Diez para Dios. El diezmo y su arrendamiento en el Valle de Toluca, 1650 1700

Durante el periodo novohispano, el arrendamiento y la cobranza del diezmo eclesiástico estuvieron ligados íntimamente a la actividad productiva de la tierra, sobre todo a la agricultura y ganadería. El Valle de Toluca fue un bastión importante en el arrendamiento del diezmo, de acuerdo con los protocolos de la Notaría N° 1 de Toluca. En la transacción económica Iglesiaparticulares podemos encontrar hacendados de renombre y/o personas que se prestaban como fiadores para la actividad que redituó ganancias a la Iglesia católica. Para la argumentación de este artículo se consultaron fuentes primarias de archivo, siendo el principal el Archivo General de Notarías del Estado de México, en su sección histórica.Durante el periodo novohispano, el arrendamiento y la cobranza del diezmo eclesiástico estuvieron ligados íntimamente a la actividad productiva de la tierra, sobre todo a la agricultura y ganadería. El Valle de Toluca fue un bastión importante en el arrendamiento del diezmo, de acuerdo con los protocolos de la Notaría N° 1 de Toluca. En la transacción económica Iglesiaparticulares podemos encontrar hacendados de renombre y/o personas que se prestaban como fiadores para la actividad que redituó ganancias a la Iglesia católica. Para la argumentación de este artículo se consultaron fuentes primarias de archivo, siendo el principal el Archivo General de Notarías del Estado de México, en su sección histórica

La formación del Historiador. Áreas terminales, prácticas profesionales, servicio social y tutorías en las Licenciaturas en Historia en México

Hoy en las licenciaturas en Historia un fantasma recorre la enseñanza de la disciplina: el fantasma de las competencias diseñadas por el mercado laboral neoliberal. En las universidades mexicanas la enseñanza de la Historia como disciplina estuvo orientada a la investigación, al menos durante la segunda mitad del siglo XX. La mayoría de las licenciaturas fundadas en este periodo tomaron como modelo el plan de estudios de la UNAM. Por ejemplo, las carreras de Historia que se fundaron en 1945 en el Instituto de Historia de la Universidad Nacional Autónoma de México y en la casa de España, hoy Colegio de México, y la que se estableció..

Factorial Equivalence of the Social Skills Scale in the Lambayeque University Context According to Sex

This study aimed to show whether the theoretical model of the social skills construct, proposed by Gismero (2000), is invariant in male and female samples of Peruvian university students from Lambayeque. In order to meet the proposed objective, a non-experimental, cross-sectional, comparative psychometric design by hierarchical confirmatory procedures was chosen. Two samples of university students were used, one of 1,084 female students and the other of 1,043 male students. Both groups were applied the self-report of social skills (EHS). With the data obtained, a confirmatory factor analysis of the first-order factor structure of the social skills construct was performed in each group, based on the polychoric correlation matrix. The invariance of the scale according to sex was evaluated on the basis of the second-order factor structure, by means of multigroup confirmatory factor analysis of nested models. No significant differences in the fit to the data were found between the two-factor second-order factor structure and the alternative one-factor model. Consecutive tests of configurational invariance, disturbance, and first- and second-order metrics gave evidence, respectively, that the model structure, second-order factor errors, and first- and second-order loadings are equivalent in the two study samples. With the data from the study, it is concluded that the structure of the EHS scale is invariant to the sex variable in the Lambayeque context

MHC class I-related chain A and B ligands are differentially expressed in human cervical cancer cell lines

<p>Abstract</p> <p>Background</p> <p>Natural killer (NK) cells are an important resource of the innate immune system directly involved in the spontaneous recognition and lysis of virus-infected and tumor cells. An exquisite balance of inhibitory and activating receptors tightly controls the NK cell activity. At present, one of the best-characterized activating receptors is NKG2D, which promotes the NK-mediated lysis of target cells by binding to a family of cell surface ligands encoded by the MHC class I chain-related (MIC) genes, among others. The goal of this study was to describe the expression pattern of MICA and MICB at the molecular and cellular levels in human cervical cancer cell lines infected or not with human papillomavirus, as well as in a non-tumorigenic keratinocyte cell line.</p> <p>Results</p> <p>Here we show that MICA and MICB exhibit differential expression patterns among HPV-infected (SiHa and HeLa) and non-infected cell lines (C33-A, a tumor cell line, and HaCaT, an immortalized keratinocyte cell line). Cell surface expression of MICA was higher than cell surface expression of MICB in the HPV-positive cell lines; in contrast, HPV-negative cells expressed lower levels of MICA. Interestingly, the MICA levels observed in C33-A cells were overcome by significantly higher MICB expression. Also, all cell lines released higher amounts of soluble MICB than of soluble MICA into the cell culture supernatant, although this was most pronounced in C33-A cells. Additionally, Real-Time PCR analysis demonstrated that MICA was strongly upregulated after genotoxic stress.</p> <p>Conclusions</p> <p>This study provides evidence that even when MICA and MICB share a high degree of homology at both genomic and protein levels, differential regulation of their expression and cell surface appearance might be occurring in cervical cancer-derived cells.</p

