Chemotherapy-induced alopecia management: Clinical experience and practical advice

Background: Chemotherapy-induced alopecia (CIA) is probably one of the most shocking aspects for oncological patients and underestimated by physicians. Among hair loss risk factors, there are treatment-related aspects such as drug dose, admin- istration regimen, and exposure to X-rays, but also patient-related characteristics. To the best of our knowledge, no guidelines are available about CIA management. Aims and methods: With this study, based on literature background and our clinical experience, we would like to propose a list of actions in order to estimate the risk of hair loss before starting chemotherapy and to manage this condition before, dur- ing, and after drug administration and to create a sort of practical guide for derma- tologists and oncologists. Results and conclusion: There is an urgent need for prospective studies to clarify the mechanistic basis of alopecia associated with these drugs and consequently to design evidence-based management strategies

Multi-therapies in androgenetic alopecia: review and clinical experiences.

Androgenetic alopecia (AGA) is a genetically determined progressive hair-loss condition which represents the most common cause of hair loss in men. The use of the medical term androgenetic alopecia reflects current knowledge about the important role of androgens and genetic factors in its etiology. In addition to androgen-dependent changes in the hair cycle, sustained microscopic follicular inflammation contributes to its onset. Furthermore, Prostaglandins have been demonstrated to have the ability in modulating hair follicle cycle; in particular, PGD2 inhibits hair growth while PGE2/F2a promote growth. Due to the progressive nature of AGA, the treatment should be started early and continued indefinitely, since the benefit will not be maintained upon ceasing therapy. To date, only two therapeutic agents have been approved by the Food and Drug Administration and European Medicines Agency for the treatment of AGA: topical minoxidil and oral finasteride. Considering the many pathogenetic mechanisms involved in AGA, various treatment options are available: topical and systemic drugs may be used and the choice depends on various factors including grading of AGA, patients’ pathological conditions, practicability, costs and risks. So, the treatment for AGA should be based on personalized therapy and targeted at the different pathophysiological aspects of AG

Neuobičajeno opažanje prugastog dupina (Stenella coeruleoalba) u Kvarneriću, Sjeverni Jadran

An adult striped dolphin, Stenella coeruleoalba, was encountered east of the island of Lošinj on 6 May 1996, and observed from a small inflatable boat for 5 hours. The only cetacean species that has been consistently observed in the Northern Adriatic Sea in the last decades is the bottlenose dolphin, Tursiops truncatus. Occasional reports of striped dolphins in the Central and Northern Adriatic Sea may simply reflect the occurrence of stray individuals, but the fact that such observations have only occurred recently might be indicative of a progressive extension of the striped dolphin\u27s range, as has been reported for other Mediterranean areas.Odrasli prugasti dupin, Stenella coeruleoalba, opažen je istočno od otoka Lošinja 6. svibnja 1996. godine i promatran tijekom pet sati iz malog gumenog čamca. Jedina vrsta reda Cetacea (kitovi) koja je redovito viđana u Sjevernom Jadranu posljednjih desetljeća, bio je dobri dupin, Tursiops truncatus. Povremena opažanja prugastog dupina u Srednjem i Sjevernom Jadranu možda su samo pojave zalutalih jedinki, ali činjenica da su se ta opažanja zbila nedavno možda su indikacija progresivnog širenja areala prugastog dupina, a zabilježena su i u drugim dijelovima Sredozemlja

A case of Scalp Rosacea treated with low dose doxycycline and probiotic therapy and literature review on therapeutic options

Rosacea is a common chronic inflammatory disorder showing a wide range of clinical features such as telangiectasia, erythema, papules, and pustules primarily involving the central part of face (forehead, cheeks and nose) although extra facial manifestation have been described. We describe a case of rosacea with predominant scalp involvement successfully treated with a 8-week-course of doxycycline 40 mg once a day and probiotic therapy twice a day (Bifidobacterium breve BR03, Lactobacillus salivarius LS01 1 × 10(9) UFC/dose)

