QUANTITATIVE ELASTICITY IMAGING AND SOFT TISSUE CHARACTERIZATION USING TAGGED MAGNETIC RESONANCE IMAGING

Ph.DDOCTOR OF PHILOSOPH

Development and evaluation of machine learning models for voxel dose predictions in online adaptive magnetic resonance guided radiation therapy

PURPOSE: Daily online adaptive plan quality in magnetic resonance imaging guided radiation therapy (MRgRT) is difficult to assess in relation to the fully optimized, high quality plans traditionally established offline. Machine learning prediction models developed in this work are capable of predicting 3D dose distributions, enabling the evaluation of online adaptive plan quality to better inform adaptive decision-making in MRgRT. METHODS: Artificial neural networks predicted 3D dose distributions from input variables related to patient anatomy, geometry, and target/organ-at-risk relationships in over 300 treatment plans from 53 patients receiving adaptive, linac-based MRgRT for abdominal cancers. The models do not include any beam related variables such as beam angles or fluence and were optimized to balance errors related to raw dose and specific plan quality metrics used to guide daily online adaptive decisions. RESULTS: Averaged over all plans, the dose prediction error and the absolute error were 0.1 ± 3.4 Gy (0.1 ± 6.2%) and 3.5 ± 2.4 Gy (6.4 ± 4.3%) respectively. Plan metric prediction errors were -0.1 ± 1.5%, -0.5 ± 2.1%, -0.9 ± 2.2 Gy, and 0.1 ± 2.7 Gy for V95, V100, D95, and D CONCLUSION: Machine learning prediction models for treatment plan 3D dose distributions in online adaptive MRgRT were developed and tested. Clinical integration of the models requires minimal effort, producing 3D dose predictions for a new patient\u27s plan using only target and OAR structures as inputs. These models can enable improved workflows for MRgRT through more informed plan optimization and plan quality assessment in real time

Impact of ocean acidification on microzooplankton grazing dynamics

This study examines the potential impacts of projected atmospheric carbon dioxide (pCO2) levels reaching 800 ppm by the end of the century, focusing on ocean acidification effects on marine ecosystems in the coastal areas of Bohai. We investigated how acidification affects the grazing patterns of microzooplankton using dilution techniques and ecophysiological methods. Our findings indicate that acidic conditions shift the phytoplankton community structure, changing dominant species. Elevated CO2 concentrations reduced grazing pressure on phytoplankton, with less steep declines in growth rates at 800 ppm CO2 (spring: 2.43 d−1 vs. 2.16 d−1, summer: −0.46 d−1 vs. −0.73 d−1, autumn: −0.45 d−1 vs. −0.90 d−1) and significant decreases in grazing pressure percentages (%Pp from 0.84 to 0.58 and %Pi from 0.64 to 0.46). Short-term acid exposure significantly increased superoxide dismutase activity in both microplankton (from 0.03 to 0.08 U mg−1, p<0.01) and nanoplankton (from 0.05 to 0.09 U mg−1, p<0.001), indicating an adaptive response to oxidative stress. These results highlight that elevated CO2 levels primarily boost phytoplankton growth by reducing microzooplankton grazing pressure, resulting in higher growth rates and a shift towards smaller-sized phytoplankton, reflecting complex short-term ecological responses to acidification. Further research is needed to understand the long-term effects of ocean acidification on microzooplankton and their role in marine secondary productivity

UAV-assisted data dissemination based on network coding in vehicular networks

Efficient and emergency data dissemination service in vehicular networks (VN) is very important in some situations, such as earthquakes, maritime rescue, and serious traffic accidents. Data loss frequently occurs in the data transition due to the unreliability of the wireless channel and there are no enough available UAVs providing data dissemination service for the large disaster areas. UAV with an adjustable active antenna can be used in light of the situation. However, data dissemination assisted by UAV with the adjustable active antenna needs corresponding effective data dissemination framework. A UAV-assisted data dissemination method based on network coding is proposed. First, the graph theory to model the state of the data loss of the vehicles is used; the data dissemination problem is transformed as the maximum clique problem of the graph. With the coverage of the directional antenna being limited, a parallel method to find the maximum clique based on the region division is proposed. Lastly, the method\u27s effectiveness is demonstrated by the simulation; the results show that the solution proposed can accelerate the solving process of finding the maximum clique and reduce the number of UAV broadcasts. This manuscript designs a novel scheme for the UAV-assisted data dissemination in vehicular networks based on network coding. The graph theory is used to model the state of the data loss of the vehicles. With the coverage of the directional antenna being limited, then a parallel method is proposed to find the maximum clique of the graph based on the region division. The effectiveness of the method is demonstrated by the simulation

UAV-Assisted Sensor Data Dissemination in mmWave Vehicular Networks Based on Network Coding

Due to good maneuverability, UAVs and vehicles are often used for environment perception in smart cities. In order to improve the efficiency of sensor data sharing in UAV-assisted mmWave vehicular network (VN), this paper proposes a sensor data sharing method based on blockage effect identification and network coding. The concurrent sending vehicles selection method is proposed based on the availability of mmWave link, the number of target vehicles of sensor data packet, the distance between a sensor data packet and target vehicle, the number of concurrent sending vehicles, and the waiting time of sensor data packet. The construction method of the coded packet is put forward based on the status information about the existing packets of vehicles. Simulation results demonstrated that efficiency of the proposed method is superior to baseline solutions in terms of the packet loss ratio, transmission time, and packet dissemination ratio

Efficient Message Dissemination on Curve Road in Vehicular Networks

Effective emergency message dissemination is a great importance on a specific road in vehicular networks (VN). The existing methods are not most efficient solutions for message dissemination on the curve road, which primarily focus on highway and urban road. In order to improve the efficiency of message dissemination on the curved road, the paper proposed a message dissemination method based on bidirectional relay nodes. The message can be disseminated in two directions simultaneously. The paper designed a relay node selection method based on the neighbor nodes’ coverage length of the road. Different waiting delays are assigned to the neighbor nodes according to the cover capability of the road in which the message has not arrived. Simulation results demonstrated that the efficiency of the proposed method is superior to the common solutions in terms of the contention delay and the propagation velocity