7 research outputs found
Countryside Survey 2000. Module 2: survey of freshwater habitats. R&D Progress Report E1/038/5 for the period 1st February 1999 to 31st March 1999
Effect of allergen challenge on airway responsiveness to histamine and sodium metabisulphite in mild asthma.
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Relative muon content of UHE showers associated with Hercules X-1
A further analysis is presented of the muon content associated with the July, 1986 UHE observation of the Hercules X-1 system, previously reported by the CYGNUS collaboration. The probability for observing comparable muon content in a set of background'' showers similar to those of the Hercules burst is given. 3 refs., 2 tabs
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A low threshold EAS (extensive-air-shower) array for gamma-ray astronomy at Los Alamos
A new type of extensive-air-shower (EAS) array is described that achieves a low energy threshold, large area, high duty factor and large muon coverage. By placing a regularly-spaced grid of phototubes just below the surface of a shallow pond, the Cherenkov light of particles in an air shower striking the water can be detected, resulting in a primary energy threshold of less than 1 TeV. This highly sensitive array can thus be used to span the gap of information between the existing air Cherenkov techniques at 1 TeV and the existing EAS arrays at 100 TeV. 5 refs., 3 figs
A common haplotype lowers PU.1 expression in myeloid cells and delays onset of Alzheimer's disease
A genome-wide survival analysis of 14,406 Alzheimer's disease (AD) cases and 25,849 controls identified eight previously reported AD risk loci and 14 novel loci associated with age at onset. Linkage disequilibrium score regression of 220 cell types implicated the regulation of myeloid gene expression in AD risk. The minor allele of rs1057233 (G), within the previously reported CELF1 AD risk locus, showed association with delayed AD onset and lower expression of SPI1 in monocytes and macrophages. SPI1 encodes PU.1, a transcription factor critical for myeloid cell development and function. AD heritability was enriched within the PU.1 cistrome, implicating a myeloid PU.1 target gene network in AD. Finally, experimentally altered PU.1 levels affected the expression of mouse orthologs of many AD risk genes and the phagocytic activity of mouse microglial cells. Our results suggest that lower SPI1 expression reduces AD risk by regulating myeloid gene expression and cell function