8 research outputs found
Cyclic Nucleotide Phosphodiesterases and Compartmentation in Normal and Diseased Heart
- Author
- A Abi-Gerges
- A Das
- A Ghigo
- A Terrin
- A Zoccarato
- AB Burgin
- Anna Zoccarato
- B Ding
- B Sun
- BJ Bacskai
- C Sette
- C Terrenoire
- C Yan
- CE Molina
- CH Chen
- CL Miller
- CV Degen
- D Diviani
- D Fox 3rd
- D Mika
- D Mika
- DH Maurice
- DI Lee
- E Giannetta
- E Takimoto
- E Takimoto
- EJ Tsai
- EW Sutherland
- F Ahmad
- F Lezoualc’h
- F Rochais
- F Rochais
- F Vandeput
- FD Smith
- FR Heinzel
- G Di Benedetto
- G Ruiz-Hurtado
- GD Lewis
- GS Baillie
- H Mehel
- HC Hartzell
- I Verde
- ILO Buxton
- J Jurevicius
- J Layland
- J Leroy
- J Leroy
- J Wechsler
- JD Corbin
- JJ Saucerman
- JJ Saucerman
- JS Hayes
- JU Sprenger
- K Gotz
- KL Dodge
- KL Dodge-Kafka
- KL Dodge-Kafka
- L Yang
- LR Castro
- LS Wilson
- M Berthouze-Duquesnes
- M Conti
- M Conti
- M Fukasawa
- M Guazzi
- M Mongillo
- M Mongillo
- M Movsesian
- M Movsesian
- M Oikawa
- M Packer
- M Richards
- M Wagner
- M Zaccolo
- MJ Lohse
- MM Redfield
- OE Osadchii
- P Bobin
- P Molenaar
- P Pokreisz
- P-F Méry
- R Fischmeister
- R Fischmeister
- R Lukowski
- RF Schindler
- RK Perera
- RV Iancu
- S Beca
- S Beca
- S Krishnamurthy
- S Liu
- S Sanada
- S Tosaka
- SD Rybalkin
- SE Lehnart
- SF Steinberg
- SH Francis
- SN Rampersad
- SR Agarwal
- T Bethke
- T Keravis
- TC Rich
- TJ Martins
- TP Martin
- V De Arcangelis
- VO Nikolaev
- VO Nikolaev
- VO Nikolaev
- VO Nikolaev
- VO Nikolaev
- W Mokni
- W Richter
- W Richter
- W Wong
- WE Louch
- WP Feinstein
- Y Shakur
- Y Xiang
- YW Chung
- YY Sin
- Z Haj Slimane
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2017
- Field of study
International audienceCyclic nucleotide phosphodiesterases (PDEs) degrade the second messengers cAMP and cGMP, thereby regulating multiple aspects of cardiac function. This highly diverse class of enzymes encoded by 21 genes encompasses 11 families which are not only responsible for the termination of cyclic nucleotide signalling, but are also involved in the generation of dynamic microdomains of cAMP and cGMP controlling specific cell functions in response to various neurohormonal stimuli. In myocardium, the PDE3 and PDE4 families are predominant to degrade cAMP and thereby regulate cardiac excitation-contraction coupling. PDE3 inhibitors are positive inotropes and vasodilators in human, but their use is limited to acute heart failure and intermittent claudication. PDE5 is particularly important to degrade cGMP in vascular smooth muscle, and PDE5 inhibitors are used to treat erectile dysfunction and pulmonary hypertension. However, these drugs do not seem efficient in heart failure with preserved ejection fraction. There is experimental evidence that these PDEs as well as other PDE families including PDE1, PDE2 and PDE9 may play important roles in cardiac diseases such as hypertrophy and heart failure. After a brief presentation of the cyclic nucleotide pathways in cardiac cells and the major characteristics of the PDE superfamily, this chapter will present their role in cyclic nucleotide compartmentation and the current use of PDE inhibitors in cardiac diseases together with the recent research progresses that could lead to a better exploitation of the therapeutic potential of these enzymes in the future
Green Bank Telescope: Overview and analysis of metrology systems and pointing performance
- Publication venue
- Publication date
- 01/01/2022
- Field of study
Aging of the male endocrine system
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- A Belanger
- A Binnerts
- A Comfort
- A Gray
- A Iranmanesh
- A Juul
- A Ponte Del
- A Vermeulen
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- A Vermeulen
- A Vermeulen
- AA Vandervoort
- AA Werner
- AA Werner
- AB Dollins
- AJ Morales
- B Lunenfeld
- BA Warner
- BL Riggs
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- C Foresta
- CA Conover
- CE Yu
- CJ Bagatell
- CJ Rosen
- CR Parker
- D Harman
- D Rudman
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- D Simon
- DE Meier
- DH Marshall
- DR Clemmons
- DR Taaffe
- DT Villareal
- E Cauter Van
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- E Corpas
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- E Ghigo
- E Knobil
- E Seeman
- EC Uberti
- EP Guazzo
- ES Orwoll
- F Labrie
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- F Salomon
- F Waldhauser
- FD Henker
- FE Kaiser
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- G Brabant
- G Reibnegger
- GA Ponting
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- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/1999
- Field of study
Water-Limiting Conditions Alter the Structure and Biofilm-Forming Ability of Bacterial Multispecies Communities in the Alfalfa Rhizosphere
