DETECTION OF TENASCIN-C IN SURGICALLY EXCISED CHOROIDAL NEOVASCULAR MEMBRANES.

Increase of tenascin-C (TN-C) expression has been found in pathologic tissues in which angiogenesis occurs. The aim of this study was to investigate TN-C expression in human choroidal neovascularization (CNV)

New insight on choroidal vasculature: multimodal morphofunctional approach

maging the choroid in vivo using standard modalities is difficult because of light scattering within overlying tissue, particularly the retinal pigment epithelium (RPE). Although the choriocapillaris is composed of relatively large-diameter capillaries, they are interconnected in a dense arrangement. The flow in the choriocapillaris is fast and because of the prominent fluorescein leakage vascular structure is obscured. Indocyanine green dye shows less leakage than fluorescein, but it still leaks from the choriocapillaris and stains Bruch’s membrane and the choroidal stroma. Optical coherence tomography angiography has high axial resolution, but the lateral resolution is insufficient to visualize the choriocapillaris clearly in the posterior pole. Nevertheless, it can detect choriocapillaris blood flow, producing contrast between the RPE and choriocapillaris. However, because of signal loss, fringe wash-out, and thresholding used in signal processing, the vessels in Sattler’s layer and certainly in Haller’s layer appear dark in normal eyes. Purpose of the lecture is to evaluate various choroidal multimodal imaging findings and to allocate them in the context of different macular diseases

Silent occult choroidal vascular abnormalities.

To describe clinically occult choroidal vascular abnormalities that can be revealed by indocyanine green (ICG) angiography

High-dose antioxidants for central serous chorioretinopathy; The randomized placebo-controlled study

<p>Abstract</p> <p>Background</p> <p>To determine the efficacy of high-dose antioxidants in the acute stage of central serous chorioretinopathy (CSC).</p> <p>Methods</p> <p>This was a randomized placebo-controlled study. The patients with acute CSC (onset within 6 weeks) were randomized to receive either high-dose antioxidant tablets (study group A) or placebo tablets (control group B) for 3 months or until the complete resolution of subretinal fluid. After 3 months, additional treatment with laser or photodynamic therapy (PDT) was considered if any fluorescein leakage persisted. The outcomes measured were the changes in visual acuity (VA) and central macular thickness (CMT), the number of patients with subretinal fluid at each follow-up time, the number of patients with fluorescein leakage at the end of the 3^rd month and patients who received additional treatments.</p> <p>Results</p> <p>Fifty-one of 58 patients (88%) completed the follow-up criteria. The baseline demographic data were comparable in both groups. At the end of the 3^rd month, the VA and CMT showed no statistical difference between the groups but the patients in group A has less fluorescein leakage and additional treatments than in group B (p = 0.027 and 0.03).</p> <p>Conclusion</p> <p>The high-dose antioxidants for acute CSC did not show any benefits in VA and CMT. However, the drugs might decrease the chance for fluorescein leakage and additional treatments at the end of the 3^rd month.</p

Multiple bilateral choroidal metastatic tumors from a small-cell neuroendocrine carcinoma of unknown primary site.

To report one case of multiple and bilateral choroidal tumors from a poorly differentiated small cell neuroendocrine carcinoma of unknown primary