Is the Focal Muscle Vibration an Effective Motor Conditioning Intervention? A Systematic Review

Mechanical vibration, applied to single or few muscles, can be a selective stimulus for muscle spindles, able to modify neuromuscular management, inducing short and long-term effects, are now mainly employed in clinic studies. Several studies reported as treatments with focal vibratory (FVT) can influence neuromuscular parameters also in healthy people. However, the application modalities and the consequent effects are remarkably fragmented. This paper aims to review these studies and to characterize the FVT effectiveness on long-term conditional capacities in relation to FVT characteristics. A systematic search of studies published from 1985 to 2020 in English on healthcare databases was performed. Articles had to meet the following criteria: (1) treatment based on a locally applied vibration on muscle belly or tendon; (2) healthy adults involved; (3) outcomes time analysis enduring for more than 24 h. Twelve studies were found, all of them presented an excellent quality score of 6575%. All selected papers reported positive changes, comparable with traditional long-lasting training effects. Muscle force and power were the most investigated parameters. The after-effects persisted for up to several months. Among the different FV administration modalities, the most effective seems to show a stimulus frequency of 48100 Hz, repeated more times within three-five days on a voluntary contracted muscle

Motor performance changes induced by muscle vibration

The possibility that mechanical stimulation of selected muscles can act directly on the nervous system inducing persistent changes of motor performances was explored. On the basis of literature, stimulating parameters were chosen to stimulate the central nervous system and to avoid muscle fibre injuries. A sinusoidal mechanical vibration was applied, for three consecutive days, on the quadriceps muscle in seven subjects that performed a muscular contraction (VC). The same stimulation paradigm was applied on seven subjects in relaxed muscle condition (VR) and seven subjects were not treated at all (NV). Two sessions (PRE and POST) of isometric and isotonic tests were performed separated for 21 days, in all studied groups 7 days before and 15 days after stimulation, whilst an isokinetic test was performed on VC only. In the isometric test, the time of force development showed a significant decrease only in VC (POST vs PRE mean 27.8%, P < 0.05). In the isotonic test, the subjects' had to perform a fatiguing leg extension against a load. In this condition, the fatigue resistance increased greatly in VC (mean 40.3%, P < 0.001), increased slightly in VR and there was no difference in NV. In Isokinetic test, at several angular velocities, significantly less time was required to reach the force peak (mean 20.2% P < 0.05). The findings could be ascribed to plastic changes in proprioceptive processing, leading to an improvement in knee joint control. Such action delineates a new tool in sports training and in motor rehabilitation

Factors associated with the subjective health complaints among adolescents: Results from the ASSO Project

Objectives. Subjective health complaints (e.g. headache and feeling low) are common among adolescents. The objective of this study was to identify the factors associated with the subjective health of adolescents from a population-based point of view. Material and methods. A sample of 712 students was recruited within the web-based Project ASSO (Adolescents and Surveillance System for the Obesity prevention), funded by the Italian Ministry of Health and piloted in Palermo. A 0-100 quantitative score (arbitrarily named "psychosomatic malaise index") based on the frequency of occurrence of seven subjective health complaints was created and used as outcome; socio-demographic characteristics, medical items and lifestyle data were collected as potential explanatory variables. Associations were evaluated through a bivariate analysis first, and a multiple linear regression model afterwards by correcting for confounders. Results. The psychosomatic malaise index averaged 49.0 within the girls and 36.8 within the boys. After adjustment, the psychosomatic malaise index was confirmed to be significantly higher in the females, subjects with a diagnosed disease, smokers and alcohol consumers. Conclusions. Beyond the female gender, incorrect lifestyles such smoking and drinking alcohol may play an important role in the quality of life of adolescents, and thus preventive actions by the public health services should be addressed mainly to avoid such habits in young populations. The work has been performed within the Adolescents and Surveillance System for the Obesity prevention (ASSO) Project (code GR-2008-1140742, CUP I85J10000500001), a project funded by the Italian Ministry of Health

Acute respiratory virus emergency department admissions in a tertiary care hospital in Central Italy and the relative impact on bed occupancy, January 2017-May 2022