Augmented serum level of major histocompatibility complex class I-related chain A (MICA) protein and reduced NKG2D expression on NK and T cells in patients with cervical cancer and precursor lesions

<p>Abstract</p> <p>Background</p> <p>Cervical cancer is the second most common cancer in women worldwide. NK and cytotoxic T cells play an important role in the elimination of virus-infected and tumor cells through NKG2D activating receptors, which can promote the lysis of target cells by binding to the major histocompatibility complex class I-related chain A (MICA) proteins. Increased serum levels of MICA have been found in patients with epithelial tumors. The aim of this study was to compare the levels of soluble MICA (sMICA) and NKG2D-expressing NK and T cells in blood samples from patients with cervical cancer or precursor lesions with those from healthy donors.</p> <p>Methods</p> <p>Peripheral blood with or without heparin was collected to obtain mononuclear cells or sera, respectively. Serum sMICA levels were measured by ELISA and NKG2D-expressing immune cells were analyzed by flow cytometry. Also, a correlation analysis was performed to associate sMICA levels with either NKG2D expression or with the stage of the lesion.</p> <p>Results</p> <p>Significant amounts of sMICA were detected in sera from nearly all patients. We found a decrease in the number of NKG2D-expressing NK and T cells in both cervical cancer and lesion groups when compared to healthy donors. Pearson analysis showed a negative correlation between sMICA and NKG2D-expressing T cells; however, we did not find a significant correlation when the analysis was applied to sMICA and NKG2D expression on NK cells.</p> <p>Conclusion</p> <p>Our results show for the first time that high sMICA levels are found in sera from patients with both cervical cancer and precursor lesions when compared with healthy donors. We also observed a diminution in the number of NKG2D-expressing NK and T cells in the patient samples; however, a significant negative correlation between sMICA and NKG2D expression was only seen in T cells.</p

Effect of Hydrocortisone on Mortality and Organ Support in Patients With Severe COVID-19: The REMAP-CAP COVID-19 Corticosteroid Domain Randomized Clinical Trial.

Importance: Evidence regarding corticosteroid use for severe coronavirus disease 2019 (COVID-19) is limited. Objective: To determine whether hydrocortisone improves outcome for patients with severe COVID-19. Design, Setting, and Participants: An ongoing adaptive platform trial testing multiple interventions within multiple therapeutic domains, for example, antiviral agents, corticosteroids, or immunoglobulin. Between March 9 and June 17, 2020, 614 adult patients with suspected or confirmed COVID-19 were enrolled and randomized within at least 1 domain following admission to an intensive care unit (ICU) for respiratory or cardiovascular organ support at 121 sites in 8 countries. Of these, 403 were randomized to open-label interventions within the corticosteroid domain. The domain was halted after results from another trial were released. Follow-up ended August 12, 2020. Interventions: The corticosteroid domain randomized participants to a fixed 7-day course of intravenous hydrocortisone (50 mg or 100 mg every 6 hours) (n = 143), a shock-dependent course (50 mg every 6 hours when shock was clinically evident) (n = 152), or no hydrocortisone (n = 108). Main Outcomes and Measures: The primary end point was organ support-free days (days alive and free of ICU-based respiratory or cardiovascular support) within 21 days, where patients who died were assigned -1 day. The primary analysis was a bayesian cumulative logistic model that included all patients enrolled with severe COVID-19, adjusting for age, sex, site, region, time, assignment to interventions within other domains, and domain and intervention eligibility. Superiority was defined as the posterior probability of an odds ratio greater than 1 (threshold for trial conclusion of superiority >99%). Results: After excluding 19 participants who withdrew consent, there were 384 patients (mean age, 60 years; 29% female) randomized to the fixed-dose (n = 137), shock-dependent (n = 146), and no (n = 101) hydrocortisone groups; 379 (99%) completed the study and were included in the analysis. The mean age for the 3 groups ranged between 59.5 and 60.4 years; most patients were male (range, 70.6%-71.5%); mean body mass index ranged between 29.7 and 30.9; and patients receiving mechanical ventilation ranged between 50.0% and 63.5%. For the fixed-dose, shock-dependent, and no hydrocortisone groups, respectively, the median organ support-free days were 0 (IQR, -1 to 15), 0 (IQR, -1 to 13), and 0 (-1 to 11) days (composed of 30%, 26%, and 33% mortality rates and 11.5, 9.5, and 6 median organ support-free days among survivors). The median adjusted odds ratio and bayesian probability of superiority were 1.43 (95% credible interval, 0.91-2.27) and 93% for fixed-dose hydrocortisone, respectively, and were 1.22 (95% credible interval, 0.76-1.94) and 80% for shock-dependent hydrocortisone compared with no hydrocortisone. Serious adverse events were reported in 4 (3%), 5 (3%), and 1 (1%) patients in the fixed-dose, shock-dependent, and no hydrocortisone groups, respectively. Conclusions and Relevance: Among patients with severe COVID-19, treatment with a 7-day fixed-dose course of hydrocortisone or shock-dependent dosing of hydrocortisone, compared with no hydrocortisone, resulted in 93% and 80% probabilities of superiority with regard to the odds of improvement in organ support-free days within 21 days. However, the trial was stopped early and no treatment strategy met prespecified criteria for statistical superiority, precluding definitive conclusions. Trial Registration: ClinicalTrials.gov Identifier: NCT02735707

