LC Filter Design for On-grid and Off-grid Distributed Generating Units

This paper deals with the design procedure of an LC-based output filter for three-phase inverters to be used in both off-grid and on-grid scenarios. The aim of this procedure is to provide guidelines and component selection criteria for reducing the inverter output switching ripple in order to limit the interaction with the control algorithm and to increase the filter stability. A suitable combination of resistive and reactive components is used to realize the complete filter structure. The proposed procedure is applied to the design of the output power filter for a 40-kVA three-phase inverter

Pathology reporting in neuroendocrine neoplasms of the digestive system: everything you always wanted to know but were too afraid to ask

During the 5th NIKE (Neuroendocrine tumors Innovation in Knowledge and Education) meeting, held in Naples, Italy, in May 2019, discussions centered on the understanding of pathology reports of gastroenetropancreactic neuroendocrine neoplasms. In particular, the main problem concerned the difficulty that clinicians experience in extrapolating relevant information from neuroendocrine tumor pathology reports. During the meeting, participants were asked to identify and rate issues which they have encountered, for which the input of an expert pathologist would have been appreciated. This article is a collection of the most rated questions and relative answers, focusing on three main topics: 1) morphology and classification; 2) Ki67 and grading; 3) immunohistochemistry. Patient management should be based on multidisciplinary decisions, taking into account clinical and pathology-related features with clear comprehension between all health care professionals. Indeed, pathologists require clinical details and laboratory findings when relevant, while clinicians require concise and standardized reports. In keeping with this last statement, the minimum requirements in pathology datasets are provided in this paper and should be a baseline for all neuroendocrine tumor professionals

Commentary: Case Report: Abdominal Lymph Node Metastases of Parathyroid Carcinoma: Diagnostic Workup, Molecular Diagnosis, and Clinical Management

In the issue of March 2021, Lenschow et al. reported the case of a 46-year-old woman with recurrent, programmed death-ligand-1 (PD-L1) negative, tumor mutational burden (TMB)-high parathyroid carcinoma (PC), who showed stable disease as her best response on imaging, and a three-fold drop in PTH after treatment with intravenous pembrolizumab. Given the remarkable results obtained by Lenschow et al. with the anti-PD-1 agent pembrolizumab in the above-mentioned case, we performed an extensive search for possible further relevant data sources, including a) full published articles in international online databases (PubMed, Web of Science, Scopus, and Embase); b) preliminary reports in selected international meeting abstract repositories (American Society of Clinical Oncology, ASCO; European Neuroendocrine Tumor Society, ENET; European Society for Medical Oncology, ESMO); c) registered clinical trials in the U.S. National Institutes of Health registry of clinical trials (http://clinicaltrials.gov) and in any primary register of the WHO International Clinical Trials Registry Platform (ICTRP)

Single-phase inverter for grid-connected and intentional islanding operations in electric utility systems

Small distributed generation units are usually connected to the main electric grid through single-phase voltage source inverters. Grid operating conditions such as voltage and frequency are not constant and can fluctuate within the range values established by international standards. Furthermore, the requirements in terms of power factor correction, total harmonic distortion, and reliability are getting tighter day by day. As a result, the implementation of reliable and efficient control algorithms, which are able to adjust their control parameters in response to changeable grid operating conditions, is essential. This paper investigates the configuration topology and control algorithm of a single-phase inverter with the purpose of achieving high performance in terms of efficiency as well as total harmonic distortion of the output current. Accordingly, a Second Order Generalized Integrator with a suitable Phase Locked Loop (SOGI-PLL) is the basis of the proposed current and voltage regulation. Some practical issues related to the control algorithm are addressed, and a solution for the control architecture is proposed, based on resonant controllers that are continuously tuned on the basis of the actual grid frequency. Further, intentional islanding operation is investigated and a possible procedure for switching from grid-tied to islanding operation and vice-versa is proposed