545 research outputs found

    Reliquias de la Iglesia de León

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    Copia digital. Valladolid : Junta de Castilla y León. Consejería de Cultura y Turismo, 2009-201

    Sermon panegyrico que en la solemne fiesta ... de San Martin de la Ciudad de Salamanca predicó ... Miguel Geronymo de Ucar, de la Compañía de Jesus ...

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    Fecha de la licencia: 1716Sign.: [calderón]4, A-C4, D2Apostillas marginalesPort. orladaCopia digital. Valladolid : Junta de Castilla y León. Consejería de Cultura y Turismo, 201

    Mystica ciudad de Dios, milagro de su omnipotencia y abismo de la gracia : historia divina, y vida de la Virgen Madre de Dios ...

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    Sign.: [], a8, b10, c-z6, 2a-2f6, 2g4, A-Z6, 2A-2M6, 2N8, 2O-2Z6, 3A-3F6, 3G4.Port. con orla tip.Front. calc.: "P. Villafranca sculptor Regius sculpsit Matriti 1668"Grab. calc.: "Marcus ab Orozco presbiter sculpsit" que representa la efigie de María Jesús de Ágreda y va situada entre n6 y o.Prologo galeato ; Relacion de la vida de la venerable Madre Sor Maria de Iesus... ; Notas a esta primera parte de la historia de la vida de la madre de Dios escrita por... Sor Maria de Iesus... / hizolas... Fr. Ioseph Ximenez Samaniego ... de la Regular Obseruancia de N.S.P. San Francisco.

    Afrodita y Anquises. Español

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    La h. de lám. representa a Afrodita y Anquises de F. Boucher.Contiene además: El pequeño poema Afrodita y Anquises de un anónimo poeta de la Escuela Homéric

    Cerebellar astrocytes co-express several ADP receptors. Presence of functional P2Y13-like receptors

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    Astrocytes exhibit a form of excitability based on variations of intracellular Ca2+ concentration in response to various stimuli, including ADP, ATP, UTP and dinucleotides. Here, we investigate the presence of the recently cloned ADP-sensitive receptors, P2Y12 and P2Y13 subtypes, which are negatively coupled to adenylate cyclase, in cerebellar astrocytes. We checked the effect of specific agonists, 2-methylthioadenosine diphosphate (2MeSADP) and ADP, on adenylate cyclase stimulation induced by isoproterenol. Both agonists significantly reduced the cAMP accumulation induced by isoproterenol. The inhibitory effect was concentration-dependent with IC50 values of 46 ± 13 and 23 ± 14 nM for 2MeSADP and ADP, respectively. The experiments were carried out in the presence of MRS-2179, a specific antagonist of P2Y1 receptor, to avoid any contribution of this receptor. Using fura-2 microfluorimetry we also proved that astrocytes responded to 2MeSADP stimulations with calcium responses in the absence and also in the presence of MRS-2179. Both effects, inhibition of adenylate cyclase and intracellular calcium mobilization, were not modified by 2MeSAMP, an antagonist of P2Y12 receptor, suggesting that were mediated by P2Y13-like receptors
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