2 research outputs found
Comparison of Epinephrine to Salbutamol in Acute Bronchiolitis
Objective: An appropriate treatment of acute viral bronchiolitis can
reduce the symptoms, hospitalization duration and exorbitant costs
which is imposed on the families and insurance organizations. This
study was conducted to determine the efficacy of epinephrine in
comparison with salbutamol in the treatment of the disease. Methods:
Forty infants aged one month to 2 years with acute bronchiolitis in
Amin and Al-Zahra hospitals, during 2008, were enrolled in this study.
The participants were randomized in two treatment groups to receive
epinephrine 0.1 ml/kg or salbutamol 0.15 mg/kg. Three doses of each
medication were prescribed at intervals of 20 minutes and continued
every 10 minutes after the third dose. The patients in both groups were
monitored and rated by RDAI, number of the hospitalized days in the
hospital, level of oxygen saturation and vital signs. Findings: Mean
hospitalization duration was 3.3±1.1 and 3±0.9 in the
patients receiving salbutamol and epinephrine, respectively (P=0.03).
There was a significant difference in assessing RDAI index between the
two groups (P=0.03). There were no differences in SPO2, PR, or RR
variables in the studied intervals in both groups (P >0.05).
Conclusion: Regarding the effect of epinephrine on reduction of
hospitalization duration and the RDAI index in patients with acute
bronchiolitis, it seems that using epinephrine instead of salbutamol
could be more effective in the management of the disease