A seismological and engineering perspective on the 2016 Central Italy earthquakes

The strong earthquake (M 6.0-6.2) that hit the central Apennines on August 24, 2016, occurred in one of the most seismically active areas in Italy. Field surveys indicated severe damage in the epicentral area where, in addition to the loss of human life, widespread destruction of cultural heritage and of critical buildings occurred. Using the neo-deterministic seismic hazard assessment (NDSHA), we apply the maximum deterministic seismic input (MDSI) procedure at two of the most relevant sites in the epicentral area, comparing the results with the current Italian building code. After performing an expeditious engineering analysis, we interpret as a possible cause of the reported damages the high seismic vulnerability of the built environment, combined with the source and site effects characterising the seismic input. Therefore, it is important to design and retrofit with appropriate spectral acceleration levels compatible with the possible future scenarios, like the ones provided by MDSI

Deep structure of the Alborz Mountains by joint inversion of P receiver functions and dispersion curves

The Alborz Mountains represent a tectonically and seismically active convergent boundary in the Arabia \u2013 Eurasia collision zone, in western Asia. The orogenic belt has undergone a long-lasted tectono-magmatic history since the Cretaceous. The relationship between shallow and deep structures in this complex tectonic domain is not straightforward. We present a 2D velocity model constructed by the assemblage of 1D shear wave velocity (Vs) models from 26 seismic stations, mainly distributed along the southern flank of the Alborz Mountains. The shear wave velocity structure has been estimated beneath each station using joint inversion of P-waves receiver functions and Rayleigh wave dispersion curves. A substantiation of the Vs inversion results sits on the modeling of Bouguer gravity anomaly data. Our velocity and density models show low velocity/density anomalies in uppermost mantle of western and central Alborz at a depth range of 3c50\u2013100 km. In deeper parts of the up- permost mantle (depth range of 100\u2013150 km), a high velocity/density anomaly is located beneath most of the Mountain range. The spatial pattern of these low and high velocity/density structures in the upper mantle is interpreted as the result of post collisional delamination of lower part of the western and central Alborz lithosphere

Transition from continental collision to tectonic escape? A geophysical perspective on lateral expansion of the northern Tibetan Plateau

A number of tectonic models have been proposed for the Tibetan Plateau, which origin, however, remains poorly understood. In this study, investigations of the shear wave velocity (Vs) and density (ρ) structures of the crust and upper mantle evidenced three remarkable features: (1) There are variations in Vs and ρ of the metasomatic mantle wedge in the hanging wall of the subduction beneath different tectonic blocks of Tibet, which may be inferred as related to the dehydration of the downgoing slab. (2) Sections depicting gravitational potential energy suggest that the subducted lithosphere is less dense than the ambient rocks, and thus, being buoyant, it cannot be driven by gravitational slab pull. The subduction process can be inferred by the faster SW-ward motion of Eurasia relative to India as indicated by the plate motions relative to the mantle. An opposite NE-ward mantle flow can be inferred beneath the Himalaya system, deviating E and SE-ward toward China along the tectonic equator. (3) The variation in the thickness of the metasomatic mantle wedge suggests that the leading edge of the subducting Indian slab reaches the Bangoin-Nujiang suture (BNS), and the metasomatic mantle wedge overlaps with a region with poor Sn-wave propagation in north Tibet. The metasomatic layer, north of the BNS, deforms in the E-W direction to accommodate lithosphere shortening in south Tibet

Mirna Expression Profiles Identify Drivers in Colorectal and Pancreatic Cancers

Altered expression of microRNAs (miRNAs) hallmarks many cancer types. The study of the associations of miRNA expression profile and cancer phenotype could help identify the links between deregulation of miRNA expression and oncogenic pathways.Expression profiling of 866 human miRNAs in 19 colorectal and 17 pancreatic cancers and in matched adjacent normal tissues was investigated. Classical paired t-test and random forest analyses were applied to identify miRNAs associated with tissue-specific tumors. Network analysis based on a computational approach to mine associations between cancer types and miRNAs was performed. in pancreatic cancers.MiRNA expression profiles may identify cancer-specific signatures and potentially useful biomarkers for the diagnosis of tissue specific cancers. miRNA-network analysis help identify altered miRNA regulatory networks that could play a role in tumor pathogenesis

Erratum to: Seismic waves in 3-D: from mantle asymmetries to reliable seismic hazard assessment

Acknowledgments This paper is strongly relying upon the work of many colleagues and collaborators to whom we are greatly thankful, in particular: Carlo Doglioni, Gillian Foulger, Vahid Gholami, Hossein Hamzehloo, Volodya Kossobokov, Cristina La Mura, Anatoly Levshin, Andrea Magrin, Antonella Peresan, Federica Riguzzi, Franco Vaccari, Peter Varga, Tatiana Yanovskaya. Financial support from PRIN 2010-2011 and RITMARE projects, funded by Italian Ministry of University and Research, is gratefully acknowledged. In addition, Fig. 3 should be updated by new one as below

Complementary feeding in preterm infants: a position paper by Italian neonatal, paediatric and paediatric gastroenterology joint societies

Nutrition in the first 1000 days of life is essential to ensure appropriate growth rates, prevent adverse short- and long-term outcomes, and allow physiologic neurocognitive development. Appropriate management of early nutritional needs is particularly crucial for preterm infants. Although the impact of early nutrition on health outcomes in preterm infants is well established, evidence-based recommendations on complementary feeding for preterm neonates and especially extremely low birth weight and extremely low gestational age neonates are still lacking. In the present position paper we performed a narrative review to summarize current evidence regarding complementary feeding in preterm neonates and draw recommendation shared by joint societies (SIP, SIN and SIGENP) for paediatricians, healthcare providers and families with the final aim to reduce the variability of attitude and timing among professionals