Limitations of conventional drinking water technologies in pollutant removal

This chapter gives an overview of the more traditional drinking water treatment from ground and surface waters. Water is treated to meet the objectives of drinking water quality and standards. Water treatment and water quality are therefore closely connected. The objectives for water treatment are to prevent acute diseases by exposure to pathogens, to prevent long-term adverse health effects by exposure to chemicals and micropollutants, and finally to create a drinking water that is palatable and is conditioned in such a way that transport from the treatment works to the customer will not lead to quality deterioration. Traditional treatment technologies as described in this chapter are mainly designed to remove macro parameters such as suspended solids, natural organic matter, dissolved iron and manganese, etc. The technologies have however only limited performance for removal of micropollutants. Advancing analytical technologies and increased and changing use of compounds however show strong evidence of new and emerging threats to drinking water quality. Therefore, more advanced treatment technologies are required.</p

An in-vitro approach for water quality determination: activation of NF-κB as marker for cancer-related stress responses induced by anthropogenic pollutants of drinking water

Epidemiological studies show that there is a link between urban water pollution and increase in human morbidity and mortality. With the increase in number of new substances arising from the chemical, pharmaceutical, and agricultural industries, there is an urgent need to develop biological test systems for fast evaluation of potential risks to humans and the environmental ecosystems. Here, a combined cellular reporter assay based on the cellular survival and the stress-induced activation of the survival-promoting factor nuclear factor κB (NF-κB) and its use for the detection of cytotoxicity and cancer-related stress responses is presented. A total of 14 chemicals that may be found in trace-amounts in ground water levels are applied and tested with the presented assay. The project is embedded within the joint research project TOX-BOX which aims to develop a harmonized testing strategy for risk management of anthropogenic trace substances in potable water. The assay identified carbendazim as a NF-κB-activating agent in mammalian cells