Impact of opioid-free analgesia on pain severity and patient satisfaction after discharge from surgery: multispecialty, prospective cohort study in 25 countries

Background: Balancing opioid stewardship and the need for adequate analgesia following discharge after surgery is challenging. This study aimed to compare the outcomes for patients discharged with opioid versus opioid-free analgesia after common surgical procedures.Methods: This international, multicentre, prospective cohort study collected data from patients undergoing common acute and elective general surgical, urological, gynaecological, and orthopaedic procedures. The primary outcomes were patient-reported time in severe pain measured on a numerical analogue scale from 0 to 100% and patient-reported satisfaction with pain relief during the first week following discharge. Data were collected by in-hospital chart review and patient telephone interview 1 week after discharge.Results: The study recruited 4273 patients from 144 centres in 25 countries; 1311 patients (30.7%) were prescribed opioid analgesia at discharge. Patients reported being in severe pain for 10 (i.q.r. 1-30)% of the first week after discharge and rated satisfaction with analgesia as 90 (i.q.r. 80-100) of 100. After adjustment for confounders, opioid analgesia on discharge was independently associated with increased pain severity (risk ratio 1.52, 95% c.i. 1.31 to 1.76; P &lt; 0.001) and re-presentation to healthcare providers owing to side-effects of medication (OR 2.38, 95% c.i. 1.36 to 4.17; P = 0.004), but not with satisfaction with analgesia (beta coefficient 0.92, 95% c.i. -1.52 to 3.36; P = 0.468) compared with opioid-free analgesia. Although opioid prescribing varied greatly between high-income and low- and middle-income countries, patient-reported outcomes did not.Conclusion: Opioid analgesia prescription on surgical discharge is associated with a higher risk of re-presentation owing to side-effects of medication and increased patient-reported pain, but not with changes in patient-reported satisfaction. Opioid-free discharge analgesia should be adopted routinely

Worldwide trends in underweight and obesity from 1990 to 2022: a pooled analysis of 3663 population-representative studies with 222 million children, adolescents, and adults

