SPINAL EPIDURAL HAEMATOMA WITHOUT SIGNIFICANT TRAUMA IN A CHILD

Spinal epidural haematoma without significant precedent trauma is an emergency medical condition, which is rarely encountered in paediatrics. The diagnosis is made by clinical examination and imaging. Treatment is generally surgical. In this paper, we present the clinical picture and treatment of spinal epidural haematoma in an eleven-year-old previously healthy boy, who complained of sudden pain in the right shoulder blade area. Clinically, we suspected spinal pathology, which was eventually proven by magnetic resonance imaging. After surgical evacuation of the haematoma, the boy made a complete recovery

SPINALNI EPIDURALNI HEMATOM BREZ POMEMBNE POŠKODBE PRI OTROKU

Spinalni epiduralni hematom brez pomembne predhodne poškodbe je nujno stanje, s katerim se v pediatriji srečamo zelo redko. Diagnozo postavimo s kliničnim pregledom in slikovno preiskavo. Zdravljenje je večinoma kirurško. V prispevku predstavljamo spinalni epiduralni hematom pri enajstletnem, do tedaj zdravem dečku, ki je nenadoma začutil bolečino v predelu desne lopatice. Po kliničnem pregledu smo sum na patološko dogajanje v predelu hrbtenice potrdili z magnetnoresonančnim slikanjem. Po kirurški evakuaciji hematoma je deček popolnoma okreval

The influence of folate pathway polymorphisms on high-dose methotrexaterelated toxicity and survival in children with non-Hodgkin malignant lymphoma

Background. We evaluated the influence of folate pathway polymorphisms on high-dose methotrexate (HD-MTX) related toxicity in paediatric patients with T-cell non-Hodgkin lymphoma (NHL). Patients and methods. In total, 30 NHL patients were genotyped for selected folate pathway polymorphisms

Association between SLC19A1 gene polymorphism and high dose methotrexate toxicity in childhood acute lymphoblastic leukaemia and non Hodgkin malignant lymphoma: introducing a haplotype based approach

We investigated the clinical relevance of SLC 19A1 genetic variability for high dose methotrexate (HD-MTX) related toxicities in children and adolescents with acute lymphoblastic leukaemia (ALL) and non Hodgkin malignant lymphoma (NHML)

HEALTH-RELATED QUALITY OF LIFE IN PATIENTS WITH HAEMOPHILIA AND ITS ASSOCIATION WITH DEPRESSIVE SYMPTOMS: A STUDY IN CROATIA AND SLOVENIA

Background: There are only a few studies in patients with haemophilia (PWH) that examined both quality of life and depressive symptoms, with only few studies examining their association. Aim of this study was to examine the association between depressive symptoms and health-related quality of life (HRQoL) in PWH from Croatia and Slovenia. Subjects and methods: A total of 112 adult PWH on prophylactic (73%) or on-demand (27%) treatment were included in the study (median age 46 years, range 18-73 years). Depressive symptoms were assessed with BDI-II, HRQoL with SF-36v2, demographic and socioeconomic data were collected using a questionnaire, and clinical data were obtained from medical records. Results: All HRQoL scores were significantly negatively correlated with BDI-II in the -0.42 to -0.70 range (all p<0.05). Sociodemographic and clinical variables explained 28-51% of HRQoL variance scores. Depressive symptoms explained additional variance for six HRQoL domain scores, with incremental variance being larger for mental domain scores (ranging between 10- 27%), and for Mental Component Summary score (26%). Conclusions: This study’s findings support that having depressive symptoms is associated with HRQoL of PWH, more so in the mental health than in the physical health domains

Diagnostic accuracy of haemophilia early arthropathy detection with ultrasound (HEAD-US): a comparative magnetic resonance imaging (MRI) study

Repeated haemarthroses affect approximately 90% of patients with severe haemophilia and lead to progressive arthropathy, which is the main cause of morbidity in these patients. Diagnostic imaging can detect even subclinical arthropathy changes and may impact prophylactic treatment. Magnetic resonance imagining (MRI) is generally the gold standard tool for precise evaluation of joints, but it is not easily feasible in regular follow-up of patients with haemophilia. The development of the standardized ultrasound (US) protocol for detection of early changes in haemophilic arthropathy (HEAD-US) opened new perspectives in the use of US in management of these patients. The HEAD-US protocol enables quick evaluation of the six mostly affected joints in a single study. The aim of this prospective study was to determine the diagnostic accuracy of the HEAD-US protocol for the detection and quantification of haemophilic arthropathy in comparison to the MRI