Androgenetic alopecia: a review

Purpose Androgenetic alopecia, commonly known as male pattern baldness, is the most common type of progressive hair loss disorder in men. The aim of this paper is to review recent advances in understanding the pathophysiology and molecular mechanism of androgenetic alopecia. Methods Using the PubMed database, we conducted a systematic review of the literature, selecting studies pub- lished from 1916 to 2016. Results The occurrence and development of androgenetic alopecia depends on the interaction of endocrine factors and genetic predisposition. Androgenetic alopecia is character- ized by progressive hair follicular miniaturization, caused by the actions of androgens on the epithelial cells of genetically susceptible hair follicles in androgen-dependent areas. Although the exact pathogenesis of androgenetic alopecia remains to be clari fi ed, research has shown that it is a polygenetic condition. Numerous studies have unequi- vocally identi fi ed two major genetic risk loci for androge- netic alopecia, on the X-chromosome AR ⁄ EDA2R locus and the chromosome 20p11 locus. Conclusions Candidate gene and genome-wide association studies have reported that single-nucleotide polymorphisms at different genomic loci are associated with androgenetic alopecia development. A number of genes determine the predisposition for androgenetic alopecia in a polygenic fashion. However, further studies are needed before the specific genetic factors of this polygenic condition can be fully explaine

Clinical, Histological and Trichoscopic Correlations in Scalp Disorders

Trichoscopy is the term coined for the dermoscopic imaging of scalp and hair. This diagnostic technique, simple and noninvasive, can be used as a handy bedside tool for the diagnosis and follow-up of hair and scalp disorders. It allows the recognition of morphologic structures not visible by the naked eye and provides the clinician with a range of dermoscopic findings necessary for differential diagnosis. Trichoscopy observation can be broadly grouped as interfollicular patterns and follicular patterns. Recently, a third mixed class, called the follicular plus interfollicular pattern, has been introduced. Some of these features are specific to a certain scalp disease, while others can be found in many hair disorders. Although studies suggest that the use of trichoscopy can improve clinical accuracy, further investigation is needed. This review provides update information on the trichoscopic features of the most common scalp disorders, striving to show a histopathological and clinical correlation

Dugoročno praćenje samotnog prugastog dupina (Stenella coeruleoalba) u priobalnom području Vinodolskog kanala, sjeverni Jadran

The striped dolphin (Stenella coeruleoalba) is not a common cetacean species in the northern Adriatic Sea. Its presence is generally related to deeper offshore areas beyond the continental shelf. Despite this fact, the analysis of data collected over the past 5 years indicates unusual site fidelity of a single individual in the relatively shallow Vinodol Channel of the northern Croatian Adriatic Sea. Summarizing the available data on its recent occurrence, this paper contributes to the current limited knowledge on striped dolphin presence and associations not only in this region.Prugasti dupin (Stenella coeruleoalba) ne predstavlja uobičajenu vrstu za hrvatski dio sjevernog Jadrana. Obično nastanjuje duboka i otvorena mora iza kontinentalnog šelfa. Unatoč tome, analiza podataka sakupljenih tijekom proteklih 5 godina ukazuje na neuobičajenu privrženost jedinke prugastog dupina relativno plitkom području Vinodolskog kanala u hrvatskom dijelu sjevernog Jadrana. Sveukupni podaci o njegovom pojavljivanju predstavljeni su u ovom radu, pridonoseći time dosadašnjim ograničenim saznanjima o prisutnosti prugastih dupina, i to ne samo na ovom području

Chemotherapy-induced alopecia: A novel observation

no abstract avaibl

Dermoscopy and methyl aminolevulinate: A study for detection and evaluation of field cancerization

Actinic keratosis (AK) is a keratinocyte intraepidermal neoplasia UV light – induced that frequently appears in sun-exposed areas of the skin. Although historically AK was de fi ned as “ precancerous ” , actually it is considered as the earliest stage of squamous cell carcinoma (SCC) in situ. Since AKs can progress into invasive SCC, their treatment isrecommended. AKsrarely developasa singlelesion;usually multiplelesions commonly affect anen- tire area of chronically actinic damaged skin. This has led to the concept of “ fi eld cancerization ” , an area chroni- cally sun-exposed that surrounds peripherally visible lesions, in which are individualized subclinical alterations. One of the main principles endpoint in the management of AKs is the evaluation and the treatment of fi eld cancerization. In this view, in order to detect and quantify fi eld cancerization, we employed a method based on the topical application of methyl aminolevulinate (MAL) and the detection of the fl uorescence emitted by its metabolite Protoporphyrin IX (PpIX); then, considering the extension and the intensity of measured fl uores- cence, we create a score of fi eld cancerization. The results show that patients underwent to daylight PDT had a reduction of total score, from T0 to T2. Whereas in the group untreated we observed a stability of total score or a slightly worse. So, the method and the score used allows to evaluate with a good approximation the dimension of fi eld cancerization and show the modi fi cation of it after treatment