Background Underweight and obesity are associated with adverse health outcomes throughout the life course. We estimated the individual and combined prevalence of underweight or thinness and obesity, and their changes, from 1990 to 2022 for adults and school-aged children and adolescents in 200 countries and territories. Methods We used data from 3663 population-based studies with 222 million participants that measured height and weight in representative samples of the general population. We used a Bayesian hierarchical model to estimate trends in the prevalence of different BMI categories, separately for adults (age ≥20 years) and school-aged children and adolescents (age 5–19 years), from 1990 to 2022 for 200 countries and territories. For adults, we report the individual and combined prevalence of underweight (BMI &lt;18·5 kg/m2) and obesity (BMI ≥30 kg/m2). For school&#x2;aged children and adolescents, we report thinness (BMI &lt;2 SD below the median of the WHO growth reference) and obesity (BMI &gt;2 SD above the median). Findings From 1990 to 2022, the combined prevalence of underweight and obesity in adults decreased in 11 countries (6%) for women and 17 (9%) for men with a posterior probability of at least 0·80 that the observed changes were true decreases. The combined prevalence increased in 162 countries (81%) for women and 140 countries (70%) for men with a posterior probability of at least 0·80. In 2022, the combined prevalence of underweight and obesity was highest in island nations in the Caribbean and Polynesia and Micronesia, and countries in the Middle East and north Africa. Obesity prevalence was higher than underweight with posterior probability of at least 0·80 in 177 countries (89%) for women and 145 (73%) for men in 2022, whereas the converse was true in 16 countries (8%) for women, and 39 (20%) for men. From 1990 to 2022, the combined prevalence of thinness and obesity decreased among girls in five countries (3%) and among boys in 15 countries (8%) with a posterior probability of at least 0·80, and increased among girls in 140 countries (70%) and boys in 137 countries (69%) with a posterior probability of at least 0·80. The countries with highest combined prevalence of thinness and obesity in school-aged children and adolescents in 2022 were in Polynesia and Micronesia and the Caribbean for both sexes, and Chile and Qatar for boys. Combined prevalence was also high in some countries in south Asia, such as India and Pakistan, where thinness remained prevalent despite having declined. In 2022, obesity in school-aged children and adolescents was more prevalent than thinness with a posterior probability of at least 0·80 among girls in 133 countries (67%) and boys in 125 countries (63%), whereas the converse was true in 35 countries (18%) and 42 countries (21%), respectively. In almost all countries for both adults and school-aged children and adolescents, the increases in double burden were driven by increases in obesity, and decreases in double burden by declining underweight or thinness. Interpretation The combined burden of underweight and obesity has increased in most countries, driven by an increase in obesity, while underweight and thinness remain prevalent in south Asia and parts of Africa. A healthy nutrition transition that enhances access to nutritious foods is needed to address the remaining burden of underweight while curbing and reversing the increase in obesit

Mujeres del valle de Toluca en pie de lucha: Negras, españolas e indígenas en los siglos XVII- XVIII

Mujeres del valle de Toluca en pie de lucha: negras, españolas e indígenas en los siglos XVII - XVIII versa en torno a la dinámica de un grupo de mujeres que no se encuentran en ningún libro de texto, que no aparecen en las imágenes de los próceres de la Independencia de México, mujeres que nadie sabe cómo eran porque nadie las pintó, nadie escribió sobre ellas, se trata de mujeres que vivieron hace más de doscientos años. Los archivos nos muestran una serie de ejemplos de mujeres españolas que fueron parte importante para la economía del Valle de Toluca, de los siglos XVII y XVIII, pero también la presencia de la mujer indígena, quien a pesar de su poca presencia documental, podemos hablar de ella y su devenir en la vida cotidiana de la Toluca colonial. Asimismo, se encuentran las negras, aquellas mujeres que las emplearon en el aseo de la casa, en la cocina, para amamantar y cuidar a los hijos de los amos, casi a todas las encontraremos en calidad de esclavas, sin embargo tuvieron la posibilidad de comprar la libertad de ellas o de sus hijos; fueron mujeres que también tuvieron iniciativa y que si bien no ocuparon cargos políticos, cuando pudieron ejercieron su derecho. Fueron mujeres del valle de Toluca quienes realizaron transacciones comerciales, dieron poder a sus maridos y a sus hijos; mujeres emprendedoras, conocedoras de las leyes, de los movimientos mercantiles, mujeres que no vivieron sus días a la sombra de un varón, que salieron a la luz pública a exigir sus derechos, y a realizar los movimientos económicos que requería su momento

El arrendamiento del diezmo y la importancia social de los hacendados arrendatarios en el valle de Toluca, según los protocolos de la Notaría No. 1 de Toluca. 1650-1700

El establecimiento de la Nueva España, dio lugar al surgimiento de una economía, que se desarrolló de manera independiente a la Corona española. En general se trató de hacer del virreinato un modelo parecido al de la Península Ibérica, sin embargo, diversos factores impidieron la aplicación de una calca perfecta, y por el contrario, dieron lugar a nuevas actividades económicas adecuadas al mundo novohispano. Una de estas fue el arrendamiento del diezmo, al que la iglesia católica tuvo que recurrir el período virreinal. A su vez, ésta estuvo estrechamente relacionada a la actividad agrícola, que dio origen a la hacienda novohispana. Hablar de diezmos y agricultura, implica hablar de estos dos actores económicos fundamentales para el entendimiento de la estructura novohispana, muestra de ello es que para la segunda mitad del siglo XVII, la institución eclesiástica y la estructura v hacendaria se encontraban plenamente consolidadas, ostentando poder e influencia económica y social. En este artículo se presenta un balance historiográfico sobre las haciendas en el valle de Toluca y la dinámica del arrendamiento del diezmo, que busca establecer los primeros derroteros para una investigación que explique la estrecha relación entre la iglesia y los hacendados novohispanos a través de dicha actividad