-activating enzyme (NAE), blocks primary ciliary formation by inhibiting synthesis/assembly and promoting disassembly. This is mainly mediated by MLN4924-induced phosphorylation of AKT1 at Ser473 under serum-starved, ciliary-promoting conditions. Indeed, pharmaceutical inhibition (by MK2206) or genetic depletion (via siRNA) of AKT1 rescues MLN4924 effect, indicating its causal role. Interestingly, pAKT1-Ser473 activity regulates both ciliary synthesis/assembly and disassembly in a MLN4924 dependent manner, whereas pAKT-Thr308 determines the ciliary length in MLN4924-independent but VHL-dependent manner. Finally, MLN4924 inhibits mouse hair regrowth, a process requires ciliogenesis. Collectively, our study demonstrates an unexpected role of a neddylation inhibitor in regulation of ciliogenesis via AKT1, and provides a proof-of-concept for potential utility of MLN4924 in the treatment of human diseases associated with abnormal ciliogenesis.https://deepblue.lib.umich.edu/bitstream/2027.42/148214/1/13238_2019_Article_614.pd