Chemoenzymatic synthesis of sulfoquinovosylmonoacylglycerols (SQMG) as anti-tumor-promoters

During our search for new glycoglycerolipids active in cancer chemoprevention, in recent years we have synthesized a number of esters of 2-O-beta-D-glycosylglycerols in which the length, shape, number and position of the acyl chain, and the type of sugar (alpha\uf020and beta glucose or galactose) were varied. These compounds were found to be very active in inhibiting the tumor-promoting activity of the phorbol ester TPA both in in vitro and in in vivo tests, being such activities mainly influenced by the changes of the acyl chains length. Sulfoquinovosylacylglycerols are acylated sulfoglycolipids in which sulfoquinovose (6-deoxy-6-sulfo-glucose) is alpha-linked to the sn-3 position of glycerol. These compounds exhibit noteworthy biological activities, that make them very attractive for their use in cancer therapy. Here we report the synthesis of 6\u2019-sulfo-derivatives (SQMG) based on the skeleton of 2-O-beta-D-glucosylglycerol to which previously synthesized biologically active glucoglycerolipid analogues are related. A chemoenzymatic strategy has been used to selectively insert the proper chemical functionalities (i.e. acyl chain) at the desired position of glucosylglycerol to obtain the target compounds. Their potential as anti-tumor-promoters will be also discussed

Synthetic Lick Indices and Detection of α-enhanced Stars. II. F, G, and K Stars in the –1.0 < [Fe/H] < +0.50 Range

We present an analysis of 402 F, G, and K solar neighborhood stars, with accurate estimates of [Fe/H] in the range -1.0 to +0.5 dex, aimed at the detection of α-enhanced stars and at the investigation of their kinematical properties. The analysis is based on the comparison of 571 sets of spectral indices in the Lick/IDS system, coming from four different observational data sets, with synthetic indices computed with solar-scaled abundances and with α-element enhancement. We use selected combinations of indices to single out α-enhanced stars without requiring previous knowledge of their main atmospheric parameters. By applying this approach to the total data set, we obtain a list of 60 bona fide α-enhanced stars and of 146 stars with solar-scaled abundances. The properties of the detected α-enhanced and solar-scaled abundance stars with respect to their [Fe/H] values and kinematics are presented. A clear kinematic distinction between solar-scaled and α-enhanced stars was found, although a one-to-one correspondence to "thin disk" and "thick disk" components cannot be supported with the present data

Universal parity effects in the entanglement entropy of XX chains with open boundary conditions

We consider the Renyi entanglement entropies in the one-dimensional XX spin-chains with open boundary conditions in the presence of a magnetic field. In the case of a semi-infinite system and a block starting from the boundary, we derive rigorously the asymptotic behavior for large block sizes on the basis of a recent mathematical theorem for the determinant of Toeplitz plus Hankel matrices. We conjecture a generalized Fisher-Hartwig form for the corrections to the asymptotic behavior of this determinant that allows the exact characterization of the corrections to the scaling at order o(1/l) for any n. By combining these results with conformal field theory arguments, we derive exact expressions also in finite chains with open boundary conditions and in the case when the block is detached from the boundary.Comment: 24 pages, 9 figure

String correlation functions of the spin-1/2 Heisenberg XXZ chain

We calculate certain string correlation functions, originally introduced as order parameters in integer spin chains, for the spin-1/2 XXZ Heisenberg chain at zero temperature and in the thermodynamic limit. For small distances, we obtain exact results from Bethe Ansatz and exact diagonalization, whereas in the large-distance limit, field-theoretical arguments yield an asymptotic algebraic decay. We also make contact with two-point spin-correlation functions in the asymptotic limit.Comment: 23 pages, 4 figures. An incomplete discussion on the limit to the spin-spin correlation function is corrected on page 1

