A Model to Estimate Sediment Yield from Field-Sized Areas: Development of Model

A tool for evaluating sediment yield from field-sized areas is needed for planning management practices to control sediment yield. We developed a reasonably simple simulation model which incorporates fundamental principles of erosion, deposition, and sediment transport mechanics. The model summarizes the state-of-the-art in erosion and sediment yield modeling with appropriate simplifications required to couple the governing equations. Limited testing showed that the procedures developed here give improved estimates over the Universal Soil Loss Equation. Specific components of the model were tested using experimental data from overland flow, erodible channel, and impoundment studies. These results suggest that the model produces reasonable estimates of erosion, sediment transport, and deposition under a variety of circumstances common to field-scale areas. Alternative management practices such as conservation tillage, terracing, and contouring can be evaluated separately or in combination to determine their influence on sediment yield. Given a particular location with specified characteristics for climate, soils, topography, and crops, the model provides a means of evaluating alternative management practices to suit a particular farming operation

The role of macrophages in Staphylococcus aureus infection

Staphylococcus aureus is a member of the human commensal microflora that exists, apparently benignly, at multiple sites on the host. However, as an opportunist pathogen it can also cause a range of serious diseases. This requires an ability to circumvent the innate immune system to establish an infection. Professional phagocytes, primarily macrophages and neutrophils, are key innate immune cells which interact with S. aureus, acting as gatekeepers to contain and resolve infection. Recent studies have highlighted the important roles of macrophages during S. aureus infections, using a wide array of killing mechanisms. In defense, S. aureus has evolved multiple strategies to survive within, manipulate and escape from macrophages, allowing them to not only subvert but also exploit this key element of our immune system. Macrophage-S. aureus interactions are multifaceted and have direct roles in infection outcome. In depth understanding of these host-pathogen interactions may be useful for future therapeutic developments. This review examines macrophage interactions with S. aureus throughout all stages of infection, with special emphasis on mechanisms that determine infection outcome

An Updated Description of Heavy-Hadron Interactions in Geant-4

Exotic stable massive particles (SMP) are proposed in a number of scenarios of physics beyond the Standard Model. It is important that LHC experiments are able both to detect and extract the quantum numbers of any SMP with masses around the TeV scale. To do this, an understanding of the interactions of SMPs in matter is required. In this paper a Regge-based model of R-hadron scattering is extended and implemented in Geant-4. In addition, the implications of $R$-hadron scattering for collider searches are discussed

Clonal population expansion of Staphylococcus aureus occurs due to escape from a finite number of intraphagocyte niches

Staphylococcus aureus is a human commensal and also an opportunist pathogen causing life threatening infections. During S. aureus disease, the abscesses that characterise infection can be clonal, whereby a large bacterial population is founded by a single or few organisms. Our previous work has shown that macrophages are responsible for restricting bacterial growth such that a population bottleneck occurs and clonality can emerge. A subset of phagocytes fail to control S. aureus resulting in bacterial division, escape and founding of microabscesses that can seed other host niches. Here we investigate the basis for clonal microabscess formation, using in vitro and in silico models of S. aureus macrophage infection. Macrophages that fail to control S. aureus are characterised by formation of intracellular bacterial masses, followed by cell lysis. High-resolution microscopy reveals that most macrophages had internalised only a single S. aureus, providing a conceptual framework for clonal microabscess generation, which was supported by a stochastic individual-based, mathematical model. Once a threshold of masses was reached, increasing the number of infecting bacteria did not result in greater mass numbers, despite enhanced phagocytosis. This suggests a finite number of permissive, phagocyte niches determined by macrophage associated factors. Increased understanding of the parameters of infection dynamics provides avenues for development of rational control measures

(p,n) Experiments at IUCF

This work was supported by National Science Foundation Grants PHY 76-84033A01, PHY 78-22774, and Indiana Universit

Enacting corporate governance of health care safety and quality: a dramaturgy of hospital boards in England

The governance of patient safety is a challenging concern for all health systems. Yet, while the role of executive Boards receives increased scrutiny, the area remains theoretically and methodologically underdeveloped. Specifically, we lack a detailed understanding of the performative aspects at play: what Board members say and do to discharge their accountabilities for patient safety. This article draws on qualitative data from overt non-participant observation of four NHS hospital Foundation Trust Boards in England. Applying a dramaturgical framework to explore scripting, setting, staging and performance, we found important differences between case study sites in the performative dimensions of processing and interpretation of infection control data. We detail the practices associated with these differences - the legitimation of current performance, the querying of data classification, and the naming and shaming of executives – to consider their implications

Changes in the ceIl membrane of Lactobacillus bulgaricus during storage following freeze-drying

The mechanism of inactivation of freeze-dried Lactobacillus bulgaricus during storage in maltodextrin under controlled humidity was investigated. Evidence is presented supporting the hypothesis that membrane damage occurs during storage. A study on the lipid composition of the cells by gas chromatography showed a decrease in the unsaturated and saturated fatty acid content of the cell. Further evidence indicating membrane damage includes a decrease in membrane bound proton-translocating ATPase activity