(E)-2-Methyl-6-[(1-phenyl-1H-pyrazol-4-yl)methyl­idene]cyclo­hexa­none

The asymmetric unit of the title compound, C17H18N2O, contains two independent mol­ecules. In both, the cyclo­hexane ring adopts a flattened chair conformation, and the 3- and 4-methyl­ene C atoms as well as the methyl C atoms are disordered over two positions, the occupancy of the major component being 68 (1)% in one mol­ecule and 64 (1)% in the other. The phenyl and pyrazole rings in both mol­ecules are approximately coplanar, the r.m.s. deviations being 0.048 and 0.015 Å, respectively. Weak inter­molecular C—H⋯O hydrogen bonding is present in the crystal structure

4-{(4Z)-4-[(2Z)-3-(4-Fluoro­anilino)-1-hy­droxy­but-2-en-1-yl­idene]-3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl}­benzene­sulfonamide

In the title compound, C20H19FN4O4S, the pyrazole and benzene­sulfonamide rings are coplanar [dihedral angle = 5.02 (15)°] but this planarity does not extend over the entire mol­ecule, the dihedral angle between the terminal six-membered rings being 33.24 (14)°. Intra­molecular hy­droxy–hy­droxy O—H⋯O and amine–hy­droxy N—H⋯O hydrogen bonds, as a well as a tight C—H⋯O(carbon­yl) inter­action, lead to a sequence of three fused S(6) rings. Supra­molecular chains along the a axis feature in the crystal packing; these chains are stabilized by amine–sulfonamide N—H⋯O and amine–pyrazole N—H⋯N hydrogen bonds

2-Amino-4-(3,4-dimeth­oxy­phen­yl)-5,6-dihydro­benzo[h]quinoline-3-carbo­nitrile–3-amino-1-(3,4-dimeth­oxy­phen­yl)-9,10-dihydro­phenanthrene-2,4-dicarbonitrile (1/19)

The asymmetric unit of the 1:19 title co-crystal of 2-amino-4-(3,4-dimeth­oxy­phen­yl)-5,6-dihydro­benzo[h]quinoline-3-carbo­nitrile and 3-amino-1-(3,4-dimeth­oxy­phen­yl)-9,10-dihydro­phenanthrene-2,4-dicarbonitrile, 0.05C22H19N3O2·0.95C24H19N3O2, has the atoms of the fused-ring system and those of the amino, cyano and dimeth­oxy­phenyl substitutents overlapped. The fused-ring system is buckled owing to the ethyl­ene linkage in the central ring with the two flanking aromatic rings being twisted by 31.9 (1)°. The ring of the dimeth­oxy­phenyl substituent is twisted by 72.4 (1)° relative to the amino- and cyano-bearing aromatic ring. In the crystal, mol­ecules are linked by duplex amine N—H⋯O(meth­oxy) hydrogen bonds in a cyclic association [graph-set R 2 2(7)], generating a helical chain structure extending along [201]

(2Z)-3-(4-Fluoro­anilino)-1-(5-hy­droxy-3-methyl-1-phenyl-1H-pyrazol-4-yl)but-2-en-1-one

The central carbonyl group in the title compound, C20H18FN3O2, forms amine–hy­droxy N—H⋯O and hy­droxy–hy­droxy O—H⋯O hydrogen bonds, leading to two S(6) rings. The N-bound phenyl ring is coplanar with the five-membered ring to which it is attached [dihedral angle = 6.27 (10)°], but an overall twist in the mol­ecule is evident, the dihedral angle between the terminal phenyl and benzene rings being 27.30 (10)°. Mol­ecules aggregate into a three-dimensional architecture via C—H⋯F, C—H⋯O and C—H⋯π inter­actions

Synthesis of Substituted Thioureas and Their Sulfur Heterocyclic Systems of p

A series of new N,N′-substituted thioureas (2, 6, and 8) and their sulfur heterocycles as thiobarbituric acids (3, 4, and 7), 2-thioxothiazoliodin-4-one (10), thiazolidin-4-one (11), 1,2,4-triazol-5-thione (14), and 1,3,4-thiadiazole (15) of p-Amino salicylic acid (PAS) have been synthesized from treatment with dithiocarbazinate (1, 5 and 12) followed by heterocyclization with dimethyl malonate, chloroacetic acid, and/or trifluoroacetic anhydride. The structures of the newly synthesized compounds were substantiated with IR, H1, and C13 NMR spectral data and elementary microanalyses. The in vitro antitubercular activity of synthesized compounds against M. tuberculosis strain H37Rv showed moderate-to-good activity

