23 research outputs found
Optical control of L-Type Ca2+ channels using a diltiazem photoswitch
Get PDFL-type Ca2+ channels (LTCCs) play a crucial role in excitation-contraction coupling and release of hormones from secretory cells. They are targets of antihypertensive and antiarrhythmic drugs such as diltiazem. Here, we present a photoswitchable diltiazem, FHU-779, which can be used to reversibly block endogenous LTCCs by light. FHU-779 is as potent as diltiazem and can be used to place pancreatic β-cell function and cardiac activity under optical control
The health status of elderly persons in the last year of life: a comparison of deaths by suicide, injury, and natural causes.
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La place de l'arthroplastie totale de hanche d'emblée dans le traitement de fractures déplacées du col du fémur
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Impact of Including Peritumoral Edema in Radiotherapy Target Volume on Patterns of Failure in Glioblastoma following Temozolomide-based Chemoradiotherapy
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