Mosher-Jordan dining room, Fall 1930 [Malcolmson & Higginbotham & Trout Architects, Detroit]

Malcolmson & Higginbotham with Alexander L. Trout ('05, '10e), architects. Mosher-Jordan Halls, the first large women's dormitory at the University of Michigan, was completed in the summer of 1930. The residence consists of two separate halls with a shared kitchen. The building was named in honor of the first two deans of women, Eliza M. Mosher and Myra B. Jordan. The halls were renovated and a new dining center was added in 2008 by the architectural firm Goody Clancy & Associates

Mosher Jordan dorm exterior, 1930

Malcolmson & Higginbotham with Alexander L. Trout ('05, '10e), architects. Mosher-Jordan Halls, the first large women's dormitory at the University of Michigan, was completed in the summer of 1930. The residence consists of two separate halls with a shared kitchen. The building was named in honor of the first two deans of women, Eliza M. Mosher and Myra B. Jordan. The halls were renovated and a new dining center was added in 2008 by the architectural firm Goody Clancy & Associates

Mosher-Jordan lounge, Fall 1930 [A.F. Crooks, Commercial Photographer, Flint; Malcolmson & Higginbotham & Trout Architects, Detroit]

Malcolmson & Higginbotham with Alexander L. Trout ('05, '10e), architects. Mosher-Jordan Halls, the first large women's dormitory at the University of Michigan, was completed in the summer of 1930. The residence consists of two separate halls with a shared kitchen. The building was named in honor of the first two deans of women, Eliza M. Mosher and Myra B. Jordan. The halls were renovated and a new dining center was added in 2008 by the architectural firm Goody Clancy & Associates

Prolactin inhibits cell loss and decreases matrix metalloproteinase expression in the involuting mammary gland but fails to prevent cell loss in the mammary glands of mice expressing iGFBP-5 as a mammary transgene

Insulin-like growth factor-binding protein 5 (IGFBP-5) mediates involution of the mammary gland. The decrease in DNA content and mammary gland weight which accompanies involution was inhibited by prolactin (PRL) in wild-type but not transgenic mice expressing IGFBP-5. Phospho-STAT5 protein levels were significantly lower in IGFBP-5 transgenic mice during lactation suggesting that IGFBP-5 antagonises PRL signalling in the mammary epithelium. In contrast, phospho-STAT3 levels increased during involution to a similar extent in both wild-type and transgenic mice and were unaffected by PRL. PRL inhibited gene expression of matrix metalloproteinases (MMPs) 3 and 12 but not tissue plasminogen activator or plasmin in wild-type and transgenic animals. The effects of PRL on MMPs appear to be indirect since PRL failed to inhibit MMP-3, -7 or -12 expression in HC-11 cells or in a co-transfection including an activated PRL receptor, STAT5 and a MMP-3-luciferase reporter gene. PRL is a potent inhibitor, both of cell death, an effect which is suppressed by IGFBP-5, and of MMP expression, which is independent of the actions of IGFBP-5