Study of methylation reactions of 2-phenylquinazoline-4-tion with “soft” and “hard” methylation agents and determination of its biological activity

Alkylation reactions of 2-phenylquinazoline-4-thion with methylation agents “soft” (methyl iodide) and “hard” (dimethyl sulfate, methyltozylate) were studied. It was found that the reaction proceeds with the formation of alkyl products at the N3 - and S4 - reaction centers, depending on the methylation agent, solvent and temperature. This indicated the ambivalent nature of the 2-phenylquinazoline-4-tion anion. Prolongation of the reaction time leaded to the formation of a second isomeric product (VII). A slight increase in phenyl N3-product (VII) yield was noted when dimethyl sulfate and methylfolate were used as methylation agents. In non-polar proton-free solvent DMF and dipolar proton-free solvent acetonitrile, only N-methyl product (VII) was formed because of the reaction. An increase in the polarity of the solvent and the “hardness” of the methylation agent leads to an increase in the yield of N3 products

The biochemical effects of the coordination compound of cobalt-ii nitrate quinazolin-4-one with 3-indolyl acetic acid in the “amber” plants grades phaseolus aureus

The biochemical effects of the coordination compound of cobalt-II nitrate quinazolin-4-one with 3-indolyl acetic acid in the “amber” plants grades Phaseolus aureus have been studied. Cobalt is an important trace element for plants and an important biogenic element in the soil, mainly in the form of the Co2+ cation, which participates in redox reactions in plant organisms for the implementation of various mineral and organic compounds. Cobalt compounds are mainly soluble in mineral acids, so we want to show that the coordination compound containing this trace element, formed by the nitrate salt with quinazolin-4-one, serves as a source of plant nutrition

To examine the processes of biochemical action of cobalate ii-nitrate and quinazolin-4-on on the “Morus alba” variety of Moraceae plant of the coordination compound formed by 3-indole fatty acid

In the article, the synthesis of quinazolin-4-on, the reaction of its interaction with indole fatty acid and the synthesis of the coordination compound formed by cobalt (II)-nitrate, the biochemical action of the mulberry plant on the “morus alba” variety of the moraceae plant with the participation of various solvents, the development of root system, photosynthesis in the leaves, and methods

Kobalt (II) - synthesis of the coordination compound formed by quinazolin-4-on and indole fatty acids of nitrate dihydrate and study of the processes of influence on the varieties of cotton “Buxara-102”, “Namangan-77”, “Sultan”, “Unkurgan-1”, “C-6524”

Below we would like to present for the first time the coordination compound formed by quinazolin-4-on and indole fatty acids of cobalt (II)-nitrate dihydrate, the processes affecting the root-firing system of the varieties “Buxara-102”, “Namangan-77”, “Sultan”, “Unkurgan-1”, “C-6524”. Prior to us, synthesis processes and biological effects were studied by individual individuals, and coordination compounds with these substances were not synthesized