A multi-technique investigation of N2 doubly excited states

In this work we present a multi-technique investigation of the formation and decay of neutral doubly excited states of N-2. These states, lying in the energy region 20-35 eV, have been studied by electron impact and photoionisation experiments

In patients with newly-diagnosed type 2 diabetes beta cell function is an independent predictor of glucose control evolution over 18 months

Background and aims: We asked the question whether the metabolic phenotype at baseline and/or a number of type 2 diabetes mellitus (T2DM) risk genes may predict the evolution of glucose control (GC) within the first 18 months after diagnosis of the disease. Materials and methods: 593 GAD-antibodies negative patients with newly diagnosed T2DM (age: 59\ub10.4 yrs; BMI: 30.0\ub10.2 kg/m2) were studied with: 1. Prolonged (5-hours) frequently sampled OGTT to assess beta cell function(BCF) by state of art mathematical modelling of glucose and C-peptide; 2. Standard euglycemic insulin clamp to assess insulin sensitivity (SI); 3. Genotyping the common T2DM risk variants of the following genes: ADAMTS9, CDKAL1, FTO, G6PC2, GCK, GCKR, GNPDA2, HHEX, HNF1B, IGF2BP2, IRS1, JAZF1, KCNJ11, MTNR1B, NOTCH2, PPARG, SCL30A8, TCFL2, THADA,TMEM18, TSPAN and WFS1. GC evolution was defined as the difference between HbA1c at diagnosis (7.0\ub10.1%) and HbA1c at 18 months (6.5\ub10.1%). Results: 141 patients were lost to follow-up, thereby leaving 452 patients for evaluation. In all multivariate regression models, basal HbA1c (standardizedbeta [stBETA]: 0.92, p<0.0001) was the strongest positive predictor of favourable GC evolution (i.e. the higher HbA1c at diagnosis, the greater its fall within 18 months). No role for T2DM risk gene variants, either as a single SNP or as a genetic score derived from all SNPs, could be detected. BCF(stBETA: 0.26) and eGFR (stBETA: 0.08), but not age nor BMI nor SI nor pharmacological therapy, were positive independent predictors of favourable GC evolution (p<0.001 e p<0.01, respectively). Conclusion: Thus, better BCF at diagnosis, but not SI nor the T2DM genotype assessed in this study, is an independent predictor and a putative determinantof more desirable short-term (18 months) GC evolution

Improved Quality of Life after bariatric surgery in morbidly obese patients. Interdisciplinary group of bariatric surgery of Verona (G.I.C.O.V.).

Background. Our aim was to evaluate the changes of health-related Quality of Life (HR-QoL) after bariatric surgery. Patients and methods. 110 patients, who underwent laparoscopic bariatric surgery (N=34 gastric banding; N= 69 Roux-en-Y gastric bypass, N=7 sleeve gastrectomy), were evaluated before surgery and after an average of 36\ub113 months with SF-36 Health Survey. Results. Mean preoperative age and body mass index (BMI) were 43\ub112 years and 45\ub17 kg/m2 respectively. At follow-up, mean BMI was 33\ub16 kg/m2. A significant improvement was observed for all dimensions of SF-36, except for General and Mental Health dimension. Satisfaction was greater in patients with the higher reduction in weight. Only the PF (Physical Functioning) domain (F=6,349, p=0.01) resulted a significant predictor of the weight lost after surgery independently of age, sex and type of surgery. Conclusions. We confirm a beneficial effect of bariatric surgery on HR-QoL. Moreover, we found that PF domain of SF-36 is a significant predictor of weight loss

Improved Quality of Life after bariatric surgery in morbidly obese patients. Interdisciplinary group of bariatric surgery of Verona (G.I.C.O.V.).

Background. Our aim was to evaluate the changes of health-related Quality of Life (HR-QoL) after bariatric surgery. Patients and methods. 110 patients, who underwent laparoscopic bariatric surgery (N=34 gastric banding; N= 69 Roux-en-Y gastric bypass, N=7 sleeve gastrectomy), were evaluated before surgery and after an average of 36\ub113 months with SF-36 Health Survey. Results. Mean preoperative age and body mass index (BMI) were 43\ub112 years and 45\ub17 kg/m2 respectively. At follow-up, mean BMI was 33\ub16 kg/m2. A significant improvement was observed for all dimensions of SF-36, except for General and Mental Health dimension. Satisfaction was greater in patients with the higher reduction in weight. Only the PF (Physical Functioning) domain (F=6,349, p=0.01) resulted a significant predictor of the weight lost after surgery independently of age, sex and type of surgery. Conclusions. We confirm a beneficial effect of bariatric surgery on HR-QoL. Moreover, we found that PF domain of SF-36 is a significant predictor of weight loss