Development of an Indoor Environmental Quality Assessment Tool for the Rating of Offices in Real Working Conditions

The Indoor Environmental Quality (IEQ) refers to the quality of indoor spaces in relation to the health and well-being of users. IEQ is a holistic concept considering various components of the overall indoor comfort: thermo-hygrometric, lighting, air quality and acoustics. Each component is described through specific performance indicators and benchmarks. The quality of the built environment is assessed at different stages from design to operational phase. The scientific literature reports several case studies related to the assessment of the individual components of the IEQ Tools aimed at the evaluation of the overall IEQ. The paper proposes an assessment tool based on the SB Method (Sustainable Building Method) and the Multi Criteria Analysis for the evaluation of IEQ during the operational phase of a building. Each component of IEQ is analysed through objective indicators and calculation methods. The tool provides two main outcomes: a global score expressing the overall performance of the building from the IEQ perspective; quantitative evaluations of all indoor comfort components through monitoring and measurement of the environmental variables. The above contributes to select intervention areas to optimize indoor design and to identify technologies aimed at ensuring the best IEQ levels for users at the operational stage. The system was applied to an open-plan working space of an office building. Monitoring activities and measurements are carried out to detect the indoor and outdoor variables affecting the IEQ. All aspects of IEQ were analysed and quantified so to evaluate the overall performance of the building and provide data to improve the working conditions

Working from Home in Italy during COVID-19 Lockdown: A Survey to Assess the Indoor Environmental Quality and Productivity

Italians were the first European citizens to experience the lockdown due to Sars-Cov-2 in March 2020. Most employees were forced to work from home. People suddenly had to share common living spaces with family members for longer periods of time and convert home spaces into workplaces. This inevitably had a subjective impact on the perception, satisfaction and preference of indoor environmental quality and work productivity. A web-based survey was designed and administered to Italian employees to determine how they perceived the indoor environmental quality of residential spaces when Working From Home (WFH) and to investigate the relationship between different aspects of users’ satisfaction. A total of 330 valid questionnaires were collected and analysed. The article reports the results of the analyses conducted using a descriptive approach and predictive models to quantify comfort in living spaces when WFH, focusing on respondents’ satisfaction. Most of them were satisfied with the indoor environmental conditions (89% as the sum of “very satisfied” and “satisfied” responses for thermal comfort, 74% for visual comfort, 68% for acoustic quality and 81% for indoor air quality), while the layout of the furniture negatively influenced the WFH experience: 45% of the participants expressed an unsatisfactory or neutral opinion. The results of the sentiment analysis confirmed this trend. Among the Indoor Environmental factors that affect productivity, visual comfort is the most relevant variable. As for the predictive approach using machine learning, the Support Vector Machine classifier performed best in predicting overall satisfaction

Serum ferritin as a predictor of treatment outcome in patients with chronic hepatitis C

OBJECTIVES: Antiviral treatment in chronic hepatitis C (CHC) involves ribavirin, a hemolytic agent. We planned a prospective study to evaluate whether drug-induced iron perturbation is clinically relevant as it relates to therapeutic outcome. METHODS: Iron variables were sequentially assessed in 206 CHC patients undergoing antiviral therapy and were correlated with pretreatment iron status and histology, hemolysis, and therapeutic outcome. RESULTS: At week 1 of therapy, serum iron (SI), transferrin saturation (TS), and serum ferritin (SF) increased markedly in all patients. All iron parameters correlated with hemolysis up to week 4; this correlation was lost for SF at later time points. SF rise during treatment was inversely related to baseline SF and iron deposits in hepatic mesenchymal/Kupffer cells. Both baseline SF and mesenchymal iron significantly correlated with fibrosis at multivariate analysis (P=0.015 and 0.008, respectively). Interestingly, baseline SF, despite good specificity (89%), had low sensitivity in predicting siderosis (25%). During therapy, SI, TS, and hemolysis parameters did not correlate with sustained virological response (SVR), whereas SF rise became an independent predictor of therapeutic response: a 2.5-fold increase of SF at week 12 associated with higher likelihood of SVR (odds ratio 1.91, P=0.032). Accordingly, lack of mesenchymal iron deposits at the baseline biopsy correlated with SVR (odds ratio 3.02, P=0.043). CONCLUSIONS: In CHC, SF is a useful marker for assessing disease duration and progression before starting treatment and for predicting therapeutic response while on therapy. SF rise during antiviral therapy is largely independent of hemolysis and likely indicates activation of macrophages in response to antivirals. © 2009 by the American College of Gastroenterology