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- A Appuhn
- A Hartmann
- A Henry
- A Houlden
- A Sessitsch
- A Sharma
- A Ulrich
- A Willems
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- Ayelén Abod
- B Agaras
- B Lugtenberg
- BB Christensen
- C Dimkpa
- C Mering
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- CR Jackson
- DA Wardle
- DS An
- E Dell’Amico
- EB Roberson
- EM Vanderlinde
- Eshel Ben-Jacob
- F Nievas
- F Nievas
- F Pini
- F Zhang
- FD Andreote
- FG Sorroche
- FG Sorroche
- Fiorela Nievas
- G Berg
- G Catroux
- G Welbaum
- GA O'Toole
- GL Mark
- GR Campbell
- H Lünsdorf
- HC Flemming
- HH Zahran
- HP Bais
- HP Cheng
- I Bhattacharya
- IW Sutherland
- J Dunbar
- J Gans
- J Kuklinsky-Sobral
- J Lloret
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- J Raaijmakers
- JA Downie
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- JEM Stach
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- JW Costerton
- JY Shi
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- K Smalla
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- LL Han
- LV Rinaudi
- M Albareda
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- Publication venue
- 'Public Library of Science (PLoS)'
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- Publication date
- 01/01/2007
- Field of study
Biofilm Formation by Environmental Bacteria
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- 'Springer Science and Business Media LLC'
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- I Andriesse
- I Iben
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- IS Glass
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- Struve 0
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- VP Arkhipova
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- W Becker
- W Dziembowski
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- W Götz
- W Götz
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- W Kundt
- W Liller
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- Y Yamashita
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- Z Kopal
- Z Kopal
- Z Kopal
- Z Kvíz
- Z Kvíz
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/1984
- Field of study
Horizontal Gene Transfers with or without Cell Fusions in All Categories of the Living Matter
- Author
- A Ahantarig
- A Bandypadhaya
- A Bertucci
- A Budd
- A Budd
- A Buzdin
- A Davoodi-Semiromi
- A Ene
- A Goulet
- A Horii
- A Huq
- A Janke
- A Kandulski
- A Karboul
- A Kawai
- A la Sala
- A Matsui
- A Monier
- A Monier
- A Moustafa
- A Moustafa
- A Moustafa
- A Mukhopadhyay
- A Ménard
- A Ouakaa-Kchaou
- A Paauw
- A Rokosz
- A Roulin
- A Roulin
- A Roy
- A Sarkar
- A Shen
- A Shkoda
- A Stathis
- A Stern
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- A Sánchez-Paz
- A Tinari
- A Vardi
- A Vincent
- A Wada
- A Wakabayashi
- A Zalatnai
- A-C Lindås
- AA Ridgeway
- AB Vaidya
- AC Brown
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- AN Fontes
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- AOP Clavijo
- AP Oxley
- AR Omar
- AS Mustafa
- AV Markov
- AY Mulkidjanian
- B Austin
- B Bohle
- B Hochhut
- B Kelsall
- B Norrild
- B Pollara
- B Shiotani
- B Wang
- B Witte
- BA Stacy
- BC Bonning
- BH Abuaita
- BJ Foth
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- BJ Thomson
- BJ Thomson
- BK Diggles
- BR Herrin
- Buzdin
- C Abergel
- C Abraham
- C Arbiol
- C Bartolomé
- C Belair
- C Bernarde
- C Billich
- C Brander
- C Brochier-Armanet
- C Chapus
- C Feschotte
- C Miskey
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- C Moliner
- C Morris
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- Cholera vaccines: WHO position paper
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- E Arbuckle
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- F Balkwill
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- F Zhang
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- G del Solar
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- H Suzuki
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- HE Gendelman
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- I Damjanova
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- I Grabundzija
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- I Parwati
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- I Yang
- IA Ivanova
- IG Sava
- IM Viklund
- International Aphid Genomic Consortium
- IS Diallo
- J Becq
- J Burnside
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- J Hacker
- J Holton
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- J Jang
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- KA Bratke
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- KR Cho
- KS Kassahn
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- L Alibardi
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