I liposarcomi retroperitoneali

Il liposarcoma è l’istotipo più frequente tra i rari tumori maligni del retroperitoneo. Tale neoplasia ha la spiccata tendenza a recidivare dopo asportazione chirurgica, raramente a metastatizzare. La recidi - va mostra generalmente un comportamento più aggressivo della malattia primitiva con maggiore tendenza ad infiltrare gli organi vicini. La sintomatologia compare spesso tardivamente ed il segno di esordio è molto frequentemente la massa addominale palpabile. Lo studio preoperatorio implica l’uso della TC e della RMN. La terapia vede nelle chirurgia resettiva o citoriduttiva l’unico strumento in grado di modificare la storia naturale in termini di sopravvivenza e di recidiva locale. La prognosi è severa, con una sopravvivenza a 5 anni variabile tra il 12 ed il 50% nelle varie casi - stiche. Fattori prognostici importanti sono il grado della neoplasia ed il trattamento chirurgico radicale. Dal 1990 al 2001 sono stati eseguiti presso l’U.O. degli Autori 32 interventi per neoplasie maligne del retroperitoneo su 19 pazien - ti, in 7 di questi la neoplasia era un liposarcoma (4 uomini e 3 donne). Il numero complessivo di interventi per liposarcoma retrope - ritoneale è stato di 15. Quattro pazienti sono stati sottoposti ad un secondo intervento per recidiva, di questi 3 ad un terzo intervento ed 1 ad un quarto. In 11 casi su 15 è stata eseguita una exeresi della neoplasia. La sopravvivenza media è stata di 4 anni e 2 mesi. La radioterapia intraoperatoria, eseguita in 3 pazienti, sembra poter offrire dei vantaggi sul controllo locale della malattia e quindi sulla sopravvivenza. Un follow-up precoce con TC e RMN è giustificato dalla possibile resecabilità delle eventuali recidive

COVID-19 and the impact on the cranio-oro-facial trauma care in Italy: An epidemiological retrospective cohort study

The coronavirus disease 2019 (COVID-19) has deeply modified the organization of hospitals, health care centers, and the patient’s behavior. The aim of this epidemiological retrospective cohort study is to evaluate if and how the COVID-19 pandemic has determined a modification in cranio-oro-facial traumatology service. Methods: The dataset included hospital emergency room access of a six-month pre-pandemic period and six months into pandemic outbreak. The variables collected were: patient age, gender, type of emergency access with relative color code, Glasgow Coma Scale Score, type of discharge. Results: 537 vs 237 (pre-pandemic vs pandemic) patients accessed the hospital emergency room and the mean age decreased from 60.79 ± 25.34 to 56.75 ± 24.50 year. Yellow and green code access went from 28.9% and 66.1% to 37.5% and 57.7% (pre-pandemic vs pandemic). Glasgow Coma Scale (GCS) shows an increase of 16.6% vs 27.8% of 15 grade score, a 28.7% vs 28.5% of the 14 grade score and reduction of 13 and 12 grade 40.2% and 14.5% vs 37.1 and 9.7% (pre-pandemic vs pandemic). Conclusions: Since the COVID-19 outbreak continues, epidemiological data are still necessary to perform public health intervention strategies and to appropriately predict the population needs, in order to properly manage the COVID-19 related to oral pathologies as well as the most common health problems

Food Selectivity in Children with Autism Spectrum Disorder: A Statistical Analysis in Southern Italy

This paper focuses on autism spectrum disorder (ASD) and food selectivity, both of which are prevalent in the pediatric population. In this context, the authors paid attention to food selectivity and its possible correlation with the atypicality of sensory processes, outlining the useful rehabilitation treatments to draw on. This research included the parents or caregivers of pediatric patients diagnosed with autism spectrum disorder and placed within a therapeutic clinic. The sample is composed of 111 children, males and females, aged between 2 and 10 years, and includes 60 children diagnosed with autism and 51 children with normotypical development, similar in characteristics but without the disorder. The standardized questionnaire, “Brief Autism Mealtime Behavior Inventory”, was developed to examine behavior during meals, especially in children with ASD. The “Brief Sensory Profile”, and the “Child Oral and Motor Proficiency Scale”, were also administered. The results obtained from the analysis lead to evidence of eating and food selectivity difficulty. Additionally, our study demonstrates that food selectivity can be caused by extreme sensory modulation and sensory problems related to the smell, texture, color, and temperature of food. In fact, the results obtained emphasize the correlation between food selectivity and the sensory domains of taste and smell. Furthermore, this research highlights a correlation between motor skills and eating skills, particularly regarding food selectivity, which is closely associated with atypical and disruptive behaviors during meals