Acute Respiratory Infections (ARIs) have a relevant impact on public health in terms of prevalence and costs associated with the diseases. This concern highlighted the need to adopt accurate surveillance systems to respond to new emergencies and meet the demand for access to care. The objective of our work is to set up, at the Azienda Ospedaliero-Universitaria Pisana (AOUP), an automated syndromic surveillance for ARI

Properties of the permeability transition of pea stem mitochondria

In striking analogy with Saccharomyces cerevisiae, etiolated pea stem mitochondria did not show appreciable Ca2+ uptake. Only treatment with the ionophore ETH129 (which allows electrophoretic Ca2+ equilibration) caused Ca2+ uptake followed by increased inner membrane permeability, membrane depolarization and Ca2+ release. Like the permeability transition (PT) of mammals, yeast and Drosophila, the PT of pea stem mitochondria was stimulated by diamide and phenylarsine oxide and inhibited by MgADP and Mg-ATP, suggesting a common underlying mechanism; yet, the plant PT also displayed distinctive features: (i) as in mammals it was desensitized by cyclosporin A, which does not affect the PT of yeast and Drosophila; (ii) similarly to S. cerevisiae and Drosophila it was inhibited by Pi, which stimulates the PT of mammals; (iii) like in mammals and Drosophila it was sensitized by benzodiazepine 423, which is ineffective in S. cerevisiae; (iv) like what observed in Drosophila it did not mediate swelling and cytochrome c release, which is instead seen in mammals and S. cerevisiae. We find that cyclophilin D, the mitochondrial receptor for cyclosporin A, is present in pea stem mitochondria. These results indicate that the plant PT has unique features and suggest that, as in Drosophila, it may provide pea stem mitochondria with a Ca2+ release channel

Adiabatic plasma lens experiments at SPARC

Abstract Passive plasma lenses in the underdense regime have been shown to give extremely strong linear focusing, with strength proportional to the local plasma ion density. This technique has been proposed as the basis of a scheme for future linear colliders that mitigates the Oide effect through adiabatic focusing. In this scenario the plasma density in the lens is ramped slowly on the scale of betatron motion, to funnel the beam to its final focus while forgiving chromatic aberrations. We present to the physics design of an adiabatic plasma lens experiment to be performed at SPARC Lab. We illustrate the self-consistent plasma response and associated beam optics for symmetric beams in plasma, simulated by QuickPIC using exponentially rising density profiles. We discuss experimental plans including plasma source development and betatron-radiation-based beam diagnostics

A novel GRN mutation in an Italian patient with non-fluent variant of primary progressive aphasia at onset: a longitudinal case report

ObjectivesWe report the clinical presentation and evolution of a case with a novel Progranulin gene (GRN) mutation and non-fluent language disturbances at onset.Materials and methodsA 60 year-old, white patient was followed due to a history of language disturbances. Eighteen months after onset, the patient underwent FDG positron emission tomography (PET), and at month 24 was hospitalized to perform neuropsychological evaluation, brain 3 T MRI, lumbar puncture for cerebrospinal fluid (CSF) analysis, and genotyping. At month 31, the patient repeated the neuropsychological evaluation and brain MRI.ResultsAt onset the patient complained prominent language production difficulties, such as effortful speech and anomia. At month 18, FDG-PET showed left fronto-temporal and striatal hypometabolism. At month 24, the neuropsychological evaluation reported prevalent speech and comprehension deficits. Brain MRI reported left fronto-opercular and striatal atrophy, and left frontal periventricular white matter hyperintensities (WMHs). Increased CSF total tau level was observed. Genotyping revealed a new GRN c.1018delC (p.H340TfsX21) mutation. The patient received a diagnosis of non-fluent variant of primary progressive aphasia (nfvPPA). At month 31, language deficits worsened, together with attention and executive functions. The patient presented also with behavioral disturbances, and a progressive atrophy in the left frontal-opercular and temporo-mesial region.Discussion and conclusionThe new GRN p.H340TfsX21 mutation resulted in a case of nfvPPA characterized by fronto-temporal and striatal alterations, typical frontal asymmetric WMHs, and a fast progression toward a widespread cognitive and behavioral impairment, which reflects a frontotemporal lobar degeneration. Our findings extend the current knowledge of the phenotypic heterogeneity among GRN mutation carriers

First Use of Model Predictive Control in Outpatient Wearable Artificial Pancreas

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