Universal corrections to scaling for block entanglement in spin-1/2 XX chains

We consider the R\'enyi entropies $S_n(\ell)$ in the one dimensional spin-1/2 Heisenberg XX chain in a magnetic field. The case n=1 corresponds to the von Neumann ``entanglement'' entropy. Using a combination of methods based on the generalized Fisher-Hartwig conjecture and a recurrence relation connected to the Painlev\'e VI differential equation we obtain the asymptotic behaviour, accurate to order ${\cal O}(\ell^{-3})$, of the R\'enyi entropies $S_n(\ell)$ for large block lengths $\ell$. For n=1,2,3,10 this constitutes the 3,6,10,48 leading terms respectively. The o(1) contributions are found to exhibit a rich structure of oscillatory behaviour, which we analyze in some detail both for finite $n$ and in the limit $n\to\infty$.Comment: 25 pages, 5 figure

Chiseling and gypsum application affecting soil physical attributes, root growth and soybean yield

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Synthetic Mid-UV Spectroscopic Indices of Stars

Using the UVBLUE library of synthetic stellar spectra we have computed a set of mid-UV line and continuum spectroscopic indices. We explore their behavior in terms of the leading stellar parameters [T_eff,log(g)]. The overall result is that synthetic indices follow the general trends depicted by those computed from empirical databases. Separately we also examine the index sensitivity to changes in chemical composition, an analysis only feasible under a theoretical approach. In this respect, lines indices FeI3000, BL3096 and MgI2852 and the continuum index 2828/2921 are the least sensitive features, an important characteristic to be taken into account for the analyses of integrated spectra of stellar systems. We also quantify the effects of instrumental resolution on the indices and find that indices display variations up to 0.1 mag in the resolution interval between 6-10 angstrom of FWHM. We discuss the extent to which synthetic indices are compatible with indices measured in spectra collected by the International Ultraviolet Explorer (IUE). Five line and continuum indices (FeI3000, 2110/2570, 2828/2921, S2850, and S2850L) display a remarkable good correlation with observations. The rest of the indices are either underestimated or overestimated, however, two of them, MgWide and BL3096, display only marginal discrepancies. For 11 indices we give the coefficients to convert synthetic indices to the IUE system. This work represents the first attempt to synthesize mid-UV indices from high resolution theoretical spectra and foresees important applications for the study of the ultraviolet morphology of old stellar aggregates.Comment: 20 pages, 6 figures; accepted for publication in The Astrophysical Journa

Diversidade genética por AFLP de Colletotrichum gloeosporioides E C. kahawae isolados de cafeeiros.

A diversidade genética entre 33 isolados de Colletotrichum. gloeosporioides oriundos de diferentes lavouras cafeeiras e um isolado (DNA) de C. kahawae, cedido pelo CIFC, Portugal, foi estudada utilizando o marcador AFLP. As três combinações de pares de oligonucleotídeos AFLP geraram 187 bandas polimórficas que foram utilizadas no agrupamento UPGMA. De acordo com o dendrograma, ao nível de 90% de distância genética foram definidos quatro grupos: 1) formado de 15 isolados de Minas Gerais, 2 de São Paulo e 1 do Paraná; 2) um isolado de MG; 3) 10 de MG, 3 do Espírito Santo e um de SP; 4) composto apenas por C. kahawae. Alguns dos isolados de C. gloeosporioides compartilharam alta similaridade entre eles, e outros, apresentaram grande distância genética. Não ocorreu associação de C. gloeosporioides com as regiões geográficas amostradas e as variedades de onde foram isolados. A análise do dendrograma mostrou que C. kahawae (patogênico ao cafeeiro) não agrupou com nenhum dos isolados de C. gloeosporioides, mostrando alta divergência genética (aproximadamente 100%) em relação a eles. O padrão de bandas AFLP mostrou que C. kahawae é geneticamente distinto de C. gloeosporioides

Reversed anisotropies and thermal contraction of FCC (110) surfaces

The observed anisotropies of surface vibrations for unreconstructed FCC metal (110) surfaces are often reversed from the "common sense" expectation. The source of these reversals is investigated by performing ab initio density functional theory calculations to obtain the surface force constant tensors for Ag(110), Cu(110) and Al(110). The most striking result is a large enhancement in the coupling between the first and third layers of the relaxed surface, which strongly reduces the amplitude of out-of-plane vibrations of atoms in the first layer. This also provides a simple explanation for the thermal contraction of interlayer distances. Both the anisotropies and the thermal contraction arise primarily as a result of the bond topology, with all three (110) surfaces showing similar behavior.Comment: 13 pages, in revtex format, plus 1 postscript figur