Economical Evaluation of the Sustain Program for the Out-of-Hospital Administration of Abatacept for Rheumatoid Arthritis

Background: The introduction of biological therapies has greatly improved treatment of rheumatoid arthritis (RA) and patients' quality of life. Abatacept is a biological drug that can be given every 28 days by Intravenous Infusion (IvI). IvI administration takes a short period of time and does not require pre-medications nor specific post-infusion support. These characteristics allowed the launch of the SuSTAin Program for the out-of-hospital administration of abatacept IvI.Object: The main aim of this analysis was to assess the economic value generated by the SuSTAin Program for rheumatology centres and the Italian National Health Service (INHS).Methods: Using the SuSTAin database and supported by a Delphi panel of eleven Italian rheumatology experts - one from each participating centre - we collected data about infusion duration and costs of IvI administration (nurse and rheumatologist)/control visit (rheumatologist). The analysis evaluated the saving generated by the SuSTAin Program for the INHS (avoided refunds by INHS to rheumatology centres) and patient's adherence to IvI administrations in the SuSTAin Program. Costs were assessed in Euros 2015.Results: From December 2010 to August 2015, eleven Italian rheumatology centres adopted the SuSTAin Program and 2,856 infusions were given to 135 patients. In each centre, an infusion was shown to take approximately 123.7 minutes and a control visit 30 minutes. Based on the average hourly wage of a rheumatologist and a nurse and the time they dedicate to the infusion, the mean cost per infusion was (sic)66.71. The potential saving for rheumatology centres amounted to (sic)194,134, while the real saving for INHS was (sic)32,234. Data showed a high level of patients' adherence (97%).Conclusions: The SuSTAin Program represents an innovative way to support patients with RA when treated with abatacept IvI, generating measurable economic value for both rheumatology centres and INHS

Evaluation of Zirconia and High Performance Polymer Abutment Surface Roughness and Stress Concentration for Implant-Supported Fixed Dental Prostheses

Background: The High Performance Polymer is a based polymer biomaterial that was introduced as dental material to manufacture dentures superstructure and dental implants abutments. However, its surface characteristics and stress state still need to be properly described. The aim of this study was to compare the surface characteristics of a High Performance Polymer (Bio-HPP, Bredent, Senden, Germany) for computer-aided design and computer-aided manufacturing (CAD/CAM) milling and a Zirconia (Zirkonzahn, Steger, Ahrntal, Italy). Methods: The abutments surface roughness (Ra) was evaluated for each abutment material (N = 12) using a confocal laser microscope. Data were evaluated using One-Way ANOVA and Tukey tests (p < 0.05). In addition, a finite element analysis software was used to present stress measurement data as stress maps with 100 N loading. Results were generated according to Von-mises stress criteria and stress peaks were recorded from each structure. Results: Results showed a mean Ra of 0.221 ± 0.09 µm for Bio-HPP and 1.075 ± 0.24 µm for Zirconia. Both surface profiles presented a smooth characteristic regardless the measurement axis. The stress peaks from implant fixture and screw were not affected by the abutment material, however the high performance polymer showed the highest stress magnitude for the abutment region. Conclusions: Comparing the present results with the literature it is suggested that the CAD/CAM High Performance Polymer abutments present an adequate surface roughness with acceptable values of stress

Evaluation of Zirconia and High Performance Polymer Abutment Surface Roughness and Stress Concentration for Implant-Supported Fixed Dental Prostheses

