Treatment of Helicobacter Pylori in Children

Childrenwith Helicobacter infection need treatment. The aim of treatment is elimination of H.Pylori. Most patients with this infection are asymptomatic and without peptic disease. Treatment and management of these patients are controversy. Conventional Treatment: The best treatment for H. pylori eradication regimens should have cure rates of at least 80%, be without major side effects, and induce minimal bacterial resistance. Antibiotics alone have not achieved this. Luminal acidity influences both the effectiveness of some antimicrobial agents and the survival of the bacteri; thus antibiotics have been combined with acid suppression such as proton pump inhibitors (PPIs), bismuth, or H2 antagonists. The “classic” regimen is treatment twice daily for 7 days with a PPI and clarithromycin plus either amoxicillin or metronidazole Bismuth has been used in the treatment of peptic ulcer disease and 1 part o quadruple therapy for H.Pylori but compliance of children for it is low.   Sequential Therapy  Sequential therapyinvolves dual therapy with a PPI and amoxicillin for 5 days followed sequentially by clarithromycin, Tinidazole and omeperazole for 5 days or other triple therapy for 7 days. This treatment has had 97% efficacy.   Adjunctive Therapies A number of studies have showed the potential benefits of probiotic therapy in H. pylori treatment regimens.Consumption of these drugs accompanied with other medications increase H.Pylori eradication.  

Scaling effects for flow in micro-channels: Variable property, viscous heating, velocity slip, and temperature jump

This paper reports closed form solutions, based on perturbation techniques, for fully developed, both hydrodynamically and thermally, slip-flow forced convection in both parallel plate and circular microchannels subject to isothermal wall boundary condition. Scaling effects, including variable property, viscous dissipation, velocity slip, and temperature jump are studied in detail. The results are not only applicable to gaseous flow in the slip-flow regime but also can be used for no-slip liquid flow in microchannels

Effects of thermal boundary condition, fin size, spacing, tip clearance, and material on pressure drop, heat transfer, and entropy generation optimization for forced convection from a variable-height shrouded fin array

Fully developed forced convection through a variable-height shrouded fin array is studied numerically. Two different base thermal boundary conditions are considered being isothermal and isoflux heating. In either case, the shroud is assumed to be adiabatic. Following the application of two separate thermal energy equations, the conjugate heat transfer problem is solved. Different fin material, spacing, height, tip clearance, and size are examined. Considering these effects, pressure drop, heat transfer, and entropy generation aspect of the problem are studied in detail