4-(2,7-Dimethyl-4-oxo-1,3-thia­zolo[4,5-d]pyridazin-5-yl)benzene­sulfonamide

The thia­zole–pyridazine fused-ring system of the title compound, C13H12N4O3S2, is approximately planar (r.m.s. deviation = 0.037 Å); the benzene ring connected to the fused-ring system through the N atom is twisted by 39.3 (1)°. The amine group uses an H atom to form a hydrogen bond to the ketonic O atom of an inversion-related mol­ecule to generate a dimer; adjacent dimers are linked by an N—H⋯O hydrogen bond to form a linear chain

4-(3-Methyl-5-phenyl-1H-pyrazol-1-yl)benzene­sulfonamide

With respect to the planar five-membered ring of the title compound, C16H15N3O2S, the phenyl ring is aligned at 47.0 (1)° and the phenyl­ene ring at 37.6 (1)°. The amino group has the N atom in a pyramidal geometry; the group is a hydrogen-bond donor to the sulfonyl O atom of one mol­ecule and to the pyrazole N atom of another mol­ecule, resulting in the formation of a layer parallel to the bc plane

(E,E)-4-{4-[3-(4-Chloro­anilino)-1-hydroxy­but-2-enyl­idene]-3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl}­benzene­sulfonamide

The mol­ecule of the title compound, C20H19ClN4O4S, features a central pyrazole ring that possesses a benzene substituent, as well as a conjugated =C—C=C—Cmeth­yl substituent. The benzene ring is slightly twisted [dihedral angle = 7.7 (2)°] with respect to the five-membered ring; the mean plane of the zigzag =C—C=C—C fragment [torsion angle = 178.0 (4)°] is also slightly twisted [dihedral angle = 10.6 (4)°]. The amine and hy­droxy groups form intra­molecular hydrogen bonds. The amide group uses one of its H atoms to form a hydrogen bond to the sulfamyl O atom of an inversion-related mol­ecule. Adjacent dimers are further linked by an N—Hamido⋯Npyrazole hydrogen bond to generate a linear chain. The crystal studied is a nonmerohedral twin with a minor twin component of 25.6 (2)%

4-[5-(Furan-2-yl)-3-trifluoro­methyl-1H-pyrazol-1-yl]benzene­sulfonamide

In the title compound, C14H10F3N3O3S, there are significant twists in the mol­ecule, as seen in the values of the dihedral angles between the pyrazole ring and each of the furan [31.1 (2)°] and benzene rings [55.58 (10)°]. The amino N atom occupies a position almost normal to the benzene ring [N—S—Car—Car (ar = aromatic) torsion angle = 83.70 (19)°]. One amino H atom forms a hydrogen bond to the tricoordinate pyrazole N atom and the other inter­acts with a sulfonamide O atom, forming a supra­molecular chain along [010]. The chains are consolidated into a supra­molecular layers via C—H⋯O inter­actions involving the second sulfonamide O atom; layers stack along [10-1]. The furan ring was found to be disordered over two diagonally opposite orientations of equal occupancy

Ethyl N-[4-(3-methyl-4,5-dihydro­benzo[g]indazol-1-yl)phenyl­sulfon­yl]thio­carbam­ate ethanol monosolvate

The title compound, C21H20N3O3S2·CH3CH2OH, comprises two independent organic mol­ecules and two ethanol solvent mol­ecules. The mol­ecules are related by pseudo-mirror symmetry. In both mol­ecules, the N-bound benzene ring is twisted out of the plane of the pyrazole ring [the dihedral angles are 51.4 (3) and 44.1 (3)°, respectively]. Similarly, the benzene ring of the 1,2-dihydro­naphthalene residue is inclined with respect to the five-membered ring [dihedral angles 18.3 (3) and 22.2 (3)°]. Overall, each mol­ecule has a flattened U shape. Dimeric aggregates mediated by O—H⋯N(pyrazole) and amide-N—H⋯O hydrogen bonds feature in the crystal packing, whereby the ethanol mol­ecules link the independent organic mol­ecules, leading to four-mol­ecule aggregates