40 research outputs found
PCT, spin and statistics, and analytic wave front set
A new, more general derivation of the spin-statistics and PCT theorems is
presented. It uses the notion of the analytic wave front set of
(ultra)distributions and, in contrast to the usual approach, covers nonlocal
quantum fields. The fields are defined as generalized functions with test
functions of compact support in momentum space. The vacuum expectation values
are thereby admitted to be arbitrarily singular in their space-time dependence.
The local commutativity condition is replaced by an asymptotic commutativity
condition, which develops generalizations of the microcausality axiom
previously proposed.Comment: LaTeX, 23 pages, no figures. This version is identical to the
original published paper, but with corrected typos and slight improvements in
the exposition. The proof of Theorem 5 stated in the paper has been published
in J. Math. Phys. 45 (2004) 1944-195
Towards a Generalized Distribution Formalism for Gauge Quantum Fields
We prove that the distributions defined on the Gelfand-Shilov spaces, and
hence more singular than hyperfunctions, retain the angular localizability
property. Specifically, they have uniquely determined support cones. This
result enables one to develop a distribution-theoretic techniques suitable for
the consistent treatment of quantum fields with arbitrarily singular
ultraviolet and infrared behavior. The proofs covering the most general case
are based on the use of the theory of plurisubharmonic functions and
Hormander's estimates.Comment: 12 p., Department of Theoretical Physics, P.N.Lebedev Physical
Institute, Leninsky prosp. 53, Moscow 117924, Russi
Applying REWIND cardiovascular disease criteria to SUSTAIN 6 and PIONEER 6: An exploratory analysis of cardiovascular outcomes with semaglutide
In the REWIND trial, dulaglutide reduced cardiovascular (CV) risk versus placebo in patients with type 2 diabetes in both the “established CV disease” (CVD) and “CV risk factor” subgroups. The SUSTAIN 6 and PIONEER 6 trials of semaglutide used different criteria for established CVD from those used in REWIND. The present post hoc analysis assessed the effect of semaglutide on major adverse CV events (MACE) in a pooled population of SUSTAIN 6 and PIONEER 6 patients, re-categorized into CV risk subgroups using the REWIND CVD criteria. In the pooled analysis (n = 6480), a lower percentage of patients were in the established CVD subgroup, when using the REWIND CVD criteria, compared with the original trial CVD criteria (66.5% vs. 83.8%, respectively). After re-categorization, the risk of MACE was significantly lower with semaglutide versus placebo in the established CVD subgroup (hazard ratio [HR] 0.74, 95% confidence interval [CI] 0.59, 0.92) and nonsignificantly lower in the CV risk factor subgroup (HR 0.84, 95% CI 0.55, 1.28) (P-interaction = 0.60). These results suggest that the CV effects of semaglutide may extend to patients with type 2 diabetes across the CV risk continuum