Centerscope

Centerscope, formerly Scope, was published by the Boston University Medical Center "to communicate the concern of the Medical Center for the development and maintenance of improved health care in contemporary society.

Antifungal coatings by caspofungin immobilization onto biomaterials surfaces via a plasma polymer interlayer

Published Online: 14 October 2015Not only bacteria but also fungal pathogens, particularly Candida species, can lead to biofilm infections on biomedical devices. By covalent grafting of the antifungal drug caspofungin, which targets the fungal cell wall, onto solid biomaterials, a surface layer can be created that might be able to provide long-term protection against fungal biofilm formation. Plasma polymerization of propionaldehyde (propanal) was used to deposit a thin (∼20 nm) interfacial bonding layer bearing aldehyde surface groups that can react with amine groups of caspofungin to form covalent interfacial bonds for immobilization. Surface analyses by x-ray photoelectron spectroscopy and time-of-flight secondary ion mass spectrometry confirmed the intended grafting and uniformity of the coatings, and durability upon extended washing. Testing for fungal cell attachment and ensuing biofilm formation showed that caspofungin retained activity when covalently bound onto surfaces, disrupting colonizing Candida cells. Mammalian cytotoxicity studies using human primary fibroblasts indicated that the caspofungin-grafted surfaces were selective in eliminating fungal cells while allowing attachment and spreading of mammalian cells. These in vitro data suggest promise for use as antifungal coatings, for example, on catheters, and the use of a plasma polymer interlayer enables facile transfer of the coating method onto a wide variety of biomaterials and biomedical devices.Stefani S. Griesser, Marek Jasieniak, Bryan R. Coad, and Hans J. Griesse

Prinsip-prinsip Kimia Medisinal jil 1

xviii.953 hal.;21 c

Prinsip-prinsip kimia medisinal

Judul asli: Principles of medicinal chemistryJilid 1xviii, 953 p. : il.; 21 cm

Prinsip-Prinsip Kimia Medisinal : Jilid I

YogyakartaV.1, xviii, 953 p, ilus, 23 c

Prinsip-prisip Kimia medisinal

xviii+953hlm.;22c

Principles of medical chemistry

861 p. : il.; 29 cm

Prinsip-prinsip kimia medisinal, jld. 1 dan jld. 2

Judul asli: Prinsiple of medical chemistryBibl. : setiap bab.Indeks2 jil. ( ix, 953; ix, 1848 hlm. ) : il. ; 22 cm