LOT STREAMING IN A 2-STAGE FLOW-SHOP WITH SET-UP, PROCESSING AND REMOVAL TIMES SEPARATED

This paper considers the job (lot) scheduling problem for two-stage flow shops in which the movement of transfer batches (sublots) from the first stage to the next are allowed. Set-up, processing and removal times are considered as separable and independent of the order in which jobs are processed at any of two stages. An optimal transfer batch sizing and scheduling algorithm which has an objective of minimizing the maximum flow time (makespan) is developed and demonstrated by a numerical example

UNIT SIZED TRANSFER BATCH SCHEDULING WITH SETUP TIMES

Transfer batch scheduling permits the movement of some portion of a job or lot at downstream stages before the entire job is completed at the current stage. This paper considers the two stage flow shop problem of minimizing the total completion time, in which all transfer batches are of unit size for each job. An optimal solution procedure is developed for unit sized transfer batch scheduling with setup times which are independent of the sequence and are separated from the processing times at both stages

Synthesis and Combinational Antibacterial Study of 5 -Modified Neomycin

A library of 5″-modified neomycin derivatives were synthesized for an antibacterial structure–activity optimization strategy. Two leads exhibited prominent activity against both methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci (VRE). Antibacterial activities were measured when combined with other clinically used antibiotics. Significant synergistic activities were observed, which may lead to the development of novel therapeutic practices in the battle against infectious bacteria