Background: The High Performance Polymer is a based polymer biomaterial that was introduced as dental material to manufacture dentures superstructure and dental implants abutments. However, its surface characteristics and stress state still need to be properly described. The aim of this study was to compare the surface characteristics of a High Performance Polymer (Bio-HPP, Bredent, Senden, Germany) for computer-aided design and computer-aided manufacturing (CAD/CAM) milling and a Zirconia (Zirkonzahn, Steger, Ahrntal, Italy). Methods: The abutments surface roughness (Ra) was evaluated for each abutment material (N = 12) using a confocal laser microscope. Data were evaluated using One-Way ANOVA and Tukey tests (p < 0.05). In addition, a finite element analysis software was used to present stress measurement data as stress maps with 100 N loading. Results were generated according to Von-mises stress criteria and stress peaks were recorded from each structure. Results: Results showed a mean Ra of 0.221 ± 0.09 µm for Bio-HPP and 1.075 ± 0.24 µm for Zirconia. Both surface profiles presented a smooth characteristic regardless the measurement axis. The stress peaks from implant fixture and screw were not affected by the abutment material, however the high performance polymer showed the highest stress magnitude for the abutment region. Conclusions: Comparing the present results with the literature it is suggested that the CAD/CAM High Performance Polymer abutments present an adequate surface roughness with acceptable values of stress

Evaluation of Zirconia and High Performance Polymer Abutment Surface Roughness and Stress Concentration for Implant-Supported Fixed Dental Prostheses

Background: The High Performance Polymer is a based polymer biomaterial that was introduced as dental material to manufacture dentures superstructure and dental implants abutments. However, its surface characteristics and stress state still need to be properly described. The aim of this study was to compare the surface characteristics of a High Performance Polymer (Bio-HPP, Bredent, Senden, Germany) for computer-aided design and computer-aided manufacturing (CAD/CAM) milling and a Zirconia (Zirkonzahn, Steger, Ahrntal, Italy). Methods: The abutments surface roughness (Ra) was evaluated for each abutment material (N = 12) using a confocal laser microscope. Data were evaluated using One-Way ANOVA and Tukey tests (p &lt; 0.05). In addition, a finite element analysis software was used to present stress measurement data as stress maps with 100 N loading. Results were generated according to Von-mises stress criteria and stress peaks were recorded from each structure. Results: Results showed a mean Ra of 0.221 &plusmn; 0.09 &mu;m for Bio-HPP and 1.075 &plusmn; 0.24 &mu;m for Zirconia. Both surface profiles presented a smooth characteristic regardless the measurement axis. The stress peaks from implant fixture and screw were not affected by the abutment material, however the high performance polymer showed the highest stress magnitude for the abutment region. Conclusions: Comparing the present results with the literature it is suggested that the CAD/CAM High Performance Polymer abutments present an adequate surface roughness with acceptable values of stress

Toothbrushing wear resistance of stained cad/cam ceramics

Aim: To investigate the effect of toothbrushing on different stained Computerd Aided Design/Computer Aided Manufacturing CAD/CAM ceramics. Materials and Methods: Fifty specimens (high translucency zirconia, YZHT; zirconia-reinforced lithium silicate, ZLS; feldspathic, FDL; hybrid ceramic, HC; all from Vita Zahnfabrik) were divided into five groups according to their staining technique. ZLS allowed the composition of two groups: ZLS1 with crystallization and staining together; ZLS2, with the stain firing after the crystallization. YZHT received a stain firing after the sintering process, and FDL received stain firing directly. The HC was stained with acrylic stain-ing, and was light-cured on its surface. The specimens were brushed in total for 150,000 cycles at 2.45 N with 180 strokes/min. Surface measurements to obtain Rz were performed after 50,000, 100,000 and 150,000 cycles, with five evaluation lines (5 mm) per specimen orthogonal to the brushing direction, covering brushed and unbrushed areas. The wear was analyzed using two-way ANOVA and Tukey tests (α = 5%). Scanning electron microscopy (SEM) was performed to access the surface profile. The wear was affected by material (p < 0.001) and time (p = 0.139). Superior wear (µm) was observed for HC (6.6 ± 4.4; 6.8 ± 4.0; 9.2 ± 3.5) compared to ZLS2 (1.0 ± 0.3; 1.2 ± 2.2; 1.3 ± 0.3), YZHT (1.0 ± 0.1; 1.2 ± 0.3; 1.2 ± 0.3), ZLS1 (0.9 ± 0.1; 1.1 ± 0.5; 1.2 ± 0.3) and FDL (0.9 ± 0.1; 0.9 ± 0.1; 1.0 ± 0.2) after 5, 10 and 15 years of simulation, respectively. SEM showed different wear patters for HC with the removal of the glaze layer. HC showed a higher staining wear rate compared to the glass-based and polycrystalline ceramics after 15 years. The extrinsic characterization of feldspathic ceramic showed its superior longevity compared to the evaluated high-translucency zirconia, zir-conia-reinforced lithium silicate, and hybrid ceramic