Possible beneficial effects of amlodipine, lisinopril, and their Combination on lipid profile in hypertensive patients

It is well known that monotherapy does not provide therapeutic response in all hypertensive. Somepatients show an excellent response, while in others there is a poor response. Combinationantihypertensive therapy is administered when blood pressure is inadequately controlled bymonotherapy to achieve a balanced and additive antihypertensive effect with minimum adverse effects.Both angiotensin converting enzyme (ACE) inhibitors and dihydropyridine type of calcium antagonistsare well established and widely used in monotherapy. An understanding of differences in themechanism of action of these agents allows a logical approach for the use of these agents as acombination therapy. This study was designed to evaluate the possible beneficial effects of long actingcalcium channel blocker, amlodipine and the long acting Angiotensin converting enzyme (ACE)inhibitor, lisinopril given either alone or in combination in patients with essential hypertension on lipidprofile (LDL-C and HDL-C) and on other parameters using a randomized double blind, crossoverstudy. The study includes 150 patients with systolic blood pressure (SBP)&gt;140 mmHg and diastolicblood pressure (DBP) &gt;90 mmHg received amlodipine 5 mg, lisinopril 5 mg and their combinationprior randomization schedule. Systolic, diastolic blood pressure and pulse rate were recorded at weeklyintervals while, serum levels of urea, creatinine, LDL-C and HDL-C where recorded at monthlyintervals, the duration of this study was 3 months. Results were obtained using paired students t-test,differences were considered significant with (p&lt;0.05).A significant decline in SBP and DBP in all treatment groups (p&lt;0.05) was recorded, the reductiontend to be more pronounced in the combination group. Moreover, there was a significant effect ofcombination on the heart rate, serum level of urea and creatinine, beside that, the level of HDL wassignificantly elevated with amlodipine and combination. We concluded that combination had additionalblood pressure lowering effect when compared either with amlodipine or lisinopril alone, in addition tothe greater effect on lipid profile which demonstrated that this combination is potentialantiatherosclerotic agent.</jats:p

Single Dose Antibiotic Prophylaxis in Outpatient Oral Surgery Comparative Study

         It is clear that correct application of antibiotic prophylaxis can reduce the incidence of infection  resulting from the bacterial  inoculation in a variety of clinical situations; it cannot   prevent  all  infections  any  more  than it  can   eliminate  all  established infections. Optimum  antibiotic   prophylaxis  depends on:  rational  selection  of the drug(s),  adequate  concentrations  of the  drug  in  the  tissues that  are at risk, and attention to  timing  of  administration.  Moreover,  the  risk  of  infection  in  some situations  does not outweigh  the risks which  attend the administration of even the safest antibiotic drug. The aim of this study was to compare between 2 prophylactic protocols  in  out  patients  undergoing  oral  surgical  procedures.  Thirty   patients, selected from the attendants of oral surgery clinic in Al-Karamah Dental Center, were subjected to different oral surgical procedures under local  anesthesia. These patients were given single dose antibiotic  prophylaxis in 2 groups; 1st group were 15 patients given 1 million i.u. of procaine  penicillin  I.M. 30 minutes  before oral  surgery, 2nd group were 15 patients given 600mg clindamycin orally 1 hours before oral surgery. The  maximum  time  for  all  procedures  was 2 hours. There  was  no  difference between  procaine  penicillin  (1 million i.u.), and  clindamycin (600mg),  regimens concerning post operative infection in out patient’s oral surgical procedures. Key words: Antibiotic prophylaxis, outpatient oral surger

Single Dose Antibiotic Prophylaxis in Outpatient Oral Surgery Comparative Study

         It is clear that correct application of antibiotic prophylaxis can reduce the incidence of infection  resulting from the bacterial  inoculation in a variety of clinical situations; it cannot   prevent  all  infections  any  more  than it  can   eliminate  all  established infections. Optimum  antibiotic   prophylaxis  depends on:  rational  selection  of the drug(s),  adequate  concentrations  of the  drug  in  the  tissues that  are at risk, and attention to  timing  of  administration.  Moreover,  the  risk  of  infection  in  some situations  does not outweigh  the risks which  attend the administration of even the safest antibiotic drug. The aim of this study was to compare between 2 prophylactic protocols  in  out  patients  undergoing  oral  surgical  procedures.  Thirty   patients, selected from the attendants of oral surgery clinic in Al-Karamah Dental Center, were subjected to different oral surgical procedures under local  anesthesia. These patients were given single dose antibiotic  prophylaxis in 2 groups; 1st group were 15 patients given 1 million i.u. of procaine  penicillin  I.M. 30 minutes  before oral  surgery, 2nd group were 15 patients given 600mg clindamycin orally 1 hours before oral surgery. The  maximum  time  for  all  procedures  was 2 hours. There  was  no  difference between  procaine  penicillin  (1 million i.u.), and  clindamycin (600mg),  regimens concerning post operative infection in out patient’s oral surgical procedures.&#x0D; Key words: Antibiotic prophylaxis, outpatient oral surgery</jats:p